反应体

Further investigation will potentially provide the practical technologies for the diagnosis of human acrosome reaction deficiency

孕酮具有促进人精子受透明带诱导顶体反应的作用；小鼠透明带溶解液具有诱导人精子产生顶体反应的效果并确定了mZPS诱导人精子顶体反应的量效关系，为建立人顶体反应缺陷症的实用诊断技术提供基础。

The structure of MCM-41 material is different from that of ordinary microporous zeolite molecular sieve, so is that of amorphous aluminosilicate.

发现在不同反应体系里，不同合成条件下，中孔MCM-41分子筛的形成机理不完全相同。

Armed with asecurity tank and some ammo, your goal is to break into the complex and hack through the enemy-filled base to resume control of the world's security, finances and communications.

装备安全坦克和某个弹药，你的目标乃是闯进建筑群，通过敌人控制的世界。摧毁不同的反应体完成你的任务。

The main research work and its results are: 1Empirical results are analysed for the relations of fault displacement and earthquake magnitude, and difference between permanent ground deformation and maxium dynamic relative displacement on the two sides of fault; 2An analytic method is proposed for resopnse of a buried pipeline due to earthquake fault movement; 3A new shell model with an equivalent boundary and relted finite element analysis method are proposed for estimating response of a buried pipeline under large fault movement; 4By the proposed method, damage performance of water supply steel pipelines with large diameter is simulated to the real cases in Kocaeli Earthquake and Ji-Ji Earthquake, and simulating results show the real failure mode of pipes is revealed; 5Effects of overlying soil and soft/hard interlayers are analyzed on ground rupture mode and degree due to earthquake fault, and some earthquake rupture phenomena in soil layers are theoretically described for the first time; 6Pipeline response characters are discussed for the case of considering effects of soil layers on ground rupture mode; 7Research results and proposed method are applied in seismic analysis of pipline acrossing fault in the Gas Tansportation Project from West to East in China.

主要工作和成果包括：1）分析了不同断层位错形式下地表破裂位错量与震级之间的经验关系，并基于集集地震近断层记录分析了断层两侧永久地面变形和地震动相对位移幅值之间的差别，为合理地考虑地震断层位错地面变形动态影响提供了依据；2）发展了断层位错地面大变形下管线反应分析模型并给出物理概念明确、简单实用的解析分析方法；3）建立了断层位错下埋地管线反应分析的等效边界壳模型有限元方法，方法中引入了以非线性弹簧形式模拟离断层较远处管段影响的等效边界，简化了计算模型并突出了近断层处管体反应；4）利用等效边界壳模型方法，对土耳其地震和集集地震中大口径埋地管线震害进行了模拟，结果表明所提方法可以更清地解释震害所表现的管体破坏特征；5）研究了覆盖土层和软硬夹层的存在对断层位错地面破裂形式和程度的影响，首次从理论上解释了某些地震地表破裂现象；6）探讨了考虑土层对断层位错地面变形影响的管体反应特征；7）本项目成果已在西气东输工程的管道跨断层抗震问题分析中得到了应用。

Some approved aneugens Trip terygiuwlIypogaucum (evelHutch, colchicine, thiabendazole, a tropine sulfate,d-ubocurarine was added into the reactive system respectively and the changes of their absorption values were taken down during different periods under the conditions of 37 0C and 350nm .

本研究通过多步聚合和解聚合反应从猪脑中分离纯化微管蛋白，建立微管蛋白的体外聚合和解聚合反应平衡体系，并将已证实的非整倍体诱发剂（昆明山海棠根部水抽提物、2-（4′-噻唑）苯丙咪唑、硫酸阿托品、d-筒箭毒碱）分别加入此反应平衡体系中，于37℃、350nm条件下，记录此体系不同时期的吸光值变化，与阳性对照物和溶剂对照处理平衡体系后的吸光值在相同时间点作比较，以此评估这几类非整倍体诱发剂对离体条件下的微管蛋白聚合的影响，寻求这几类非整倍体诱发剂是否可通过抑制微管蛋白聚合作用途径而诱发非整倍体。

A dye recycled photosensitization system has been designed. As a result of studies in the mechanism of electron transfer reaction of xanthene iodonium salt, it is proposed that the dye-recycled process consists of three-step reactions during the photosensitization: The oxidative fading product of dye is formed through electron transfer under irradiation; In the presence of H-donor, product changes into acidic leuco dye product; Product undergoes deprotonization under action of base to regenerate initial dye.

