发生中的

Objective: To investigate the role of p16 gene aberrant methylation in the malignant progression of human bladder cancer.

目的：研究膀胱移行细胞癌中p16基因甲基化失活及其在肿瘤发生中的作用。

In the present study, we investigated the role of epicardium-derived cells in annulus fibrosis formation and the occurrence of APs.

在本研究中，我们研究了心外膜起源细胞，在纤维环形成以及房室旁路发生中的作用。

Genes important for male gametogenesis involved in highly con-served landmark events such as meiotic recombination, formation of the synaptonemal complex, sister chromatid cohesion, spermiogenesis during postmeiotic stages, and checkpoints and factors required for the meiotic cell cycle .

精子发生中的重要基因与一系列精子发生过程中阶段性的细胞事件密切相关，例如减数分裂重组、联会丝复合物的形成、姊妹染色体的结合、减数分裂后精子的变态以及减数分裂周期中的关键点和必需因子等。

These results provide a new proof of AR participating in the regulation of oogenesis development. 4. The immediate early-gene c-fos palys an important role in cell multiplication and differentiation.

这是我们首次在白蚁卵子发生过程中发现AR，并对非繁殖蚁和繁殖蚁生殖细胞发育的激素调节进行了对比，为进一步探讨AR在昆虫卵子发生中的调节机制提供了依据。

Summary Apoptosis is a common phenomenon during spermatogenesis, and its dysregulation has been associated with male infertility.

凋亡是精子发生中的普遍现象，凋亡的失调控被认为与男性不育的发生有关。

The cloning and identification of these genes are of great value to elucidate the mechanism of spermatogenesis and spermiogenesis.

发现并研究精子发育不同阶段表达的基因及其调控因子，深入研究它们在精子发生中的作用，将有助于阐明精子发生的机理，为探索不育机理和寻找免疫避孕的新途径奠定理论基础。

The cloning and identification of these genes are of great value to elucidate the mechanism of spermatogenesis and spermiogenesis. Such study can also provide foundation and cues to investigate the mechanism of infertility and immunocontraception.

发现并研究精子发育不同阶段表达的基因及其调控因子，深入研究它们在精子发生中的作用，将有助于阐明精子发生的机理，为探索不育机理和寻找免疫避孕的新途径奠定理论基础。

To investigate the disorder of Wnt signal transduction pathway in tumorigenesis, we studied the adenomatous polyposis coli gene and β-catenin gene mutations in desmoid-type fibromatosis.

本研究分析了韧带样型纤维瘤病中APC和β-catenin基因突变，探讨Wnt通路中APC/β-catenin基因异常在肿瘤发生中的作用。

Objective: To investigate the effect of nonstructural protein 4B in hepatitis C Virus (HCV NS4B) on apoptosis in hepatic cell, and to study the role and mechanisms in development of hepatocellular carcinoma.

目的：探讨丙型肝炎病毒非结构蛋白NS4B在原发性肝癌发生中的作用，及其发生机制。

Between women with or without endometriosis, the expression of VEGFmRNA of eutopic endometrium in the secretoiy phase was significantly higher than that in the proliferative phase(P.05). eutopic endometrium of women with endometriosis both in the proliferative phase and secretoiy phase expressed higher level VEGFmRNA than that in control group(P.05). Conclusion:①The expression of VEGF is adjusted by female'hormone.②VEGF is a very important factor that may contribute to the pathegenesis of endometriosis by promoting neovascularization,explanting of ectopic endometrium , increasing activity of angiopoiesis in eutopic endometrium③VEGF is a efficient organism maker to reflect invading growth, prognosis and metastasis potency of EMs.④VEGF may paly an important role in both pathogenesis and progress of endometriosis.

EM 患者VEGF 水平受女性性激素周期性调节；VEGF 是导致EM 发生特别是在位内膜血管活性增强、异位内膜种植、新生血管形成的重要机制，提示血管生成是EMs 发生中的一个重要因素；VEGF 可能不仅参与EM 的形成，并与进一步发展存在关系，提示血管生成在异位子宫内膜的种植、浸润中可能起着重要的病理生理作用，是EM 发病的必要环节；VEGF 是反映EM 侵袭生长、转移潜能、预后的有效生物指标，提示通过使用抗血管生成药物或抗血管生长因子抗体，来阻断血管生成，极有可能成为EM 在现有药物和手术治疗基础上的一种有效治疗策略和靶点。

They weren't aggressive, but I yelled and threw a rock in their direction to get them off the trail and away from me, just in case.

他们没有侵略性，但我大喊，并在他们的方向扔石头让他们过的线索，远离我，以防万一。

In slot 2 in your bag put wrapping paper, quantity does not matter in this case.

在你的书包里槽2把包装纸、数量无关紧要。