发病

The dopamine release in vivo was monitored by fast cyclic voltammetry and the concentrations of DA and its metabolites dihydroxy-phenylacetic acid and homovanillic acid were determined by high performance liquid chromatography electrochemical detection in the process study. In addition, the effects of some traditional Chinese herbs and related marine drug on behavioral changes were also evaluated in order to provide some suggestive clue for rational drug design of anti-Parkinon's disease .

许多因素都参与PD的DA能神经元的死亡，所以，本研究在制备PD动物模型的基础上，应用国内率先引进的快速周期伏安法检测设备在体动态监测DA的释放，同时应用另一种电化学检测技术—高效液相色谱电化学检测法离体检测DA及其代谢产物二羟苯乙酸和高香草酸的含量，结合行为学测定及其它方法，研究了雌激素和铁在PD发病中的作用，以及一些药物，如吲哚醌、牛磺酸、铁离子螯合剂、胆囊收缩素（CCK-8）、乌鸡白凤丸有效成份、大豆异黄酮及海洋酸性寡糖HSH971，对DA能神经元的影响，从DA能神经递质角度对PD的发病机理提供进一步的实验依据，并为PD的预防和治疗提供新的干预措施。

Observe the effect of Fuling Gancao Decoction on gastric liquid emptying and content of nitric oxide and acetylcholine esteras in the gastric fundus,antrum and duodenal tissu of functional dyspepsia rats and investigate the mechanism.1 Reference reviewThe reference review discussed the source of disease name of TCM for FD,etiology and pathogenesis of TCM,selection of therapeutic methods by different stages or according to the differential syndrome diagnosis,advance on the clinical and experimental research as well as the problems lying in the research of TCM and corresponding strategies.We also have summarized the recent research progresses on the FD.In the meanwhile,we further exploited the pathologic characteristics,diagnosis and treatment of FD;summarized etiology and pathogenesis of TCM for FD and application of Classical Prescriptions in clinical and experimental study;Collected and arranged the Literatures and summarized the recent research progresses of Fuling Gancao Decoction;Finally, collected and arranged the literatures of proved cases and clinical experiences of Fuling Gancao Decoction.2 Theoretical studyThe Theoretical study first discussed the source of TCM for stomach deficiency and congestion of fluid-retention in syndromes of FD;Secondly, summarized the indications of Fuling Gancao Decoction,that is:①epigastric throb,②cold hands and feet in syncope,③hydroadipsia,④gastric blockade,⑤gastric splashing sound,⑥no desire for drinks,⑦light white tongue,thin-white and smooth fur,⑧deep and wiry pulse are the indications of Fuling Gancao Decoction;Subsequently,analyzed the composition of Fuling Gancao Decoction,considered that ginger is the main drug which treating congestion of fluid-retention in Middle-Jiao by Zhang Zhongjing.3 Experimental study3.1 Experiment oneObjective:To establish the animal model of FD with delayed gastric liquid emptying and evaluat it.

同时观察茯苓甘草汤对FD大鼠胃液体排空及胃底、胃窦及十二指肠中乙酰胆碱酯酶、一氧化氮含量的影响，探讨茯苓甘草汤的作用机制。1文献综述参照古、今中医有关文献对FD的中医病名、病因病机、辨证论治方法、临床及实验研究进展进行了探讨，并对现代医学在FD研究中所取得的(来源：A0bBC论文网www.abclunwen.com)进展进行了总结，进一步明确了FD的发病机制、诊断和治疗的研究进展；总结了中医对FD的病因及发病机制、中医诊断及经方治疗FD临床及实验研究进展；并搜集和整理已发表的有关茯苓甘草汤研究报道，阐述了茯苓甘草汤的现代研究进展；最后搜集和整理了近现代著名医家应用茯苓甘草汤的经验及验案。2理论研究理论研究部分首先对功能性消化不良胃虚饮停证的认识进行了理论溯源；其次对茯苓甘草汤的适宜证象进行总结，认为：①心下悸，②四肢不温，③口不渴，④胃中痞满，⑤胃中振水音，⑥不欲饮水，⑦舌淡白，苔薄白而滑，⑧脉沉弦是茯苓甘草汤的主证；随后对茯苓甘草汤方药组成解析，认为生姜是仲景治疗中焦饮停的一味主药。3实验研究3.1实验一目的：探讨建立功能性消化不良胃虚饮停证的动物模型方法并对其进行评价。

