发育异常

The top of neural tube forms basic encenphalic shape,namely endbrain, interbrain, midbrain and afterbrain. The abnormal closure of neural tube will result in neural tube detects. Encephalocoele is a common congenital malformation whose mechanism was no known. NO participates in the physiologic process of brain.

胚胎脑发育的早期阶段主要是神经板隆起、弯曲、闭合形成神经管，神经管的头部从前向后依次发育形成脑的基本组织形态，即端脑、间脑、中脑、后脑，在神经管闭合过程中出现异常就会导致NTD。

But the abnormal phenomena in autotetraploid rice were more than that in diploid rice.

同源四倍体水稻胚囊发育过程与二倍体基本一致，但在同源四倍体水稻胚囊的形成和发育过程中出现了较多的异常现象。

Their motion asymmetry supported the idea of close correlation between motion perception symmetry and binocularity.

三位双上旋肌麻痹，一位视神经重度发育不全，一位早产儿网膜症，两位合并水平及垂直斜视，一位角膜彼得氏异常和一位网膜先天缺损，他们自出生起就没有发育双眼视觉的机会，他们不对称的运动觉支持了运动觉对称性和双眼视觉之间相关性的理论。

In view of geological records preserved from different regions of the world are not identical, it's suggested that, when correlating the Ordovician-Silurian boundary, at the global boundary stratotype section, the FAD of N. persculptus be selected as the biomark, the transgression event identical to the FAD of N. persculptus as the auxiliary physical mark and the mass extinction and chemical anomaly events respectively as the auxiliary biomark and chemomark. In some regions with few graptolite, the Ordovician-Silurian boundary should be indicated by the auxiliary marks, such as the transgression event, mass extinction or chemical anomaly event, with the other fossil such as conodont nearest to other geological events as the provincial biomark for correlation. In other regions with much stratigraphic hiatus originated from the regression, the Ordovician-Silurian boundary should be marked by the regression-transgression event nearly relevant to the N. persculptus Zone.

鉴于不同地区留下的地质记录不完全相同，奥陶/志留系界线对比方法不同：在界线层型剖面上，以N.persculptus的首现为生物标志，以与之基本一致的海侵事件为辅助的物理标志，以生物集群绝灭事件和化学异常事件为辅助的生物和化学标志；在笔石极不发育的地区，则以海侵事件、生物绝灭事件或化学异常事件为辅助标志，以与其相距最近、并且具有区域对比性的其它门类化石作为界线对比的生物标志；对于由于海退事件所造成地层缺失很多的地区，则以海退/海侵事件作为划分界线的物理标志，并以相映的海侵事件的开始作为奥陶/志留系的分界。

In viewof geological records preserved from different regions of the world are not identical, its suggested that, whencorrelating the Ordovician-Silurian boundary, at the global boundary stratotype section, the FAD of N.persculptus be selected as the biomark, the transgression event identical to the FAD of N. persculptus as theauxiliary physical mark and the mass extinction and chemical anomaly events respectively as the auxiliarybiomark and chemomark. In some regions with few graptolite, the Ordovician-Silurian boundary should beindicated by the auxiliary marks, such as the transgression event, mass extinction or chemical anomaly event,with the other fossil such as conodont nearest to other geological events as the provincial biomark forcorrelation. In other regions with much stratigraphic hiatus originated from the regression, theOrdovician-Silurian boundary should he marked by the regression-transgression event nearly relevant to the N.persculptus Zone.

鉴于不同地区留下的地质记录不完全相同，奥陶／志留系界线对比方法不同：在界线层型剖面上，以N.persculptus的首现为生物标志，以与之基本一致的海侵事件为辅助的物理标志，以生物集群绝灭事件和化学异常事件为辅助的生物和化学标志；在笔石极不发育的地区，则以海侵事件、生物绝灭事件或化学异常事件为辅助标志，以与其相距最近、并且具有区域对比性的其它门类化石作为界线对比的生物标志；对于由于海退事件所造成地层缺失很多的地区，则以海退／海侵事件作为划分界线的物理标志，并以相映的海侵事件的开始作为奥陶／志留系的分界。

There are according to B-, or whether the early detection of fetal abnormalities, such as: limb development, development of hand-toe toe, with or without harelip and heart bone, internal organs can be seen, as well as whether there is hydrocephalus!

