发育异常

Result: The study shows that the quantities of the Purkinje Cell in the heart of anencephalus are less than those in the heart of normal foetus.

无脑儿神经系统发育异常影响其心脏内蒲肯野细胞的发育。

The C-terminal half is responsible for its binding ability as to homeodomains, HIRA-interacting protein 3(HIRIP3), and core histones. HIRA is well conserved during the long evolutionary pathway which indicates that this protein may be essential for life development.

HIRA在从酵母到人类的长期进化过程中高度保守，说明其在生命发育过程中起着重要作用。mHira基因敲除的小鼠胚胎表现出复杂的表型缺陷，原条扭曲，脊索和神经管发育异常，发育至孕中期时全部死亡。

So,detection of SRY gene may play an important role in the study of hypospadias.

2先天性尿道下裂是一种性别发育异常，尿道缺失是性腺发育不全表现。

Five fetuses were diagnosed with female pseudohermaphroditism (21-hydroxylase deficiency in 3 and urorectal septum malformation sequence in 2). Four fetuses were diagnosed with male pseudohermaphroditism (1 with steroid sulfatase deficiency, 1 with presumed camptomelic dysplasia, and 2 undetermined).

在这16个胎儿中有5个被诊断为女性假两性畸形（其中3个有21-羟化酶分泌不足，2个有尿道直肠隔畸形），4个被诊断为男性假两性畸形（其中1个有类固醇硫酸酯酶分泌不足，1个推测可能为弯肢性发育异常，另外2个原因未定），5个有染色体异常，2个有性逆转，核型为（46，XX+SRY）。

The aberrant epigenetic reprogramme is an important cause for abnormal development of nuclear transfer embryos.

表观重编程异常是核移植胚胎发育异常的重要原因。

It is concluded that alcohol has developmental toxicity and teratogenicity. The target organ affected by alcohol is brain. The effects of alcohol on the developmental differentiation of visceral yolk sac and DNA synthesis are probably related to its developmental abnormalities.

结论认为酒精具有发育毒性和致畸性，酒精作用的主要靶器官是脑，酒精对卵黄囊发育分化和DNA合成的影响可能与其发育异常有关。

Herpes simplex virus infection to the fetus through the placenta, pregnancy first 8 weeks of infection and occurrence of fetal malformations can generally mainly small head, small eyes, chorioretinitis, crystal turbidity, heart abnormalities, limb abnormalities, intrauterine growth retardation, cerebral dysgenesis, hydrocephalus, corneal cataract formation of the liver, splenomegaly, pneumonia and so on. 2, diagnosis:(1) direct examination, electron microscopy examination herpes fluid, can be found herpes virus-like particles.

单纯疱疹病毒通过胎盘传染给胎儿，妊娠头8周感染可使胎和发生畸形，一般主要为小头，小眼，脉络膜视网膜炎，晶体混浊，心脏异常，肢体发育异常，宫内生长迟缓，脑发育不全，脑积水，角膜翳形成肝，脾肿大，肺炎等。2、诊断：(1)直接检查，用电镜检查疱疹液，可发现疱疹病毒颗粒。

Results Metaphyseal chondrodysplasia is a rare osteopathy that would lead to short limb type pygmy or mutilation bone disease .

结果 干骺端软骨发育异常是较罕见的全身短管状骨干骺端软骨发育异常导致短肢型侏儒或致残性体质性骨病。

Our study displayed that HmgD overexpression mutant died as late third instar larvae and malformed pupae during the larvae-prepupa transition,suggests that overexpression of HmgD has effects rather on the third instar larvae stage than on the first and second instar larvae from the mutant could not pupate.

结果表明，HmgD广泛过量表达突变体幼虫在一龄和二龄期发育正常，而在三龄幼虫化蛹时发育异常，发育停滞在三龄幼虫末期至预蛹的阶段，即HmgD过量表达的幼虫不能正常化蛹。

Results: The risk factors for leukemic transformation and early death were bone ache, Hb＜30 g/L, dysplastic peripheral blood polymorphs, RAEB,RAEB-T of MDS subtype, blast of bone marrow and peripheral blood＞5%,with advancing myelofibrosis, ALIP,-7/7q-+8 and cytogenetic abnormalities at more than two chromosomes.

结果：剧烈骨痛、Hb＜30 g/L、外周血粒系发育异常、RAEB、RAEB-T MDS亚型、骨髓或外周血原始细胞＞5%、伴发MF和ALIP、-7/7q-，+8染色体异常或复合染色体异常为MDS预后不良因素。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。