Its pathologic characteristics of indiscoverable growth and poor differentiation leads to the clinical figures, such as the difficult diagnosis in early stage, lower rate of redical resection, and insensitive to chemotherapy or radiotherapy, and in the end, the treatment efficacy of PGC has not been markedly improved for many years.

原发性胆囊癌占我国胆道肿瘤发病的第一位，其发病隐匿，早期诊断困难，恶性程度高，根治性手术切除率低，对化疗和放疗均不敏感，多年来疗效未能明显改善。

Results Of the 35 cases, there were 5 monolocular cysts and 30 multilocular cysts; 39 lesions were found, including 19 lesions in 15 serous cystadenomas and 20 lesions in 20 mucous cystadenomas. The cystic wall was generally thin and regular, and sometimes nodular. The multilocular cysts were multihole, broken netlike or polycircular, and showed the irregular signals, while the monolocular cysts showed the uniform signals.

结果 35例共有39个囊灶，其中15例浆液性囊腺瘤共有19个病灶（4例双侧卵巢发病）；20例粘液性囊腺瘤均为单侧发病（包括交界性囊腺瘤3例）。5例为单囊病灶；30例为多囊多房性病灶，囊内有分隔，呈多房、破鱼网状、囊套囊状等，囊腺瘤囊壁一般较薄且规则，囊壁可有壁结节；单囊病灶信号均匀，多囊多房性病灶信号多不均匀。

Asymmetric dimethylarginine and monomethyl arginine are endogenously produced amino acids that inhibit all three isoforms of nitric oxide synthase.

点评：内皮一氧化氮以及一氧化氮合酶是目前门静脉高压症以及相关并发症的发病机制的研究热点之一，本文研究了抑制NOS的内源性氨基酸类化合物的清除酶—-二甲基精氨酸–二甲氨基水解酶，进一步的深入探究了这一发病机制，为今后治疗作用位点的选择、药物研发以及相关实验研究提供了一定的理论依据，个人认为该实验意义较大。

The distribution of acute virus necrobiotic disease virus in mantle, gill, hepatopancreas, kidney, intestine and muscle of scallop Chlamys farreri naturally diseased and artificially infected was detected by ultra thin section electron microscopic technique, negative staining electron microscopic technique and ELISA.

应用超薄切片、负染电镜技术以及ELISA对自然发病和人工感染发病的栉孔扇贝之外套膜、鳃、肝胰腺、肾、肠、及闭壳肌等主要器官急性病毒性坏死症(AcuteVirusNecrobioticDisease，AVND)病毒的感染状况进行了研究。

Background and ObjectiveVitiligo is a kind of disease characterized by the depigmentation of the skin and hair because of acquired melanocytes damage. At present, the pathogenesis of vitiligo remains unclear, but many domestic and abroad researches have proved that vitiligo may be related with heredity, immunity and nerval elements.

一、研究背景和目的白癜风是一种获得性黑素细胞破坏所致皮肤和毛发色素脱失，其发病机制目前尚不清楚，国内外大量研究表明，该病发病机制可能与遗传、免疫、神经等方面有关。

Explore the incidence and high risk factors of late-onset noninfectious pulmonary complications.

及迟发性非感染性肺部并发症的发病情况，发病的高危因素。

Methods:The plasma ADM levels were detected by radioimmunoassay in HDP,normal pregnant women and normal nonpregnant women.

对其发病原因众说纷纭，普遍认为内皮损伤是妊娠期高血压疾病发病的中心环节。

According to the results of gel elecrophosis, the base group was divided into viriation group and nonvariation group.

由于2型糖尿病发病机制复杂，但胰岛素抵抗和胰岛β细胞功能下降是其重要发病原因。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。