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The reproductive toxicity of Aroclor 1254 on the oogenesis, the fertilization and preimplantion embryonic in vivo in female mice, the spermatogenesis toxicity, the sperma fertilizing ability and the zygote developmental toxicity in vivo in male mice were studied, and the toxicity mechanism were discussed by histopathological examination of the ovary, the uterus, the testis and epididymides.

以小鼠为动物模型,研究了类二噁英多氯联苯的典型代表物质——Aroclor 1254对母鼠卵子发生、受精和附植前胚胎体内发育毒性,公鼠精子发生毒性,以及对精子受精能力和受精卵体内发育的毒性。

Conclu sion:(1)Surface densities of PCNApositive cells reached their peaks on 14th day after birth,but the number of apoptotic cells reached its peaks on 21st day p ostnatal,so the apoptotic peak was late the proliferating peak for a week,and related to the particular period in cycle of seminiferous epithelium;(2)The spe rmatogium were found move from center to the periphery of the seminiferous tubule and arrange disorder to order;(3)The spermatogonium remained replicating activ ity of DNA during the developing stage.

生精细胞凋亡的高峰要滞后其增殖峰1周左右,而且与其所处生精周期的特定阶段有关;(2)精原细胞在胚胎发育过程中向曲细精管周边迁移,其排列由无序到有序;(3)在生后各发育阶段中,精原细胞始终保持DNA复制的能力。

Moreover, reef-shoal dolomite (subordinate organisms and sparry grain dolomite microfacies) reservoir pores develop with a large-scale distribution, abundant dissolved pore types and excellent reservoir capability; evaporite platform dolomite (non-lamina dolomite mudstone microfacies) takes second place with average reservoir capability; reef limestone pores develop with lower reservoir capability, regarded as III class of reservoir at most; open-platform limestone (non-lamina dolomite mudstone microfacies)pores underdevelop with no reservoir capability.

此外,通过孔隙演化研究可以看出礁滩云岩(生物粘结云岩和亮晶颗粒云岩微相)储层孔隙规模最大,溶孔类型丰富,储集性能最好;蒸发台地云岩次之,储集性能一般;礁灰岩孔隙也有发育,储集性能较差;开阔台地灰岩孔隙不发育,几乎不具备储集能力。

BACKGROUND: Compared with adult mesenchymal stem cells, yolk sac-derived MSCs of early embryo have stronger self-renewal capacity and plasticity. Moreover, they could differentiate into angioblast and hemopoietic stem cells during embryonic development and trigger embryonic angiogenesis and hemopoietic tissue development.

背景:与成体间充质干细胞相比,来源于早期胚胎的卵黄囊间充质干细胞有更强的自我更新能力和可塑性,且在胚胎发育过程中可分化为成血管细胞和造血干细胞,启动胚胎血管发生和造血组织发育。

BACKGROUND: Embryonic stem cells develop from early blastular inner cell mass. Under proper condition, ESCs can maintain undifferentiated state in vitro, normal diploid nuclear type, and proliferative potential. In addition, ESCs possess multi-directional differentiation capacity and can differentiate into all sorts of cells of three germ layers.

背景:胚胎干细胞来源于发育早期囊胚的内细胞团,适当条件下能在体外维持未分化状态、正常二倍体核型及无限增殖能力,且具有多向分化潜能,能够发育分化成机体3个胚层的所有类型细胞。

The main content includes the metabolism and energy balance; the ontogenesis of biological rhythms; the development of nervous system and endocrinological regulating mechanisms; the factors affecting the fetal development and growth; the relationships of fetal development to the reproductive and reproductive abilities of adult animals.

主要内容包括胎儿的新陈代谢与能量平衡;生物节律的形成;胚胎期神经系统和主要内分泌器官的发生和调节机制的建立;影响胚胎发生发育的主要因素以及动物的发生发育与成年动物生产与生殖能力的关系。

Used with caution in pregnant women. 2, estrogen medication during early pregnancy can cause fetal hydrocephalus, cerebral meningocele, visceral malformations, feminization of male fetus, testicular dysplasia, low reproductive capacity, pregnant women忌用. 3, pregnant women taking high-dose folic acid may be a high concentration of zinc metabolism in pregnant women do together which led to scattered and intrauterine fetal growth retardation and low birth infants rationale. 4, a cold fever of 39 degrees sustained for more than 24 hours can cause fetal facial malformations such as lip.

孕妇慎用。2、雌激素妊娠早期用药可致胎儿脑积水,脑脊膜膨出、内脏畸形,男胎女性化,睾丸发育不良,生殖能力低下,孕妇忌用。3、孕妇服用大剂量高浓度叶酸可干拢孕妇锌代谢而导致胎错落和宫内发育迟缓和低出生体理儿。4、感冒发热达39度以上持续24小时以上可引起胎儿面部畸形如兔唇。

Data were analyzed from photographs from optical microscopy and Computer Image Analysis.Results:Gene expression level of bcl-2mRNA (numeric density and concentration of bcl-2 immunopositive neurons) in layer Ⅲ of the ipsilateral visual cortex area 17 and the laminas receiving ipsilateral geniculate input from the strabismic and deprived eyes are significantly lower than the input from the untreated eyes.

MS1和MD1组幼猫实验眼同侧视皮质17区Ⅳ层及同侧外侧膝状体Al层神经元在视觉发育敏感期内,由于长期的斜视及形觉剥夺效应以致功能低下,对Bcl-2调节的敏感性降低,以及对NTs的营养保护及上调Bcl-2 mRNA表达水平应答能力降低,在双眼竞争的神经元发育及突触连接中处于劣势,使对侧眼形成优势循环。

Following chemical activation, blastocysts rate of the treated oocytes was similar to untreated oocytes.8 Following fertilization, however, few oocytes inhibited with CHX developed into morulae/blastocysts, due to a high incidence of polyspermy.9 Cortical granule migration occurred during inhibition, but CHX inhibition impaired CG migration, significantly no oocytes inhibited by CHX completed CG migration after maturation.10 CHX inhibition had no effects onα-microtubles and microfilaments of goat oocytes.

抑制24h转为正常培养24h,不影响卵母细胞的成熟和孤雌激活能力,并且CHX抑制后再成熟的卵母细胞经孤雌激活发育到囊胚的比例与对照组卵母细胞相似。8、体外受精后,CHX抑制后再成熟卵母细胞的多精受精现象显著增加,发育到桑椹胚/囊胚的比例显著低于对照组。9、CHX抑制过程中皮质颗粒仍能发生迁移,但是CHX抑制会对皮质颗粒的迁移造成不可恢复的损伤,使再成熟的卵母细胞内皮质颗粒不能完全迁移。10、CHX抑制对山羊卵母细胞α-微管和微丝都没有影响,无论是抑制后处于生发泡期的卵母细胞,还是抑制后再成熟的卵母细胞,微管和微丝的分布都与对照卵母细胞相似。

Therefore, under the background of the society transformation accelerating and the social problem overgrowing, to inspect non-government organization' growth in our state, and evaluate its conducts as well as shortcomings objectively and furthermore explores it' development route actively is of great benefit for us.

因此,在社会转型加剧和社会问题丛生的背景下,在从国家中心主义迈向福利多元主义的路途中,检视非政府组织在我国的成长发育,客观地评估其作为与局限,积极探寻其发展思路与建议,对于我们正确理解国家能力建构和市民社会发育之间的关系、实现我国非政府组织发展的超越大有裨益。

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In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

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