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The favorable regions for DNA cleavage were observed to be pH 3.6-5.6 and pH 9.0-10, suggesting that the species responsible for DNA cleavage are different in different pH regionsOur results do not support a widely accepted conclusion that the copper-bound or free hydroxyl radicals provided by CuZnSOD with its end product hydrogen peroxide lead to release of copper from its host, the Fenton reaction between the free copper and the hydrogen peroxide being responsible for the aberrant copper-mediated oxidation chemistry in CuZnSOD.

目前广泛接受的一个推测机理是CuZnSOD与H_2O_2反应生成羟自由基损伤酶自身导致Cu释放,而释放出的游离Cu进一步与H_2O_2发生Fenton反应导致了异常催化氧化反应的发生。

We find that the impulse responses of output growth to financial intermediation shock are similar in the patterns among the observed countries. However, the responses are different in the strength across the four countries. The result mentioned above is consistent with Lehr and Wang(2000). Especially, the responses of output growth about Japan and Taiwan in strength are greater than that about Korea and Singapore.

面对金融中介冲击,本文发现各国产出成长之反应在型态上大致相似,然而反应强度却有颇大差异,与Lehr and Wang(2000)的结论是一致的,特别是日本与台湾在产出成长反应的强度大於韩国与新加坡。

And in this resin most of the phenol was free, that was to say it didn't co-condense with UF species, MF species, and even formaldehyde. So the method to add phenol to MUF resin in the end of the preparation of MUF resin couldn't guarantee the co-condensation between MUF resin and phenol to come forth.

另外,几乎所有的苯酚在树脂中也都处于游离状态,它既未与UF树脂或MF树脂发生反应,也未与游离甲醛发生反应,因此,在树脂合成后期向树脂中加入苯酚的方法不能保证共缩聚反应的发生。

However, inhibiting rates of Ly-CL by sodium benzoate and mannitol were higher than IR of PMN-CL and IR of Ly-CL by supcroxide dis mutase and catalase were lower than IR of PMN-CL.

氧自由基清除剂作用于PMN—CL和LY—CL反应的结果表明,L—组氨酸均明显抑制PMN—CL和LY—CL反应;苯甲酸钠和甘露醇抑制LY—CL反应的抑制率明显高于PMN—CL;而超氧化物歧化酶和过氧化氢酶抑制LY—CL的IR明显低于PMN—CL。

Analysis of nuclear extracts of human cells has indicated a similar excision repair mechanism for nick-directed mismatch correction in higher cells, and several reconstituted systems that rely on purified human proteins have been described, such as hMutSα、hMutSβ、hMutLα. Recently, scientists discovered that nickel could be inhibitors of DNA repair. Nickel can greatly enhance the mutagenicity and genotoxicity of compounds in cigarette by inhibiting the nucleotide excision repair pathway in human cells. We have confirmed that nickel could inhibit MMR of E. coli and human and presumed that nickel inhibited repair before MutH incision of the MMR in E. coli. However, there is no evidence of mechanism of nickel inhibiting MMR in human cells.

镍是存在於香菸中的微量金属,近年来有学者发现镍是DNA修复反应的抑制剂,长期抽烟的人会容易因为香菸中化合物攻击DNA而引起突变,进而引起肺癌,而镍会抑制核苷酸移除修复系统(nucleotide excision repair;NER),所以使得体内的DNA损伤无法修复;过去实验室已经证实大肠杆菌的核酸配对错误修复系统会受到镍等重金属的抑制,并且推测出镍的抑制反应是抑制在修复反应的上游nicking的步骤;另外,也证实了人类的核酸配对错误修复系统也会受到镍的抑制,然而还没研究证实会抑制在核酸配对错误修复反应的哪个步骤。

Modifications of alkylation, chlorination and Vilsmeier reaction were employed for the synthesis of aromatic aldehydes bearing nitrogen mustard derivatives and halogenoalkylpiperazinyl.

通过对Vilsmeier反应、烷基化反应和氯化反应的改进提出了以简单易得的苯胺和苯基哌嗪为原料制备氮芥和哌嗪芳香醛的方法。

Finally, pentyl acetate and benteine could be respectively synthesized by esterification reaction in the presence of nanometer rare earth composite solid superacids (SO_4)~(2-)/ZrO_2-Gd_2O_3 and (SO_4)~(2-)/ZrO_2-Nd_2O_3. The effects of reaction time, reaction temperature, the mol ratio of acid to alcohol and the use level of catalyst on esterification yield were discussed. In the end, we obtained their optimal reaction conditions.

采用纳米稀土复合固体超强酸SO_4~(2-)/ZrO_2-Gd_2O_3,SO_4~(2-),~/ZrO_2-Nd_2O_3分别合成了乙酸戊酯和乙酸苄酯两种香料,实验考察了反应时间、反应温度、醇酸比及催化剂的用量对酯化率的影响,并由此得出反应的最佳条件。

The response to single compound: To both females and males, the compounds that elicit larger responses of adults are benzaldehyde, benzene acetaldehyde, hexanol,β-phenyl ethyl alcohol, benzyl alcohol, cyclohexanol and eugenol. Phytol, 2-methyl-cyclohexanone and β-caryophyllene reveal to have weaker activity.

对单一化合物的反应:两种昆虫,不论是雌蛾还是雄蛾,能引起较强EAG反应的化合物均为苯甲醛、苯乙醛、正己醇、β-苯乙醇、苯甲醇、环己醇和丁香酚,植醇、2-甲基环己烷和β-石竹烯仅能引起微弱的EAG反应。

The solvent effects were studied with the conductor-like polarizable continuum model respectively in the solvents acetonitrile and water, and we found that the solvent effects reduce the activation energy, but the reduction is small, these reactions are not sensitive to the solvent polarity.

采用导电极化连续介质模型分别研究了在乙腈与水溶液中反应的溶剂化效应,发现这些溶剂可降低反应的活化能,但降低的程度比较小,反应速率变化不大。

A series of chemical reactions in which the product of one is a reactant in the next.

一系列的化学反应,其中某次反应的产物是下一次反应的反应物。

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She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了,但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场,你等着挨绳子吧!

Several theories about reigniting and extinguishing of the arc have been refered.

本文综合考虑了几种电弧重燃和熄灭理论。