发现

When the frequency of codon usage of citrus was compared to Homo sapiens, Drosophila melanogaster, Saccharomyces cerevisiac and Escherichia coli, we found that the codon preference is considerably different between citrus and non-plant species. While compared to Arabidopsis thaliana, Lycopersicon esculentum, Oryza sativa and Musa acuminata, we found that the codon preference was identical in dicotyledons, but was different between citrus and monocotyledon, Oryza sativa and Musa acuminate.

将柑橘的密码子使用频率与人、果蝇、酵母和大肠杆菌等不同种类模式生物比较后发现，柑橘密码子的偏爱性与不同种类生物有不同程度的差异；但将柑橘的密码子使用频率与拟南芥、番茄、水稻和尖叶蕉等不同种类的植物相比，发现柑橘密码子的偏爱性与同为双子叶植物的拟南芥、番茄完全一样，而与水稻、尖叶蕉这2种单子叶植物均有较大的差异。

Of 232 persons,eleven have abnormal shadows in their lungs ;one has lymphadenectasis ;sputum smear acld-fast strain and cultivate were negative ;serum and antitubercle antibody was positive.

来自城镇地区学生的PPD反应阳性率为55.03％，明显高于来自农村地区的学生42.78％（u=7.66，P（o.01），大学生结核病的发现率为0.18％；农民工的PPD反应阳性率55.81％，结核病的发现率0.53％。

Among all, deleted in liver cell (DLC-1) gene was found to play an important role in hepatoma in 1998, and after that hypermethylation on the promoter of the DLC-1 gene was found in many other cancers, suggesting that epigenetic modification is another way to control the carcinogenesis. Another gene, Endothelin type B receptor, was found to cause megacolon syndrome by accident while searching the cause of white spot in mouse, and was also found hypermethylation on its promoter in some cancer cells.

在此中，DLC-1基因自从1998年后被发现在肝癌的演化上扮演重要的角色后，在许多其他的癌症上也发现此基因上位於promoter的CpG islands有过度甲基化的现象，推论DLC-1基因的过度甲基化是一种经由epigenetic modification调节细胞癌化的方式。

Our previous studies have shown that ubiquitous overexpression of HmgD caused hemocytes proliferation and the formation of melanotic tumors in the Drosophila larvae. To clarify the mechanism of melanotic tumors appearance,we also generated RT-PCR analysis to test the transcriptional changes of PPAE and Spn27A,which encode the key factors in the phenoloxidasecascade pathway from larvae samples of mid-third instar,late-third instar and prior to pupation relative to wild type flies.Our result showed that in the HmgD overexpression mid-third instar larvae,the expression level.of Spn27A was lower than wild type,otherwise the expression level of PPAE was higher than wild type.It suggests that overexpression of HmgD affects the PO cascade pathway.

本研究组前期工作发现，过量表达HmgD引起果蝇幼虫体内血细胞增生，并出现黑色素瘤，为探讨HmgD过量表达导致了血细胞增生即形成黑色素瘤的分子机制，本研究分别提取三龄中期、后期和相对于野生型化蛹前时刻的幼虫的RNA，首先检测了编码酚氧化酶级联反应途径中的两个关键基因PPAE，Spn27A在突变体中的转录发生变化，结果发现，Spn27A在三龄中期的表达量低于野生型，而PPAE的表达高于野生型，表明过量表达HmgD影响了酚氧化酶级联反应途径，低水平的Spn27A不足以抑制PPAE的活性，活化的PPAE催化了PPO的活性，使其转变成有活性的PO，从而促进黑色素的生成，使果蝇体内产生黑色素瘤。

Abstract］ objective to discuss ultrasound diagnosis on fetal abnormal.methods we examined 1 231 example pregnant women carried on the prenatal with ultrasonography and the color ultrasonography.results picked out the fetal abnormal 9 examples,in which anencephaly were 2 examples,the hydrocephalus 3 examples,the meningocele 1 example,the endocardial cushion defects 1 example,the ectopiacordis accompanied grastroschisis 1 example,the cleftlip 1 example.all patients were confirmed through induced labor.conclusion fetal abnormal ultrasonography image is typical,the careful inspection correct analysis can discover promptly,ultrasonography is the first method to inspect the fetalabnormal,may achieve the prompt discovery,prompt termination of pregnancy item.

目的 探讨超声检查对胎儿畸形的诊断价值。方法对1231例孕妇进行产前超声检查。结果检出胎儿畸形9例，其中无脑畸形2例，脑积水3例，脑膜膨出1例，心内膜垫缺损1例，心脏外翻并腹壁大缺损1例，唇裂1例。所有患者均经引产后证实。结论胎儿畸形的声像图比较典型，细心检查正确分析能及时发现，超声是检查胎儿畸形的首选方法，可达到及时发现及时终止妊娠的目的。

A cDNA segment was isolated from M. meretrix larvae. The results of caspase in situ detection in larval developmental stages revealed that there were activated caspase from L1 to L3, indicating caspase is involved in the whole developmental process. The main apoptosis area was found in velum at L3 before metamorphosis, indicating the degradation of velum might be the process of apoptosis. The larvae before metamorphosis were treated by caspase specific inhibitor to analyze the role of caspase in this process. The results indicated that caspase have function metamorphosis.