本文设计了染料循环再生的光敏反应体系，通过对占吨碘翁盐电子反应机制的深入研究，提出了占吨染料在光敏反应过程中的染料再生循环，它依次由三个反应过程组成：在光作用下，通过电子转移反应，产生染料氧化褪色体；在H给体存在下，通过H转移反应，使产物转化为染料酸式隐色体；在碱作用下，发生去质子反应，染料再生回复到染料的起始结构。

In this thesis,the AM1,MNDO,MINDO/3(mainly AM1)and INDO/S-CI semiempirical MO methods were used toinvestigate the excited-state intramolecular protontransfer reactions of salicylic acid derivatives—salicylic acid,methyl salicylate,salicylaldehyde,o-hydroxyaceto-phenone,salicylamide and 3-hydroxy-picolinamide (6 conformers and 2-3 anion species);2-(2'-hydroxy-5' methylphenyl) benzotriazole(4 conformers),2-(2' hydroxyphenyl) benzimidazole (3 conformers and 3anion species),Bis-2,5-(2-benzoxazolyl)hydroquinone(3 conformers),2-(2'-hydroxyphenyl)benzothiazole(2conformers) and 7-azaindole dimer (2 conformers).Theinvestigations were described as follows.Geometry optimization,relative stability andhydrogen bonding energy First,for sylicylic acid derivative molecules,the AM1,MNDO and MINDO/3 methods were used toinvestigate ground-state geometry optimization,energies,relative stabilities and hydrogen-bondingenergies on the five kinds of the molecules(designing 6 conformers and 2-3 anion species).Comparing with experimental data,the optimizedgeometry,the order of stability,the hydrogen-bonding energies and the distances between O-O in O-H..O hydrogen bonds by AM1 method were in agreementwith the experimental data,however,the C-C bondlengths optimized by MNDO and MINDO/3 were longer,C-O and O-H bond lengths were shorter;for C-N bondlengths,the results opitimized by MNDO method werethe same as those by AM1 method,nevertheless the C-Nbond lengths given by MINDO/3 method were muchshorter.For some sylicylic acid derivatives(e.g.methyl salicylate,salicylamide),the order ofstabilities on the conformers given by MNDO andMINDO/3 methods were not in agreement with theexisting conformers deduced by experimental methods,and the hydrogen bonding energies calculated by MNDO.and MINDO/3 methods were smaller.Second,the studyon the other systems found that the optimizedgeometry of the proton-transfered product with INDOmethod could not be obtained,only could theoptimized geometry of reactant be obtained,and thecalculated hydrogen bonding energies were greater.Many results of calculation indicated that the studyon the excited-state intramolecular proton transferreaction system using AM1 method was suitable andreliable.

本论文用AM1、MNDO、MINDO/3（主要是AM1）和INDO/S-CI半经验分子轨道方法对水杨酸衍生物系列——水杨酸、水杨酸甲酯、水杨醛、O-羟基乙酰苯酮、水杨酰胺和3-羟基吡啶酰胺（6种异构体和2-3种阴离子）；2-（2'-羟基-5'-甲基苯基）苯并三〓唑（4种异构体）；2-（2'-羟基苯基）苯并咪唑（3种异构体和3种阴离子）；2，5-二间氮杂氧茚氢醌（3种异构体）；2-（2'-羟基苯基）间〓杂硫茚（2种异构体）和7-〓吲哚二体（2种异构体）的激发态分子内质子转移反应在以下几个方面进行了较系统的理论研究：几何构型优化和相对稳定性及氢键能首先以水杨酸衍生物系列分子为例，用AM1、MNDO和MINDO/3方法考察了5种分子（每种分子设计6种异构体和2-3种阴离子）的基态几何构型优化，能量、相对稳定性和氢键能计算，通过和实验数据进行比较，AM1方法给出的优化几何构型、稳定性次序、氢键能和O—H。。。O氢键的0—0距离与实验数据吻合最好，MNDO和MINDO/3方法优化的C-C键长偏长，C-O键和O-H键长偏短；对于C-N键长，MNDO和AM1优化结果差别不大，而MINDO/3给出了过短的C-N键长，MNDO和MINDO/3方法给出的有些水杨酸衍生物分子（如水杨酸甲酯和水杨酰胺）异构体的稳定性次序和实验上推测的可存在异构体结果不一致，MNDO和MINDO/3方法给出的氢键能偏低，对其他体系的研究发现INDO方法常常不能得到质子转移产物的优化几何构型，只能得到反应物的优化构型，并且估算的氢键能偏高，大量的计算结果表明AM1方法对本论文研究的激发态分子内质子转移反应体系是适宜和可靠的。

