取代...

The compounds are represented by the structural Formula 1, Chemical formula should be inderted here as it appears on the abstract in paper form. a prodrug thereof, or any pharmaceutically acceptable salt, solvate, isomer or racemic mixture of the compound or said prodrug wherein R1 is heteroaryl, N-arylaminocarbonyl, N-heteroarylaminocarbonyl, benzimidazolyl or benzothiazolyl; R15 is present or not and if present is H, aryl, alkyl, arylalky or heteroarylalkyl; A is aryl, heteroaryl, cycloalkyl, cycloalkylidene, heterocycloalkylidene or heterocycloalkyl wherein said aryl, heteroaryl, cycloalkyl, cycloalkylidene, heterocycloalkylidene and heterocycloalkyl moieties may be substituted or unsubstituted; and B, L, X and R18 are defined herein.

所述化合物用结构式1表示，包括其前药或所述化合物或所述前药的任何药学上可接受的盐、溶剂合物、异构体或外消旋混合物，其中R 1 为杂芳基、N-芳基氨基羰基、N-杂芳基氨基羰基、苯并咪唑基或苯并噻唑基；R 15 存在或不存在，如果存在，则为H、芳基、烷基、芳基烷基或杂芳基烷基；A为芳基、杂芳基、环烷基、环烷叉基、杂环烷叉基或杂环烷基，其中所述芳基、杂芳基、环烷基、环烷叉基、杂环烷叉基和杂环烷基部分可被取代或未被取代；B、L、X和R 18 如说明书所定义。

A series of cholesterol-bearing O-carboxylmethyl chitosan conjugates with different degrees of substitution of the cholesterol moieties and cholesterol-bearing chitosan were synthesized by the succinyl linkages and characterized by Fourier transform infrared, Proton Nuclear Magnetic Resonance (~1H NMR) and elemental analysis. These hydrophobized chitosan derivatives were amphiphilic in nature and their self-aggregation behavior in aqueous media was evaluated by the fluorescence probe technique.

课题的主要研究内容如下：采用化学的方法合成了不同分子结构、不同取代度的系列胆甾醇基壳聚糖衍生物—胆甾醇基壳聚糖和胆甾醇基-羧甲基壳聚糖，并应用先进的分析手段电位滴定、红外光谱法(IR、核磁共振波谱法等对原料、中间产物以及产物进行了结构表征，衍生物分子中的胆甾醇基取代度(3.2％～12.5％)采用元素分析的方法进行检测。

A series of sulfanilamide group substituted derivatives were optimized on the basis of the semi-empirical quantum chemistry PM3 method.

以量子化学半经验PM3法对含磺胺基的一类有机化合物分子进行了几何构型优化，计算了分子的二阶非线性光学系数和电子转移，讨论了磺胺基在非线性光学材料设计中的特点和作用以及不同的取代基及取代位置对分子二阶非线性光学系数的影响

An economic theory of the firm must explain both when firms supplant markets and when markets supplant firms.

企业的经济理论必须解释两个问题：企业什么时候取代市场和什么时候市场取代企业。

And the effect of the synthesized compounds to T-lymphocyte transformation was investigated using methyl thiazolyl tetrazolium method.

结果显示：长链酰基取代后的化合物4a～4d和5a～5d对小鼠T-淋巴细胞增殖的抑制活性明显优于未取代的底物2和3。

The results reveal that the position, as well as the number, of sulfate substituent of S-b-CD plays an important role in the enantiomerization reaction of thioridazine.

此结果显示对掌异构物间的转换，与所使用特定的对掌选择剂有关，也意谓S-b-CD的硫酸根取代基位置与取代基数目在thioridazine的对掌异构化扮演著重要的角色。

When the office of a senator becomes vacant under section 119, the provisions of section 112, section 113, section 114 and section 118 shall apply mutatis mutandis to the election or selection of a senator, as the case may be, and the replacing senator shall remain in office for the unexpired term of office of the member he replaces.

当办公室的一位参议员悬空根据第119条的规定，第112条，第113 ，第114和第118条应比照适用于选举或选择一个参议员，视情况而定，并取代参议员应继续留任的未满任期的成员，他取代。

The results show that the alloys are composed of LaNi5 as matrix and LaNi3 as secondary phase. With the increasing Sm substitution for La, the unit cell volume of matrix of the alloys shrinks linearly and both the hydrogen storage capacity and discharge capacity decrease. When the Sm substitution is 0.1, 0.2 and 0.3, the discharge capacity decreases from 380 mA·h/g to 370(362), 355(334) and 329(295) mA·h/g, respectively. However, the rate performance and cycle stability is improved. After 100 cycles, the capacity loss decreases from 20% to 18%(17%), 16%(14%) and 13%(11%).

结果表明：该合金是由LaNi5主相和LaNi3第二相构成；随着Sm取代La量的增加，合金主相单胞体积线性收缩，合金储氢量和放电容量减小，当Sm取代量分别为0.1、 0.2、 0.3时，合金容量由380 mA·h/g分别减小到370(362)、 355(334)、 329(295) mA·h/g，但高倍率放电能力和循环稳定性得到改善， 100次循环后的容量损失率由20%分别降低到18%(17%)、 16%(14%)、 13%(11%)。

The results show that the alloys are composed of LaNi5 as matrix and LaNi3 as secondary phase. With the increasing Sm substitution for La, the unit cell volume of matrix of the alloys shrinks linearly and both the hydrogen storage capacity and discharge capacity decrease. When the Sm substitution is 0.1, 0.2 and 0.3, the discharge capacity decreases from 380 mAh/g to 370(362), 355(334) and 329(295) mAh/g, respectively. However, the rate performance and cycle stability is improved. After 100 cycles, the capacity loss decreases from 20% to 18%(17%), 16%(14%) and 13%(11%).

结果表明：该合金是由LaNi5主相和LaNi3第二相构成；随著Sm取代La量的增加，合金主相单胞体积线性收缩，合金储氢量和放电容量减小，当Sm取代量分别为0.1、0.2、0.3时，合金容量由380 mAh/g分别减小到370(362)、355(334)、329(295) mAh/g，但高倍率放电能力和循环稳定性得到改善，100次循环后的容量损失率由20%分别降低到18%(17%)、16%(14%)、13%(11%)。

As is so often pointed out, modern technology make the relationship between people become more impersonal and aloof. The early initiative handicraft has been replaced by assembly line of machinery, and the works' jobs are always unutterably boring. The bargaining between people also gives its ways to the high efficient trade in the supermarket.

正如许多人提高的，现代技术已经使得人们之间的关系更加冷漠，早期富有创意的手工劳动已经被机器所取代，而操作机器的工人的工作异常的枯燥，过去讨价还价的热闹景象也开始逐渐被超市里的冷漠的贸易所取代。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。