发现

Journal of Antimicrobial Chemotherapy Advance Access publication 6 December 2005 OXE β-lactamases in Acinetobacter:the story so far Molecular Chemotherapy,Centre for Infectious Diseases,University of Edinburgh,The Chancellor's Buliding,49 Little France Crecent,Edinburgh,EH16 4SB,UK The emergence of carbaoenem resistance in Acinetobacter baumannii has become a global concern since these β-lactams are often the only effectine treatment lsft against many multiresistant strains.A recent debelopmenth has the discovery of a novel group of narrow-spectrum OXA β-lactamases in carbapenem-resistant strains,some of whitch have acquired the ability to hydrolyse the carbapenems.The first of these was found in a strain isolated in Edinburgh before imipenem was in usr in the hospital.Whether these carbapenemases have been acquired or are part of the genetic make-up of this species has yet to be determined.More importantly,however,they represent an important stage in the evolution of antibiotic resistance in Acinetobacter.This paper discusses the emergence of these unusual enzymes over the past decade.

抗菌化学疗法》杂志上 2005年12月6日提前存取出版在不OXEβ-lactamases：到目前为止分子化疗，中心为传染性疾病，爱丁堡大学，议长，49岁的法国Crecent少、爱丁堡、EH16 4SB，英国 carbaoenem电阻的出现在鲍曼不动杆菌已成为全球关注这些β-lactams通常是唯一effectine对抗许多multiresistant菌株治疗lsft…最近的一debelopmenth已发现的一种β-lactamases仅OXA集团在carbapenem-resistant株，其中一些已经取得了hydrolyse能力的carbapenems第一个被发现在一株孤立在爱丁堡的药物有亚胺培南在使用之前在医院这些carbapenemases是否已经或正在部分的基因构成该物种还有待确定然而更重要的是，他们代表着一种重要阶段的抗生素耐药性的演化出不本文探讨了产生这些不寻常的酶在过去的十年。

It is well established that Cav1.2 encoded L-type calcium channel is prevailing component in cardiac system, while Cav1.3 encoded one dominant expressed in neuron and neuroendocrine cell. However, our and others' previous works have shown that Cav1.3 encoded LTCC was also found in the heart tissues, especially in pacemaking cells of sina atrial node, atrioventricular node and atrium.

最初人们认为心脏中的 L 型钙通道仅包括α1C（Cav1.2），但后来发现α1D（Cav1.3）在心脏中也有表达，并且优势表达于窦房结、房室结和心房，加之发现它在比较低的膜电位（－60~50mv）激活而且α1D基因敲除小鼠表现出窦性心动过缓和房室传导阻滞，所有这些都表明α1D 在维持正常的心脏节律中发挥着至关重要的作用。

Qingyang found an important precious fossils, Shocked by this strange discovery of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences research fellow human Dong, day and night from Beijing arrived in Qingyang and hardships, arrived at the three Shilipu.

庆阳发现了重要珍贵化石，惊闻这一奇特的发现，中科院古脊椎动物与古人类研究所研究员董枝明，日夜兼程从北京赶赴庆阳，来到了三十里铺。

The discovery of annual density bands of mass coral skeleton had a profound effect on coral paleoclimatology, and many patterns of density bands have been revealed throughout the global tropic ocean since then. At the first stage, people tended to explore the control factors of density changes from the environment where the coral grows, but they did not succeed. Since later part of 1980s, some researchers have focused on the skeletal architecture and integrated the signals of both environment condition and skeleton density bands to reveal the mechanism of skeleton density changes, and finally a model of skeleton growth was developed which can explain the almost existed patterns of skeleton density changes.

块状珊瑚骨骼密度条带年周期的发现对后来的珊瑚古气候研究产生了深远的影响，随后又发现世界各热带海域的珊瑚存在多种多样的骨骼密度变化模式，起先常从珊瑚的生长环境中寻找骨骼密度变化的控制因素，但是没有成功，从80年代后期，部分学者试图从珊瑚骨骼构架本身出发、综合考虑环境因素和骨骼密度条带之间的关系来探求骨骼密度变化的机理，并提出了一个可以解释大多数块状珊瑚骨骼密度条带变化模式的骨骼生长模型。

Only human and other mammals' remains were found, and no paleolithic tools were detected.

在该地点至今未发现石器，但发现了大量骨片。

A highlight of his career came in 2001 when the Paleontological Society recognized his achievements by awarding him the Harrell L.

他说："如果他们稍微动动脑子就会发现足够信息，他们在20世纪80年代就有可能获此发现。"

It may be the response of special sense cells on the maxillary palp for proteins

由于至今人们尚未在昆虫的味觉感受器中发现对蛋白质具有专一响应的感觉细胞，因此这一发现对深入研究其中机理是很有意义的。

Although the intact-receptor based biosensors of the maxillary palp of cockroach Periplaneta Americana are not yet practical analytical devices at present. Yet, sensitive and selective responses to biomolecules involving amino acids and protein, as well as some simple substance such as salts and sugars have been firstly obtained. It is already evident that receptor based biosensors are enormously superior to isolated receptor biosensors in terms of response time and recovery times, thus, the intact receptor biosensor worth of further investigation and development.

总而言之，本论文首次从电生理信号上对美洲蜚蠊下颚须的化学响应进行研究，初步探讨了基于美洲蜚蠊下颚须的整合受体生物传感器的特性；发现了美洲蜚蠊下颚须能够整合其密集的感觉毛阵列对化学刺激的响应；得到了蜚蠊对氨基酸和蛋白质等生物分子以及简单物质如盐和糖等的敏感而具有选择性的响应信号，并发现了糖和蛋白质的特殊响应信号；表明了美洲蜚蠊下颚须是一种新型整合受体生物传感器的敏感材料，进一步深入地研究信号波形及其整合原理、探寻糖和蛋白质的特殊受体细胞等，对这一类型整合受体传感器的研究发展是很有意义的。

in the inclusive physical education, the interactions of a cerebral palsied child and peers are varied under the influence of curriculum design. With different curriculum goals, contents, and ways of implementation, a cerebral palsied child and his or her peers have a different interaction. Besides, in our research, we especially detect that a cerebral child has more interaction with his or her peers during games or group activities.

五、在融合式适应体育教学中，脑性麻痹儿童与同侪的互动情况受到课程设计影响而呈现不同之互动情形：在不同的课程目标、内容以及实施方式下，研究发现脑性麻痹儿童与同侪间出现不同的互动情况，尤其在在游戏与团体活动中，研究发现脑性麻痹儿童与同侪间会出现较高之互动情况。

"Our findings document an abnormality of the neuroregulation of high-frequency heart rate variability, most likely indicative of parasympathetic nervous system activity, in members of a Naval Reserve construction battalion who became chronically ill during or shortly after service in the 1991 Gulf War," the authors write."Our findings, although unable to attribute specific symptoms of Gulf War veterans directly to early autonomic dysfunction, suggest possible links to be explored in future research."

研究人员指出，海军后备建筑大队的成员，在1991年波湾战争时或是结束后立即患病的成员中，我们的发现记载了高频心跳变异神经调控的异常，最可能代表副交感神经系统；我们的发现，虽然不足以将湾岸症候群特定的症状直接与早期自主神经失调相连，但是暗示这可能在之后的研究中进一步被厘清。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。