发现

Only one subject with cyanotic CHD had iron-depleting problem, whereas none was observed in the children with noncyanotic CHD.

仅有1位发绀型病童发现有铁贮存耗尽的问题，而在非发绀型病童中并未发现。

Since we have discovered vessels in Cycadaceae and Zamiaceae in former times,so we have discavered vessel in all families of Cycadopsida.

由于此前本项目组已经在另2个科的代表种中发现了导管，因此，至此就已经在苏铁纲所有3个科中全部发现了导管。2。

The European Union has detected a similar trend in several European countries, as has CyclOpe, the research institute.

欧洲联盟的几个欧洲国家已经发现了类似的趋势，CyclOpe研究所也有类似发现。

The final diagnoses of 12 patients were confirmed aschronic myeloid leukemia. The clinical diagnoses of another 2 pa-tients were acute myeloid leukemia, and the other 1 was secondarypolycythemia. Cytogenetically, the Ph~1 chromosomes were found among 11 of 12 pa-tients with CML, the mean of Ph~1 positive cells was 72.3%. The presenceof P...

在12例慢性粒细胞白血病中，11例Ph~1染色体为阳性(阳性率平均为72.3％)，1例为Ph~1阴性；2例急性粒细胞白血病患者的骨髓中期分裂细胞具Ph~1染色体者分别占1/4及1/5，其中1例还发现微小体；1例继发性红细胞增生症患者，70％的骨髓中期分裂细胞为Ph~1染色体阳性，并发现染色体碎裂细胞。

Among the fish which were cytogenetically studied, most of them do not possess any morphologically differentiated sex chromosomes. On the other hand, karyotypic analysis, chromosome binding, synaptonemal complex observation and comparative genomic hybridization show in few fish species, that there exist sex chromosomes which differentiated at different levels and types.

在进行过细胞遗传学研究的鱼类中，绝大部分没有发现异形性染色体，然而通过核型分析、染色体显带、联会复合体观察和比较基因组杂交等方法，发现在少部分鱼类中确实存在有异形分化的性染色体，并且分化程度高低不等，性别决定方式多种多样。

The final diagnoses of 12 patients were confirmed aschronic myeloid leukemia. The clinical diagnoses of another 2 pa-tients were acute myeloid leukemia, and the other 1 was secondarypolycythemia. Cytogenetically, the Ph~1 chromosomes were found among 11 of 12 pa-tients with CML, the mean of Ph~1 positive cells was 72.3%. The presenceof Ph~1 chromoso...

在12例慢性粒细胞白血病中，11例Ph~1染色体为阳性(阳性率平均为72.3％)，1例为Ph~1阴性；2例急性粒细胞白血病患者的骨髓中期分裂细胞具Ph~1染色体者分别占1/4及1/5，其中1例还发现微小体；1例继发性红细胞增生症患者，70％的骨髓中期分裂细胞为Ph~1染色体阳性，并发现染色体碎裂细胞。

On the basis of the concept that cigarette smoke creates a molecular field of injury throughout the respiratory tract, this study explores oncogenic pathway deregulation in cytologically normal proximal airway epithelial cells of smokers at risk for lung cancer.

这是一个在肺癌早期发现领域的关键性的敲门砖，因为目前还没有方法来辨识出那些在吸烟者中的占10-20%的会生肺癌的人，而美国的当前和以前的吸烟者有9000万人之多。总的来说，这些发现可能帮助解决巨大的且在不断增长的公共卫生方面的与肺癌有关的负担问题。

Results ① The percentage of positive TPOAb and TGAb were 91.4% and 74.4%, respectively in all the AIT patients. 47.6% of the patients had TSH levels within normal range (0.3～5mu/L).② All of the slides had different grades of lymphocytic infiltration. 49.3% had germinal center, 32.8% had Askanazy cells, 26.9% had plasma cells, 22.4% had colloid, and 9% had multinuclear giant cells.③ Lymphocytic infiltration was divided into four degrees. The levels of TSH and TPOAb increased significantly in the extremely heavy lymphocytic infiltration grade than in the others (P.05). There was no relationship between serologic markers and other cytopathologic features.

结果 ①82例患者中TPOAb、TGAb的阳性率分别为91.4%和74.4%，约有半数(47.6%)TSH值位于正常值范围内(0.3～5mu/L)；②所有患者细胞病理学均存在淋巴细胞不同程度的浸润，49.3%可见生发中心，32.8%可见嗜酸性变细胞，26.9%可见浆细胞，22.4%可见胶质，9%可见多核巨细胞；③将淋巴细胞浸润程度分级，分别与TSH、TPOAb及TGAb进行相关性分析，发现仅淋巴细胞极重度浸润者其血清TSH、TPOAb水平较其他组显著升高(P.05)，其他细胞病理学改变与血清学指标之间未发现显著相关性。

The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果：1合成的CS-PAA磁性聚合物微球呈球形，大小均一，TEM测定其干态下粒径为80nm左右，磁化曲线证实具有超顺磁性，具有一定的PH敏感性，固载表柔比星后，水溶液性状稳定，无沉淀物，DLS测定直径约200nm左右，测定载药率为15％，较文献报道高，包封率为20％。2肉眼观察试验组大鼠膀胱表面呈褐色，可见大量的Fe粒子聚集，普鲁士兰染色法显示，试验组大鼠膀胱壁内有大量的Fe粒子，分布至膀胱壁全层，与对照组大鼠相比，试验组大鼠的肝、脾内的Fe粒子聚集量明显降低；HPLC测定结果与Fe染色相同；高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高，其他组大鼠血生化指标没有明显变化。3MTT法发现，高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组，FCM发现试验药物组可引起明显的肿瘤细胞凋亡，试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C，试验组细胞Bcl-2蛋白减少，Bax蛋白变化不明显，Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P＜0.01)，其中高剂量组的抑制率最高。

From the early study of the pathogenesis of pre-eclampsia people have found its association with immunological function . In 1986 Ellis et al[1] had found that the extravillous chorionic cytotrophoblast contacting with the maternal tissue expressed high levels of Human leukocyte antigen-G, a major histocompatibility tissue-specific antigen . Extravillous chorionic cytotrophoblast with high levels expression of HLA-G proteins can invade the maternal deciduas and the maternal spiral arteries by displacing the endothelial lining and destroying most of the musculoelastic tissue of these arteries .

早期研究开始，许多学者即发现其与免疫学有密切关系，至1986年Ellis等[1]发现人类白细胞抗原(human leukocyte antigen，HLA) G分子高度表达在绒毛外滋养层细胞( extravillous cytotrophoblast，EVCT)上，即浸润至子宫蜕膜层甚至达子宫浅肌层以及子宫螺旋动脉内皮层，与母血及子宫组织直接接触的滋养细胞，这种独特的组织分布提示HLA-G分子在母胎免疫耐受方面起重要作用。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。