还有照B超，也可以早期发现胎儿有无异常，例如：四肢发育，手趾脚趾发育，有无兔唇，心脏骨骼发育，内脏也是可以看到的，还有是否有脑积水！

Cases of the abnormal sex differentiated diseases in children were presented. Among them, there were 4 cases of Turner's syndrome, 1 Klinefelter's syndrome, 9 female pseudohermaphroditism, 2 male pseudohermaphroditism, and 4 true hermaphroditism.

本文报道小儿性分化异常疾病20例(包括先天性卵巢发育不全综合征4例、先天性睾丸发育不全综合征1例、女性假两性畸型9例、男性假两性畸型2例、真两性畸型4例)，对上述病例进行了细胞染色体核型分析，同时作了口腔上皮细胞性染色质、中性粒细胞核鼓植体及尿17酮类固醇、17羟类固醇的检查。

Pre-school children's eyes in the growth and development has a certain degree of physiological hyperopia, eye development is the normal course of its normal value for :3-4-year-old hyperopia within 200 degrees, 4-5-year-old hypermetropia less than 150 degrees, 6-8-year-old hypermetropia less than 100, more than the normal range, and compared with the abnormal or pathological hyperopia.

学龄前儿童的眼睛在生长发育中有一定的生理远视，是眼发育的正常过程，它的正常值为：3-4岁远视200度以内，4-5岁远视150度以内，6-8岁远视100以内，超过正常范围的，则为异常的或病理性远视。

All cases tested were immunoreactive for S100 and CD34; Mib-1 reactivity was absent to low. Cytogenetic aberrations included chromosome 8 abnormalities in 8 cases, nonspecific numerical abnormalities in 1 case, and a normal karyotype in 1 case. Ten patients had other medical conditions including macrocephaly, seizures, developmental delay, autism, congenital anomalies, Sturge-Weber syndrome, or a family history of multiple lipomas.

免疫组化所标病例均表达S100和CD34 ；Mib-1指数为零或低。8例细胞遗传学显示8号染色体异常，1例显示非特异性染色体数目异常，1例显示正常染色体组型。10例患者伴有其他疾病：巨头畸形、癫痫、发育延迟、自闭症、先天畸形、斯德奇-韦伯综合症、多发性脂肪瘤家族史。

The transforming growth factor-β superfamily, a large group of highly conserved growth factors including TGF-βs, activins and BMPs, regulate a wide variety of cellular functions such as proliferation, differentiation, apoptosis and migration. Signals from these growth factors are transduced by a group of Smad proteins. To date, there are nine vertebrate Smads, including the receptor-activated Smads , Smadsl-3, 5 and 8, the common mediator Smad4 and Smad4β, and the inhibitory Smads, Smad6 and 7. Signaling is initiated when the ligand induces assembly of a heteromeric complex of type Ⅱ and type Ⅰ TGFβ receptors. Then R-Smads are directly phosphorylated by activated type I TGF-β receptors.

在多种SMADS中，SMAD5令我们产生兴趣，基于三个原因：1、Smad5基因敲除胚胎中发现卵黄囊的异位造血以及CFU-GM祖细胞数目增加，表明SMAD5可能是早期造血发育的负向调控基因。；2、应用反义核酸封闭Smad5可以逆转TGF-β对祖细胞增殖的抑制效应，表明它可能介导TGF-β信号转导，后者的异常，包括某些SMADS的功能异常，和白血病紧密相关；3、Smad5基因定位在人染色体5q21，此区域的缺失和急性髓系白血病和骨髓增生异常综合症相关，因此，Smad5被怀疑为白血病抑制基因。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。