发明物

The invention provides the application of a B vitamin, a physiologically or pharmaceutically acceptable salt of the B vitamin, a hydrate of the B vitamin or a mixture of the B vitamin, the salt and the hydrate in the preparation of a composition for controlling body weight and blood sugar and/or moderating the insulin resistance.

本发明提供了B族维生素、其生理学上或药学上可接受的盐、其水合物或它们的混合物在制备控制体重、控制血糖和/或缓解胰岛素抵抗的组合物中的用途。

This invention provides a novel biocidal premixture, particularly useful as a component in cellulose reinforced thermoplastic composites.

本发明涉及一种新型生物杀灭剂预混合物，其特别可用作纤维素增强的热塑性复合物的组分。

The present invention is directed to substituted propylamine derivatives of formula I or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

本发明涉及式I的取代丙胺衍生物或其医药学上可接受的盐、含有这些衍生物的组合物、和其用于预防和治疗通过单胺再摄取改善的病状的使用方法，所述病状尤其包括血管舒缩症状、性功能障碍、胃肠道和泌尿生殖道病症、慢性疲劳综合症、纤维肌痛综合症、神经系统病症和其组合，特别是那些选自由严重抑郁症、血管舒缩症状、压力性和急迫性尿失禁、纤维肌痛、疼痛、糖尿病性神经病变和其组合组成的群组的病状。

The invention is concerned with novel and known pyrazole derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine.

本发明涉及新的和已知的吡唑衍生物、其制备方法、药物组合物及所述化合物在医学中的应用。

Specifically, the invention relates to vasoactive intestinal receptor binding peptides, derivatives and analogues of vasoactive intestinal peptide, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes.

具体地，本发明涉及到具血管活性肠受体结合特性的肽，血管活性肠肽的衍生物和类似物，和用放射性同位素标记这类肽的实施方案，以及生产、放射性标记与使用这类肽的方法和药盒进行放射性诊断和放射性治疗。

The obtained terephthalaldhydic acid semicarbazone has such advantages as simple process and high purity (above 99% after post treatment), and can be used as standard in enzymoimmunoassay of semicarbazide.

本发明成功合成了呋喃西林代谢物氨基脲的衍生物氨基脲缩对醛基苯甲酸，合成步骤简洁，经过后处理，纯度高达99％以上，完全可以用作标准品，为以后人们对氨基脲的酶联免疫检测研究提供了方便的途径，可以满足国内对其研究的需要。

The instrument may be used in measuring sheat wave resonant absorption spectrum of liquid film in 1x10 to the power -5 -500 Hz frequency range and in providing measurement data for the research of the interaction range between clusters, long chains and multibands of liquid film, the group behavior of molecules and clusters, the long chain in polymer solution, the second, the third and the fourth group behavior in left liquid and other group behavior in chemical solution and complex.

本发明的谱仪可在10 －5 ―500Hz频率范围内，测量液体膜的切变波共振吸收谱，为研究溶液中的团簇间、长链间和多键间的交互作用范围，分子和团簇的集团行为，高分子溶液中的长链，生命液体中的二、三、四级或其他化学溶液和络合物中的基团的行为提供可靠的测量。

The present invention concerns a compound having the formula a N-oxide form, a stereochemical isomer, racemic mixture, salt prodrug, ester or metabolite thereof.

本发明涉及具有式的化合物、其N-氧化物形式、立体化学异构体、外消旋混合物、盐、前体药物、酯或代谢物。

The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9-; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is -C-,-O-C-,-NR8-C-,-O-C1-6alkanediyl-C-,-NR8-C1-6alkanediyl-C-,-S2-,-O-S2-,-NR8-S2 ; R3 is C1-6alkyl, aryl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, or arylC1-4alkyl; R4 is H, C1-4alkylOC, carboxyl, aminoC, mono- or di(C1-4alkyl)aminoC, C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted C1-6alkyl; R5 and R6 are H or C1-6alkyl.

本发明涉及右式化合物其N-氧化物、盐、立体异构形式、外消旋混合物、前药、酯及代谢物，其中R 1 及R 8 各是氢、C 1-6 烷基、C 2-6 烯基、C 3-7 环烷基、芳基、Het 1 、Het 2 ；R 1 也可以是式(R 11a R 11b )NC(R 10A R 10b )CR 9 -之基；t是0、1或2；R 2 是氢或C 1-6 烷基；L是-C-、-O-C-、-NR 8 -C-、-O-C 1-6 烷二基-C-、-NR 8 -C 1-6 烷二基-C-、-S 2 -，-O-S 2 -、-NR 8 -S 2 -；R 3 是C 1-6 烷基、芳基、C 3-7 环烷基、C 3-7 环烷基C 1-4 烷基或芳基C 1-4 烷基；R 4 是氢、C 1-4 烷基OC、羧基、氨基C、一-或二(C 1-4 烷基)氨基C、C 3-7 环烷基、C 2-6 烯基、C 2-6 炔基或任选被取代的C 1-6 烷基；R 5 及R 6 是氢或C 1-6 烷基。

The enzyme tannase, which is used in the present invention, is known to hydrolyse the galloyl ester linkages of polyphenolic substrate s such as tannic acid, tea polyphenol gallates, and the like.

我们知道，这种在本发明中所使用的丹宁酶，可水解多酚酸类物质的棓酸酯键，如丹宁酸，茶叶的棓酸多酚酯及其类似物。

In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是，在否定句或疑问句里，这种带有"do"的方法表达的效果却没有什么强调的意思。

Go down on one's knees;kneel down

屈膝跪下。。。下跪祈祷