发病的

The researches show that the substrate plays an important role in the development of keratoconus. Cornea substrate's agenesis leads to the reduced solidity, which is possibly related to kearatoconus. There is still a lot to be researched on etilogy and early diagnosis of keratoconus.

虽有研究表明角膜间质的水平在圆锥角膜的发病中起重要作用，角膜间质发育不全，导致角膜的稳固性下降，可能与圆锥角膜形成有关，但对圆锥角膜形成的机理仍不详尽，因此，对圆锥角膜的发病机制及早期诊断的研究具有重要意义。

Abnormal expression of type Ⅰ～Ⅵ could be found in the onset of illness. The decreasing of collagen could causes the weaken of the stability of stroma lamellar and the cornea shap to conus. The onset of keratoconus is related to collagen

胶原Ⅰ～Ⅵ型的表达在圆锥角膜的发病过程中有明显的变化，胶原成分的减少会导致角膜的机械抵抗力减弱，并使角膜前凸变薄，最终影响角膜的正常形态，圆锥角膜的发病与胶原密切相关。

Not only it impairs patients" genital health and Quality of life, but also is associated with an increased risk of type 2 diabetes, endometrial carcinoma, hyperlipemia, hyperpiesia, cardiovascular and cerebrovascular events. Up to now, precise pathogenesy of PCOS is yet unknown. The modern medicine indicates the etiopathogenisis of PCOS related to hereditism, endocrinology, immunology, metabolism and so on. The main features are hyperandrogenism and hyperinsulinemia, the correlation and between the above factors and how they inference PCOS are still unclear. In the view point of Traditional Chinese Medicine ,PCOS classifies to "menopathy","infertility" and "Zhengjia , its occurrence exists a close relationship with dysfunction of liver, kidney, spleen and further inducing deficiency, sputum, sluggish stagnant and fire. Many scholars insist that pathogenesis of PCOS is a renal deficiency plus phlegmatic hygrosis. However, after many years clinical observation.

随着研究的不断深入，PCOS日益显示出其复杂性和重要性；他不仅影响到患者的生殖健康及生存质量，而且其异常的激素环境使该类患者对子宫内膜癌、高血压、高血脂及心脑血管意外等病发生危险明显增加；但目前该病的确切发病机制尚不十分清楚，现代医学认为其病因涉及到遗传、内分泌、免疫、代谢等多个方面，以高雄激素血症与高胰岛素血症为主要特征，二者在PCOS发病中的确切作用，目前尚不清楚；PCOS相当于祖国医学的"月经病""不孕""癥瘕"等范畴，本病的发生与肝、肾、脾功能失调导致虚、痰、瘀、火有关。

Nowadays, as more and more attention are paid to glia, which is considered to play an important role in epileptic pathogenesis,In this study, we chose fluoroacetate, a reversible neuroglia metabolic inhibitor as well as a rodenticide that can induce epileptic seizures, to set up a new epileptic animal model by acting on neuroglia to induce seizures.

目前常用的急性化学致痫模型其致痫机制均是作用于神经元，通过对CNS递质的作用来诱发癫痫。虽然，随着胶质细胞在癫痫的发病机制中的作用日益受到关注，但由于缺乏作用于胶质细胞的癫痫模型，使研究胶质细胞在癫痫发病机制中的作用及其与神经元的关系带来了障碍。

Materials and methods: The lung preparation of 6 SARS death patient (died in 9,14,20,29,33,38d) and 6 macaque model (killed in 7,12,14,14, 32, 35d)were objects. Pathological changes, collagen fibers, lattice fibers, elastic fibers, collagen I and III in lungs and fine structure changes were studied by routine H.E dyeing, trigeminy dyeing, trinitrophenol- sirius red staining and polarization microscope, electron microscope and image analysis. Expression of Vimentin、 TGFβ_1、 TNF α、 IL-1β and MMP-2 were detected by immunohistochemistry.Results:1. Pathological changes of SARS death patient.