根据caspase在不同物种中的保守区域设计简并引物，在文蛤幼虫中扩增到cDNA序列片段；检测有活性的caspase在文蛤幼虫各发育时期的分布部位，发现其在L1至L3期幼虫中都有分布，说明整个幼虫形态变化过程中都有caspase的参与；细胞凋亡检测结果显示，幼虫主要发生细胞凋亡的部位在L3期幼虫的面盘，即变态过程中要退化的器官，说明细胞凋亡可能是文蛤幼虫变态过程中面盘退化的主要机制；用caspase特异性抑制剂处理变态前幼虫，发现幼虫变态率下降，初步验证了caspase在文蛤幼虫变态过程中的作用。

Metabolon, Inc.(Research Triangle Park, NC, USA) is leading the discovery of biomarkers through the use of metabolomics, a powerful and new scientific approach for the discovery and development of drugs and the early diagnosis of disease.

Metabolon公司(Research Triangle Park， NC， USA)一直致力于研究蜕变中间产物来发现生物指标，这是发现和开发药物和疾病早期诊断的强有力的新方法。

By dehydrochlorination reaction the poly[(2-methoxyl-5-octyloxy)phenylene vinylene] is synthesized and the material"s structure is characterized by nuclear magnetic resonance spectroscopy, infrared absorption spectrum, ultraviolet and visible spectrophotometry. At the meantime, the fluorescence spectrum is measured and the mechanism of fluorescence occurring is analyzed. Thermal Gravimetric Analyzer"s results show that the MO-PPV"s thermal stability is fine. Also the experiment of resolvable property indicates that the MO-PPV can well dissolve in chloroform. Through analyzing the film"s surface by Metaloscope and Atomic Force Microscope, the good filming is found.

通过脱氯缩合法合成了聚(2-甲氧基-5-辛氧基)对苯乙炔，并分别用核磁共振波谱法、红外吸收光谱法、紫外-可见分光光度法等对其进行了结构表征；测量了样品的荧光光谱，分析了荧光产生的机理；热失重仪分析了材料的热稳定性，研究表明MO-PPV材料具有良好的热稳定性；溶解性实验发现材料在氯仿中溶解性较好；金相显微镜和原子力显微镜研究了薄膜的表面形貌，发现该材料的成膜性良好；材料的导电性研究表明，固体材料在掺杂下才可以表现出导电特性，而配成溶液的材料导电性因溶剂的不同而不同，并随溶解时间的长短发生变化。

Secondly, the silver based catalysts modified by phosphorus, zirconium, zinc, potassium and so on using molecular sieve as carrier, which were produced by ion-exchange method, had also good catalytic performance for 1,2-propane glycol oxidation to methylglyoxal. The conversion of 1,2-propane glycol and the selectivity of methylglyoxal were both high, and the impurity such as formaldehyde and acetaldehyde in the product is little. At the condition of the temperature 300 ℃, the molar ratio of oxygen to 1,2-propane glycol 1.7:1, the space velocity 6000h~(-1), and the concentration of 1,2-propane glycol 70wt%, the conversion of 1,2-propane glycol is 90% and the selectivity of methylglyoxal is 45% on the Ag-P catalyst.

其次对采用离子交换法制备的负载在分子筛上的银系催化剂进行了研究，发现此催化剂在助催化剂磷、锆、锌、钾等的作用下对丙二醇的低温氧化脱氢具有很高的活性，可以得到较好的丙酮醛的收率，并且产物中的甲醛、乙醛副产物的量比较低；经过对Ag-P催化剂上反应条件的考察，发现当温度为300℃、氧醇比1.7：1、空速6000h~(-1)、丙二醇浓度为70wt%时，丙二醇的转化率为90%，丙酮醛的选择性为45%。

The results showed that there was hybridization signal on metaphase chromosome and interphase nucleus of human,but no signal on metaphase chromosome and interphase nucleus of Microtus mandarinus.According to the results,we discussed the homologue between pY3.4 in Y chromosome of humanbeing and DNA of Microtus mandarinus and FISH result of Microtus mandarinus.

结果显示，人的中期染色体上和间期细胞核中发现了杂交信号，棕色田鼠的未发现杂交信号，由此讨论了棕色田鼠DNA与人Y染色体pY3.4的同源性和棕色田鼠的FISH结果，以便进一步研究棕色田鼠Y染色体。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。