发生生物学

The negative correlation was observed between S100A4 expression and Ecad expression (r=-0.385, P.05) CONCLUSION: The correlated expression of S100A4 and Ecad is closely related to the development of epithelial ovarian carcinoma,which is valuable markers in predicting biological behavior and trend of metastasis in epithelial ovarian carcinoma.

S100A4和Ecad的相关表达与上皮性卵巢癌的发生发展关系密切，是判断上皮性卵巢癌生物学行为、预测侵袭转移的重要指标。

Pentylenetetrazol is a central nervous system drug that induce chronic and acute epilepsy model to study epileptogenous mechanism .Kindling is a natural epileptogenous phenomenon.

我们前期研究工作发现：应用电镜、Timm染色等从形态结构方面已证实在点燃前神经元发生了可塑性改变包括苔藓纤维芽生，新突触形成(突触密度增大或数量增多)与突触重排等，但这些只是一个初步探索，仍不能够说明问题的全部，如其分子生物学基础、神经元凋亡情况等尚不清楚，需进一步研究探讨。

Objective To research the biological significance of the expression of PTEN in esophageal carcinoma.

目的研究PTEN蛋白表达在食管癌发生发展中的生物学意义。

The author also presents the following phenomena which must have significant implications on the mental health of children in many countries in Asia . 1 Nuclearization of the family system and alarming increase of divorce, 2 Reduction of the number of children in a family, 3 Rising number of working mothers and women ? s equal right movement, 4 Lack of opportunity for parents to learn how to raise a child, 5 Steep competition and exclusive emphasis on scholastic achievement in school, 6 Marked changes in value orientations from traditional to modern ones, 7 Confusing and often contradictory advices by "experts" and "professionals" on child rearing and child education, 8 New tides of globalization and confounding co-existence of multi-cultures in most countries and emergences of virtual world, IT and BT industry in some advanced countries, resulting in new forms of psychopathology such as 'internet addiction' and extreme social isolation.Implications of these findings in terms of interventions and prevention for mental health children in developing countries are discussed in developmental, ecological and ethological points of view.

作者提出在大多数亚洲国家存在儿童抚养问题危机，主要依据以下观察：①避孕和意外怀孕②逃避和拒绝抚养，虐待儿童，遗弃幼童③不恰当的早期抚养④不恰当的/不够充分的教育，过度保护和过度控制⑤性别角色和态度改变⑥对智力发展拔苗助长以及学习成绩的压力作者还提出了以下几种现象，它们与亚洲国家的儿童精神健康有着密切关联：①家庭体系核心化和令人担忧的离婚率猛增②家庭成员中儿童数量的减少③职业妇女做母亲及妇女解放运动的兴起④父母亲抚养孩子经验不足⑤学校对学习成绩的过分强调合潜在的竞争压力⑥传统价值观在现代化的冲击中发生明显的变化⑦所谓&专家&和&权威人士&对孩子抚养和教育的观点众说纷纭⑧全球化新潮及多种文化共存的问题，虚拟世界的出现，发达国家 IT 、 BT 工业引发新型精神病理现象如&网络成瘾&和极端的社会隔绝根据这些发现，如何干涉和预防发展中国家的儿童精神健康问题，我们将从精神发育、生物学、行为学观点进行阐述。

Nuclearization of the family system and alarming increase of divorce, 2 Reduction of the number of children in a family, 3 Rising number of working mothers and womens equal right movement, 4 Lack of opportunity for parents to learn how to raise a child, 5 Steep competition and exclusive emphasis on scholastic achievement in school, 6 Marked changes in value orientations from traditional to modern ones, 7 Confusing and often contradictory advices by "experts" and "professionals" on child rearing and child education, 8 New tides of globalization and confounding co-existence of multi-cultures in most countries and emergences of virtual world, IT and BT industry in some advanced countries, resulting in new forms of psychopathology such as 'internet addiction' and extreme social isolation.Implications of these findings in terms of interventions and prevention for mental health children in developing countries are discussed in developmental, ecological and ethological points of view.