材料与方法：以6例SARS死亡患者(分别于发病后9、14、20、29、33、38d死亡)和6只猕猴实验模型(分别于染毒后7、12、14、14、32、35d活杀取材)肺标本为对象，应用H.E染色、三联染色、苦味酸-天狼猩红-偏振光法、电镜和图像分析等技术，对比性观察SARS肺组织病理变化和纤维化的病理过程、胶原纤维、网状纤维和弹力纤维的变化特点、Ⅰ型与Ⅲ型胶原纤维的数量和分布规律，旨在探讨SARS肺纤维化的病变经历过程及特点；利用免疫组织化学和形态计量学技术检测SARS死亡患者肺脏的Vimentin、TGFβ_1、TNFα、IL-1β和MMP-2等与炎症反应和纤维化相关活性因子，探讨其发病机制。

Objective:To study children's tuberculosis and the related prevention and treatment Methods: Analyaing 90 children cases with various types of tuberculosis, who were collected from 1991 to 1997Results: The children patients of tuberculosis found in 1996 and 1997 were nerly the total in the past five years The patients in rural areas and in the floating population accounted for 85% Of 33 cases with tuberculose meningitis,17 patients alleviated after the treatment,13 patients automatically discharged and...

目的 ：探讨昆明市儿童结核病发病情况。方法：对我院1991年至1997年收住的各类型结核病患儿90例进行发病情况分析。结果：1996年、1997年两年的患儿46例(51 %)是前5a的总和。其中农村人口及流动人口发病率显著高于城市人口。结论：昆明市儿童结核病发病率呈上升趋势，儿童结核病是成人续发性结核病的根源，尽早发现和治疗儿童结核病是控制结核传播的重要手段

High alcohol intake has been consistently linked to breast cancer risk, but when it comes to other facets of the diet, studies have yielded conflicting results, according to the researchers on the current work, led by Dr. Valeria Edefonti of the University of Milan.

目前已经证实过量引用酒精与乳腺癌的发病风险相关，但食物中的其它成分是否与癌的发病相关，米兰大学的Valeria Edefonti教授认为，目前关于这个问题的研究结果尚不一致。

Compared to the flat culture, cells in 3-D culture more closely mirror what happens in living organisms in morphology, cell alinements, polarization, microenviroments, gene expression pattern and other biological characters. Therefore,3-D culture is useful to investigate the molecular mechanism of nasopharyngeal carcinogenesis.

因与传统的二维培养相比，细胞在三维培养中的形态、排列方式、极性及微环境更接近于体内状态，其基因表达和生物学行为也更接近于体内状态，因而建立能反映鼻咽癌发病不同时期的体外三维培养模型对于鼻咽癌的发病机制研究具有重要价值。

Objective: To observe the repairing effects of Dachengqi decoction on the damage in the network of cholinergic nerve-interstitial cells of Cajal-smooth muscle network of enteric deep muscular plexuses in rats with multiple organ dysfunction syndrome.

多器官功能障碍综合征是继严重感染、创伤、手术、病理产科等原发病发生24 h后，同时或序贯发生的2个或2个以上器官功能失常以至衰竭，以高代谢、高动力循环状态、过度免疫反应为特征的临床综合征，具有发病急、进展快、病死率高的特点，是当前腹部外科危重疾病领域研究的热点和难点。

Methods We detected the adrenocorticotropic hormone and cortisol in the 37 SARS patients from April to June 2003,through the radio-immunity examination in the 9th and 12th month after SARS onset,and investigated the correlation between the levels of plasma adrenocorticotropic hormone , serum cortisol and the glucocorticoid usage.

方法分别对2003年4月至6月天津武警医学院附属医院收治的37例SARS康复患者发病后9、12个月，使用放射免疫的方法随访检测SARS康复患者血浆中促肾上腺皮质激素及血清中皮质醇的质量浓度变化，并与25名正常人比较，观察与发病期间激素总量的关系。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。