The third part of this thesis is reactive simulating calculation In this section, some well-known auxiliaries are selected to compute in density functional theory B3LYP on Gaussian 03, from which the relationship between reaction active energies of transition states and enantiomeric excess of chiral products homoallylic alcohols isobtained based on relative reactive ratio theory. Using this relationship, calculations on the reaction of more than eight auxiliaries with four other aldehydes are carried out in AMI and MNDO, proving that N,N\'-dibenzyl tartamide has higher enantioselectivity than others in this reaction.

第三部分为计算化学部分，运用密度泛函理论B3LYP方法在Gaussian03软件上对已经报道的几种手性配体参与的醛不对称烯丙基化反应过程进行模拟计算，基于相对反应速率理论找出两种构型过渡态间活化能的差异与产物光学收率之间的关系；并以此为基础，用AM1和MNDO方法对上述合成的几种配体控制的反应过程进行量化计算，从而在理论上证实了N-苄基酒石酸二酰胺配体在醛的不对称烯丙基化反应中具有较高的立体选择性。

This work, concentrated on the asymmetric allylation of aldehydes controlled by different chiral auxiliaries prepared from rotational pure tartaric acid, can be divided into three parts.The first part aims to review the developments of chiral drugs and asymmetric synthesis, from which derived the present research topic backgrounds and works.Synthesis and applications of allylation from aldehydes are the second part of the thesis. By optimizing the reaction conditions, such as solvents, temperature, time and chiral auxiliaries like N,N\'-dibenzyl tartamide, N,N\'-p-dimethylphenyl tartamide, N,N\'-o-dimethylphenyl tartamide, N,N\'-o-dichlorophenyl tartamide, N,N\'-a-dinaphyl tartamide, N,N\'-dicyclohexyl tartamide and N,N\'-diphenyl tartamide, ideal experimenttal conditions are obtained according to HPLC monitoring, as well as the auxiliaries\' recoveries experiments. Starting from benzaldehyde and 3-bromopropaldehyde, N,N\'-dibenzyl tartamide is considered the best auxiliary in this reaction.

本文介绍了醛的不对称烯丙基化反应，以光学纯酒石酸为原料，研究了不同构型手性配体在醛的烯丙基化反应中的立体选择性，全文共分三部分十个章节：第一部分对当前手性药物和手性技术进行了概述，并由此展开了本文的研究背景和任务；第二部分为有机合成部分，对醛的不对称烯丙基化反应进行了深入探讨，以苯甲醛为原料对反应条件进行优化，在优化的反应条件下对制备的七种可回收手性酰胺配体(N-苄基酒石酸二酰胺、N-对甲苯基酒石酸二酰胺、N-邻甲苯基酒石酸二酰胺、N-邻氯苯基酒石酸二酰胺、N-a-萘基酒石酸二酰胺、N-环己基酒石酸二酰胺和N-苯基酒石酸二酰胺)进行筛选，优化配体回收实验条件，最终确定出N-苄基酒石酸二酰胺在苯甲醛的不对称烯丙基化反应中具有较大优越性，结晶回收的手性配体光学纯度保持不变。

The different factors involved in the process of the folding and activation of the microbial lipase are reviewed in this article,including lipase-specific foldase,lipase activation factor,prosequence,calcium ion and disulphide bond.

对微生物脂肪酶活性构像的形成和激活机制进行深入研究，有助于我们更好地了解脂肪酶的结构和功能，为脂肪酶基因的大量表达和体外定向进化奠定基础。本文主要综述了作为脂肪酶结构成分的多种因子在脂肪酶活性构像形成、激活及稳定中的作用。具体催化反应体

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。