作者提出在大多数亚洲国家存在儿童抚养问题危机，主要依据以下观察：①避孕和意外怀孕②逃避和拒绝抚养，虐待儿童，遗弃幼童③不恰当的早期抚养④不恰当的/不够充分的教育，过度保护和过度控制⑤性别角色和态度改变⑥对智力发展拔苗助长以及学习成绩的压力作者还提出了以下几种现象，它们与亚洲国家的儿童精神健康有着密切关联：①家庭体系核心化和令人担忧的离婚率猛增②家庭成员中儿童数量的减少③职业妇女做母亲及妇女解放运动的兴起④父母亲抚养孩子经验不足⑤学校对学习成绩的过分强调合潜在的竞争压力⑥传统价值观在现代化的冲击中发生明显的变化⑦所谓&专家&和&权威人士&对孩子抚养和教育的观点众说纷纭⑧全球化新潮及多种文化共存的问题，虚拟世界的出现，发达国家IT、BT 工业引发新型精神病理现象如&网络成瘾&和极端的社会隔绝根据这些发现，如何干涉和预防发展中国家的儿童精神健康问题，我们将从精神发育、生物学、行为学观点进行阐述。

Its pathologic mechanism has the close relation to high blood sugar, the excrescent of kidney blood dynamics and the household hereditary, etc. Following the improvement of molecular biology, in recent years, many people discovered that many varieties of cell factors take part in the process of DN and exertive important functions.

近年来随着分子生物学技术的进步，研究发现有多种细胞因子参与DN的发生发展过程，其中以转化生长因子、血小板衍化生长因子为核心因子，其作用涉及到肾小球血流动力学改变、细胞外基质代谢、细胞增殖和细胞肥大等诸多方面。

A gene sequence of the anthropogenic adiponectin spherical fragment obtained by the invention absolutely accords with a known gene sequence, and compared with the full-length adiponectin, the hydrolyzed anthropogenic adiponectin spherical fragment has stronger biological activity, fast reaction after dosage, good bioavailability and better clinic application prospect, especially when the diabetes patient receives a recanalization treatment after a myocardial infarction, the anemically myocardial damage of the diabetes patients can be eased by the exogenetic dosage.

本发明公开了一种人源性脂联素球状片段用于治疗糖尿病缺血性心脏病药物的应用，本发明所得到的脂联素球状片段的基因序列与已知的基因序列完全相符，与全长的脂联素相比，其水解以后的脂联素球状片段有着更强的生物学活性，而且给药后反应迅速，生物利用度好，有着更好的临床应用前景，特别是对糖尿病患者在发生心肌梗死后接受血管再通治疗时，通过外源性给药，以减轻糖尿病患者缺血心肌损伤。

In this paper, the biological characteristics of florescence, spikelet and inflorescences structure, morphogenesis formation of inflorescence, megasporogenesis and the development of female gametophytes were studied systematically by using anatomy structure, scanning electron microscopic and paraffin section methods. The results were as followed:(1) Phyllostachys praecox was the bamboo flowering fragmentarily; the cultivation changed the characteristic of flowering; the plantlets of flowering were complex and splitted into three kinds: the plantlet flowering before continued flowering; the plantlet flowering before stopped flowering and the plantlet changed into flowering. The inflorescence of Ph. praecox was indefinite inflorescence or called false inflorescence, and actually it was flower stress structure. Its basal unit was pseudospikelet with two kinds: apical spikelet and lateral spikelet. The floret had one lemma, one pelea, three stamens, one pistil and three lodicules.

本研究综合运用形态解剖学、扫描电镜、石蜡切片等技术手段，对雷竹花期生物学特性、小穗与花序构造、花序形态建成过程、大孢子发生与雌配子体发育等进行了较为系统的研究，结果表明：(1)雷竹为零星开花竹种，耕作条件对其开花特性具有重要影响；开花植株类型复杂多样，可以分为以前开过花现在继续开花、以前开过花现在停止开花以及以前未开过花现在转为开花等3种类型；雷竹花序为无限制花序或称&假花序&，实为花枝结构，基本单位为&假小穗&；假小穗有顶生和侧生之分；小花具内外稃各1枚，雄蕊3，雌蕊L，另具3枚大小不等之鳞被。

Methods:The clinical and pathological data of one child case were summarized, and the characteristics of incidence, biology, pathology, diagnosis and surgery were analyzed with literature review. Results: It was diagnosed as ganglioneuroma of lymph node by pathology examination.

回顾分析1例发生在小儿淋巴结的节细胞神经瘤的临床病理资料，结合文献对其发病情况、生物学特性、临床、病理诊断及手术原则进行讨论。

Subsequent molecular studies discovered that this mutation led to gain-of-function of GATA 2, partly blocking myelo-monocytic differentiation and resulted to acute transformation of CML.

随后的分子生物学研究结果提示该突变导致获得性GATA-2功能增强，部分阻滞了CML髓系祖细胞的分化，为慢粒发生恶性转化提供了重要的分子学证据。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。