发病的

Evidence for a strong inherited component in RA is supported by a lot of data, and about 35% of genetic contribution to RA can be attributed to human leukocyte antigen class Ⅱcomplex.

许多研究表明遗传因素是导致RA发病的最主要原因，而在遗传因素中约35%来自于人类白细胞抗原Ⅱ类复合体。

A missense mutation (2879 A→G) in ADAR gene is detected in the DSH family, which is probably one of the molecular bases of the pathogenesis of the disease.

DSH家系中患者ADAR基因存在错义突变(2879 A→G)，这可能是导致DSH发病的分子机制之一。

More than 90% of the total incidence of typhoid and paratyphoid were typhoid previously, as the widely use of Vi bacterin, in the middle of 90s in 20th century, the popular strain changed, in some provinces the cases of typhoid decreased, but that of paratyphoid increased largely, with the outbreak trend from spot to part and from inshore provinces to backland provinces. In recent years, paratyphoid becomes the main infectious diease in some areas, and ofen develop to serious epidemic situation. So setting up a rapid and accurate detecting metod is necessary.

以前我国伤寒发病占伤寒副伤寒总发病的90%以上，后来由于伤寒Vi疫苗的广泛使用，20世纪90年代中期，流行菌株发生转变，我国部分省份伤寒病例逐渐下降，而由甲型副伤寒沙门氏菌引起的副伤寒病例却大幅上升，并呈现由散发到局部暴发，由沿海省份向内地省份推进的流行趋势，近几年来成为我国一些地区传染病突发事件的主要病种，常发展成重大疫情，急需建立快速、准确的诊断方法。

Through Liaoning Province Taian bills farmers first 35 suspected cases of classical swine fever diagnostic, recorded incidence of death from the process and will have a record of 11 symptoms, and so Autopsy examination step analysis, and later in the Shenyang Agricultural University Veterinary College pastoral guidance from the laboratory diagnosis, through production observation, classical swine fever virus onto the world body immune reaction, Enzyme linked immunosorbent assay testing, and made with Erysipelas ,Swine plague, Streptococcosis suis , and Mycoplasmal pneumomia of swine, Swine Toxoplasmosis , and ultimately determine the reasons for the cause of classical swine fever virus incidence.

本人通过对辽宁省台安县某农户的35头猪瘟疑似病例进行诊断，记录了从发病到死亡的过程，并且将所出现的症状一一记录，对死亡的猪挑选了3头进行剖检做近一步分析，对疑似病症进行分析排除。之后提取病料并保存，在沈阳农业大学畜牧兽医学院赵玉军教授的指导下进行了实验室诊断，通过涂片观察、猪瘟病毒兔体交互免疫反应、酶联免疫吸附实验，并做出了与猪丹毒、猪肺疫、猪气喘病、猪链球菌、弓形虫病的鉴别诊断，最终确定为此次引起发病的原因为猪瘟病毒。

Experimental studiesThis experiment adopts the chronic serum sickness MsPGN animal model improved and combine it with damp and hot model to establish experimentalrat foundation that contain deficiency of Yin and damp and hot . Compared the biochemisty and organizing such index as the shape , etc at the different stage of the model metioned above with those facts of MsPGN rat to find out the relationship between deficiency of Yin damp and hot and MsPGN on the development of illness and the role in MsPGN course, know the disease machine of MsPGN and treat MsPGN for Chinese medicine, screen the effective square medicine and establish the experiment foundation.

实验研究本实验采用改良的慢性血清病MsPGN动物模型，将其与具有一定实验研究基础的大鼠阴虚，湿热证模型有机结合起来，建立大鼠实验性MsPGN阴虚湿热蕴结证的病证结合模型，通过与单纯实验性大鼠MsPGN模型不同造模阶段的生化、组织形态等指标的比较，探讨阴虚湿热蕴结与MsPGN发病的关系及其在MsPGN发病过程中的作用，为中医认识MsPGN的病机及治疗MsPGN，筛选有效方药奠定理论基础。

It has been thought that the complicated gene-gene interaction, heterogeneity of clinical presentation and numerous farraginous experimental data make it more difficult to draw a firm conclusion with genetic research work.

这主要是因为精神分裂症临床分型复杂，症状多样，若将不同类型的患者混杂起来研究将难以对这种异质性疾病作出可信的结论；同时该病作为多基因病的一种，其发病是由许多微效基因共同作用决定的，若孤立地研究某个候选基因或候选染色体区域与疾病的关系，也难以得出满意的结果；而且在研究结果的分析中，某个基因对发病的微小贡献将被&淹没&在巨大的数据信息中，难以提取。

In recent years, with social development, the variety of the public esthetic sense, patients of the gastroptosis presents younger and its occupation scope also expands gradually.

近年来，随着社会的发展，大众审美观的变化，胃下垂的发病特点呈现年轻化趋势，发病的职业范围也逐渐扩展。

If the second signal overstimulate, T lymphocyte cells may be over- activated and lead to immune disorder.

本研究从共刺激分子在哮喘外周血表达和细胞因子的变化出发，分析它们与哮喘发病的相关关系，研究哮喘发病的可能免疫机制，为判断病情变化和临床哮喘的治疗提供理论依据。

The transition from the systemic inflammatory response syndrome to seere sepsis and septic shock inoles a myriad of pathogenic changes, including circulatory abnormalities that result in global tissue hypoxia.1,2 These pathogenic changes hae been the therapeutic target of preious outcome studies.12 Although this transition occurs oer time, both out of the hospital and in the hospital, in outcome studies interentions hae usually been initiated after admission to the intensie care unit.12 In studies of goal-directed hemodynamic optimization, in particular, there was no benefit in terms of outcome with respect to normal and supranormal hemodynamic end points, as well as those guided by mixed enous oxygen saturation.9,13 In contrast, een though we enrolled patients with lower central enous oxygen saturation and lower central enous pressure than those studied by Gattinoni et al.9 and with a higher lactate concentration than those studied by Hayes et al.,13 we found significant benefits with respect to outcome when goal-directed therapy was applied at an earlier stage of disease.

从全身炎症反应综合征转为严重脓毒症和脓毒性休克牵涉大量发病的变化，包括导致全身性缺氧的循环紊乱。这些发病的变化成为先前结果研究的治疗学目标。尽管这些转变随着时间的流失而逐渐出现，既可以在院外，也可在院内，在结果研究中，干预措施往往在进入ICU之后才启动。特别的，在那些目标导向血流动力学最优化研究中，依照结果，那些以正常或超正常血流动力学为终点的措施未能显示出益处，以混合静脉血氧饱和度为导向的研究同样如此。

There are unique cognitive in pathogenesis of gallstones and a variety of ways to treatment in traditional Chinese medicine.

祖国医学对胆结石的发病机制和治疗手法有独特的认识和多样的方式，在胆结石发病的不同阶段可以采用不同的方式治疗，并且可以采用多种方式联合以提高疗效。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。