反应体

Hydroxysteroid dehydrogenase/carbonyl reductase ( 3α-HSD/CR,EC 1.1.1.50 ) from Comamonas testosteroni is an inducible enzyme which catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH. 3α-HSD/CR was a member of the SDRs family, whose crystal structure had been solved by X-ray diffraction in 2000. The structure of 3α-HSD/CR is a homodimer which shows a typical pattern of Rossmann-fold structure consisting of βαβ units, and reaveals similarity with other members upon the SDRs family.

中文摘要 3α-Hydroxysteroid dehydrogenase/carbonyl reductase ( 3α-HSD/CR，EC 1.1.1.50 )是从Comamonas testosteroni菌体中分离而来的诱发性酵素，利用NAD+为辅因子，将受质androsterone氧化成androstanedione并伴随NADH的生成而完成催化反应。3α-HSD/CR是属於SDRs家族成员之一，其立体结构已经在2000年利用X-ray晶体绕射所解出。3α-HSD/CR在结构上为一同源双聚体，并和其它家族成员一样具有βαβ二级结构所叠合组成的Rossmann-fold特徵。

Three chiral phosphorus ligands were prepared using anisole as the startingat material.Their applications in the asymmetric hydroformylation and asymmetric conjug ed addition of diethylzinc to enones were investigated.

以苯甲醚为原料，合成了三种新的手性含磷配体，考察了三种配体在不对称氢甲酰化反应和ZnEt2对环己烯酮的不对称共轭加成反应中的应用。

Based on the addition of vinyl magnesium bromide to the chiral non-racemic synthon 2 derived from-1, an enantioselective total synthesis of-3, the antipode of marine alkaloid halitulin 10 steps, overall yield: 5.3% from (R-1 was achieved using aza-Claisen rearrangement as a key step.

取得的主要结果如下：一、从-苯基甘氨醇1出发，通过已知的哌啶手性合成砌块2的加成反应，建立了经aza-Claisen重排反应进行海洋生物碱halitulin手性分子片断的对映体--isohaliclorensin 3不对称合成的路线。

Based on the addition of vinyl magnesium bromide to the chiral non-racemic synthon 2 derived from-1, an enantioselective total synthesis of-3, the antipode of marine alkaloid halitulin 10 steps, overall yield: 5.3% from (R-1 was achieved using aza-Claisen...

取得的主要结果如下：一、从-苯基甘氨醇1出发，通过已知的哌啶手性合成砌块2的加成反应，建立了经aza-Claisen重排反应进行海洋生物碱halitulin手性分子片断的对映体--isohaliclorensin 3不对称合成的路线。

Objective: The signs and symptoms of ankylosing spondylitis respond inadequately to nonsteroidal antiinflammatory drugs, corticosteroids, and disease modifying antirheumatic drugs in quite a number of patients.

目的：许多强直性脊柱炎患者的症状和体征对非甾体类抗炎药物、皮质类固醇、缓解病情抗风湿药物的治疗反应不佳。

There is up-regulation of striatum D2 receptors in lesioned side in experimental hemi-parkinsonism which show good correlation with rotation behavior induced by Apomorphine, and coincided with the pathological findings.

大鼠偏侧PD模型患侧纹状体D2受体出现上调反应，这种上调反应与APO诱导的行为学改变呈良好的相关性，与病理组织学改变相符合。

The reaction-diffusion model was developed to analyze the concentration of enantiomers and the separation factor of the enantioseparation process of chiral emulsion liquid membrane by studying the principle and some factors of mass transfer process. The mass transfer resistance of boundary layer in outer aqueous phase and the interfacial chemical reactions at the liquid membrane interfaces were taken into account in the model equations.

通过对乳状液膜手性分离过程中传质机理的研究以及各影响因素的分析，得到了可以分析和预测乳状液膜手性拆分过程传质的反应-扩散模型，该模型同时考虑了外水相边界层的扩散阻力和手性对映体与载体的反应阻力。

The C〓-symmetric chiral bisoxazoline derivatives have recently been employed as ligands in a wide variety of metal-catalyzed asymmetric reactions.

在最近十几年中，具有C〓对称性的手性双噁唑啉作为配体被广泛应用于各种金属催化的不对称合成反应，并获得了良好的立体选择性，在某些反应过程中已表现出近似化学酶的功能。

Secondly, 11 chiral ligands containing BINOL and its derivatives werescreened in the asymmetric HDA reaction between Brassard diene withbenzaldehyde. The results revealed that-BINOL shows higherenantioselectivity and reactivity than the others.

其次将 11 个二齿配体 BINOL 及其衍生物用于 Brassard 二烯与苯甲醛的不对称 Hetero-Diels-Alder 反应，结果表明，-BINOL 表现出相对较好-i-范谦四川大学博士论文的反应活性和对映选择性。

The pathological changes in the bronchia and lung of the 111WLM and the 174 WLM groups were characterized by the chronic inflammation.

发现大鼠吸氧及子体吸入对大鼠靶器官的损伤效应中文摘要入氧及子体后BALF细胞工L一6 mRNA的表达在174WLM剂量组明显增高，而PBMC工L一6 mRNA的表达在66WLM和174WLM剂量组都有显著增高，表明PBMC可作为早期反应的靶细胞。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