受体

Chronicity maybe result from many factors with complex mechanism.HCV may evade the host immune surveillance due to the hypermutation of HCV gene; HCV has the nature of pantropic,the tissues outside liver can provide virus for repeatedly infection of liver; The HCV receptors,such as CD81,LDL receptor,scavenger receptor B type I,L-SIGN,DC-SIGN and so on,may influence organism humoral immunity and the cellular immunity function in different degrees; HCV infection also may cause the reduction of quantity of organism immune cell or functional defect,low response of humoral immune response,tolerance of cellular immunity,then,the host finally transforms into chronic infection condition.

其慢性化的机制非常复杂，是由多个因素造成的，HCV因其基因高变性可以逃避宿主的免疫监视；HCV具有泛嗜性，肝外组织又可为肝组织的反复感染提供病毒来源；CD81、LDL受体、清道夫受体B类Ⅰ型及L-SIGN、DC-SIGN等HCV受体又可不同程度地影响机体的体液免疫和细胞免疫功能；HCV感染亦可直接导致机体免疫细胞数量减少或功能缺陷，体液免疫应答水平低下、细胞免疫耐受，宿主最终转变为慢性感染状态。

Other 3-(2-aminoethyl)substituted phthalide\'s derivatives were synthesized by Reductive Alkylation of 3-aminoethylphthalide, which was obtained by hydrogenation of 3-acetonitrile phthalide.

比扣扣灵(Bicuculline，BIC)是GABAa受体的经典竞争性拮抗剂，它与GABA识别位点高亲和力结合，选择性阻断GABAa受体，故长期以来一直把它作为识别GABAa受体的工具药。

Recent studies have revealed that GRKs and arrestins also play important roles in endocytosis of GPCRs related to receptor resensitization.

受体为了对激动剂浓度的快速变化作出反应，失活的受体还必须很快复活才能为再次刺激作储备，这就涉及受体的内陷和复敏，近来发现这些过程也与GRKs和arrestins有关。

Their regulation is implemented through interaction between two types of nuclear receptors: retinoic acid receptor（RARand retinoid X receptor.

其调节作用是通过两种核受体的相互作用实现的：视黄酸受体和类视黄醇X受体。

These results suggest that evodiamine has greater anti-proliferative effects than rutaecarpine and possesses a potential for suppressing the proliferation of breast cancer cells via a mechanism involving attenuation of ERαand ERβ, interference of ERα phosphorylation and activation of apoptotic modulators.

故吴茱萸碱透过抑制α雌激素受体和β雌激素受体的表现、干扰α雌激素受体的磷酸化以及活化细胞凋亡调控因子来抑制乳癌细胞的增生。

Measure normal early pregnancy choria tissue and JAR cell by RT-PCR, LH/hCG receptor mRNA expression on both pregnancy choria tissue and JAR cell which is consistent with that be measured in ovarian granulosa cells, indicate that JAR cell and normal choria trophocyte presence LH/hCG receptor, hCG is one of the autocrine hormone.

二、用RT-PCR法可测到正常妊娠早孕绒毛组织、JAR细胞的LH／hCG受体mRNA表达，与正常卵巢颗粒细胞所表达的LH／hCG受体mRNA一致，提示JAR细胞与正常绒毛滋养细胞存在LH／hCG受体，hCG为其自分泌激素之一。

Clonidine (20ug/bilateral), an alpha agonist, produced similar effect as NA; while phentolamine (10ug/unilateral), an alpha antagonist, brought about an enhancement of AA, This phenomenon was observed in the acupuncture effective group, but not in the acupuncture uneffective one. However, propranolol (10ug/unilateral), a beta antagonist, had no effect on AA in these two groups.

结果表明，微量注射NA（0.5μg/单侧）能部分翻转针刺镇痛作用；α受体激动剂可乐定（20μg/双侧）也有同样作用；而α受体拮抗剂酚妥拉明（10μg/单侧）可以显著加强针刺有效组家兔的针刺镇痛作用，但对针刺无效组的痛阈无明显影响；β受体拮抗剂心得安（10μg/单侧）则对针刺有效或无效组的痛阈均无显著作用。

Furthermore, preliminary work also performed to examine whether PI3K/AKT signal transduction pathway was activated in the process of refractory leukemia development. Materials and methods An immortalized human bone marrow stromal cell line, HS-5, was introduced to establish a bi-phase culture system for the cultivation of B-lineage precursor leukemia cells. ELISA and RT-PCR were used to investigate the expression of VEGF and its receptors in the leukemia cell lines and primary childhood leukemia cells in different treated groups. Flow cytometory method and immunofluorescent staining were employed to examine the apoptosis signals both in the VP16 treated and untreated leukemia cells. Western blot was utilized to explore the PI3K/AKT activated status in the drug induced or uninduced leukemia cells and lymphocytes from healthy donors.

材料和方法使用来源于人类骨髓基质细胞的细胞株HS-5作为滋养层细胞进行急性淋巴细胞性白血病细胞的体外培养，通过细胞生物学和免疫学方法评估培养体系并鉴定出难治性白血病细胞克隆；以ELISA和RT-PCR方法检测急性白血病细胞株和患儿白血病细胞VEGF及其受体的表达，了解不同治疗阶段VEGF及其受体的表达状况，并结合临床指标进行分析，明确VEGF及其受体在白血病发生过程中的作用；流式细胞仪和免疫荧光染色法对正常健康儿童、初发白血病患儿、复发白血病患儿及缓解后患儿进行凋亡因子检测和分析，初步阐明难治性白血病抗凋亡形成的原因；蛋白印记分析检测PI3K/AKT信号传导通路在健康儿童、初发白血病和复发白血病患儿的表达，初步了解难治性白血病形成的分子生物学机制。

It has been postulated that Angiotensin Ⅱ type 2 receptor (AT2) functionally antagonizes ac 1 (AT1) receptor.

基于目前对血管紧张素Ⅱ2型受体（AT2）功能的认识，认为血管紧张素Ⅱ1型受体（AT1）和AT2受体有相互拮抗作用。

The purpose of the paper is to build a module of small molecular receptor fragments charactering normal VLDL-R binding function and study the mechanism of VLDL-R binding to ligand.

建立具有正常极低密度脂蛋白受体结合功能的小分子受体片段模型并借助此模型研究VLDL受体与配体结合的作用机制。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。