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Ultimately, vulnerable groups of neurons atrophy and die in a process that may involve excitotoxicity (overstimulation of neurotransmitter receptors on neuronal surface membranes), collapse of calcium homeostasis, inflammation, and depletion of energy and growth factors. A form of apolipoprotein E, apoE4, contributes to the abnormal accumulation of A and tau, but probably also damages mitochondria and the cellular cytoskeleton. A , tau, apoE and -synuclein interact with many other molecules and modulate diverse signalling cascades that regulate neuronal activity and survival.

最后,易感神经元会萎缩直至死亡,原因可能有兴奋性中毒(神经递质对神经元表面受体的过度刺激引起),钙稳态失衡,炎症反应,能量和生长因子的耗尽。apoE4的产生可导致A肽和tau蛋白的异常聚合,可能也损害线粒体和细胞骨架。A肽、tau蛋白、apoE和突触核蛋白可与很多分子反应,也可调节不同信号级联反应,这些级联反应对于维持神经元活动性和生存性意义重大。

Sources have it that the incidence rate of intracranial gliomas postoperative reactional enhancement is 65.7%(134/204), whereas that of tumor residual is 34.3%(70/204) [1]. The network is capable of learning and memorizing, and can memorize the data diffusion features. Therefore, if data with such rates are employed to train the network, it will overstudy reactional enhancement. Even though the network training is not successful and all are diagnosed as reactional enhancement, the correctness will be still as high as 65.7%.

据文献报道,胶质瘤术后反应性强化的发生率是65.7%(134/204),肿瘤残存发生率是34.3%(70/204)[1],因为网络具有学习和记忆功能,能够记住数据的分布特点,因此用此比率的数据训练网络,对反应性强化会过度学习,即使网络训练不成功,全部诊断为反应性强化,正确率仍然高达65.7%。

S short half-life and immunological reaction. To overcome these drawback of protein injection, we choose the gene transfection method to inhibit the overexpression of VEGF in the pannus and observe the inhibition effect of the formation of pannus during the development of rheumatoid arthritis.

为了克服生物制剂关节腔注射疗法半衰期短,局部反应大的缺点,我们采用滑膜组织基因转染的方法,将表达反义VEGF基因的腺病毒载体导入病变的滑膜组织,在基因水平上千预病变滑膜的VEGF过度表达,并探讨其对RA形成的影响。

It is currently accepted that corneal graft rejective reaction is a complicate reaction course which is led by T lymphocyte,the over-activation of cytokine and adherence factor participate corneal graft rejective reaction.

目前研究表明,角膜移植排斥反应是一个T淋巴细胞主导参与的复杂的反应过程,受多种因素的调节,许多细胞因子、粘附因子的过度活化参与角膜移植排斥反应。

Mama explains the concept of the bad apples in every barrel, literally. A funny looking apple is fine on the inside, but a perfect looking apple is bad on the inside. Finally, the attraction of a toy almost causes usually cautious Brother to go for a ride with a stranger. Sister isn't tattling when she tells her parents, she's just concerned for Brother's safety. The bears' rules are listed on the last page, including one about the privacy of a bear's body, a topic not discussed in the text.

熊妹妹听了爸爸的话之后,又看到了关于失踪小熊的新闻报道,从这之后,她就开始反应过度强烈,她把每个陌生人都当作了坏人……平时一直小心谨慎的熊哥哥被一个陌生人拿的玩具深深吸引了,他就不自觉地跟着这个人走了好远,熊妹妹非常担心哥哥的安危,她告诉了父母……在本书的最后几页,贝贝熊父母还列出了一些儿童安全常识,告诉孩子如何面对陌生人,如何辨别他们的行为举止。

But there are limited roles for the information transmission effect of stock index future in stabilizing the spot market. This limitation comes from the followings: First, stock index future has a finite function of discovering price; Second, it is possible that stock index future transmits information with noise to the spot market; Third, the extent of the ways of explaining information affect to stabilizing the mark et; Forth, stock index future may bring about homogeneous information, make the market lose heterogeneous briefs, which may bring about frequent overacting.

但是,股指期货信息传递效应对现货市场的稳定作用具有一定的局限性,这种局限性源于:第一,股指期货有限的价格发现功能;第二,股指期货有可能向现货市场传递有噪音信息;第三,市场解释信息方式影响稳定作用发挥的程度;第四,股指期货引起信息同质性,使市场丧失信念多样性,更易反应过度。

The child overreacts and/orunderreacts to sounds to an extremely marked degree, regardless of thetype of sound.

对于任何声音,孩子出现程度严重的过度反应和过低反应。

The low threshold dog reacts to nearly everything and often overreacts.

低阈值的犬差不多对一切作出反应,通常还是过度反应。

Think of allergies as the body's way of fighting unwanted guests. The trouble starts when allergens, such as pollen, certain foods, or animal dander invade the mucous membranes of the eyes and throat, this triggers the body's antibodies to fight the invaders, causing a release of histamines. The body's reaction to the allergens is often excessive, leading to sneezing, shortness of breath or itching. It's these reactions that wear you down, especially when they keep you from sleeping.

过敏反应其实是机体抵抗外来客的一种反应方式,当过敏原如花粉、某些食物或动物皮屑等通过眼睛和喉咙的粘膜入侵机体时,机体就会产生抗体释放组织胺来抵御入侵者,这种反应常常过度从而导致出现打喷嚏、瘙痒甚至气急等症状的发生,这些反应症状会使你感到疲劳、特别会导致睡眠不好。

Re: the school incident, clearly the school overreacted, at least in terms of the Principal's wording (typically if you wear clothes that cause a disturbance you get sent home or turn your shirt inside out), but clearly the kids were also obviously doing it as a (perhaps playful, but I doubt it) f**k you to the Mexicans at their school.

回复:学校的事件,很明显,学校反应过度,至少在校长的措辞(条款通常如果你穿的衣服,导致你送回家或把你的内而外衬衫干扰),但很明显,孩子们,也明显做作为一个f ** k您的墨西哥人在他们的学校。

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However, as the name(read-only memory)implies, CD disks cannot be written onorchanged in any way.

然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

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A single payment file can be uploaded from an ERP system to effect all pan-China RMB payments and overseas payments in all currencies.

付款指令文件可从您的 ERP 系统上传到我们的电子银行系统来只是国内及对海外各种币种付款。