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双胞胎

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Dizygotic twins, like any other siblings, have an extremely small chance of having the exact same chromosome profile.

严谨地讲,因为是不同胎盘而是认为是异卵双胞胎,这个论断已经靠不住了,因为如下文所示,有20-30%的可能性同卵双胞胎有独立的胎盘。

Dizygotic twin pregnancies account for about two-thirds to three-quarters of all spontaneous multiple pregnancies in a random population, therefore the results of this study predominantly, but not exclusively, represent fraternal twins.

因为在随机人群的自发性多胎妊娠中,双合子双胞胎妊娠占了大约2/3到3/4,所以本研究主要反映了异卵双胞胎的情况。

While the effect of IGF on the ovaries likely involves fraternal, or dizygotic, twins, they were not distinguished from identical, or monozygotic, pregnancies in this study.

在本研究中,虽然IGF作用于卵巢可以引起异卵或双合子双胞胎妊娠,但是这种妊娠不能和同卵或单合子双胞胎妊娠相区别。

I have a twin elder sister, possible because is the twin, I and the elder sister put on the same clothes since childhood, moreover long resembling, always receives very many human of attention, always feels extremely embarrassedly.

我有一个双胞胎姐姐,可能因为是双胞胎,/,我和姐姐从小穿同样的衣服,,而且长的相象,总是受到很多人的关注,,总是感到非常不好意思。。

Misfortune of the twins, the twins that were misfortunate, had a mighty magical power therefore they had a long life, misfortune was born misfortune

双胞胎的不幸,不幸的双胞胎,有着极强的魔力,因而也有着很长的寿命,不幸又带来不幸

This is the first report for RA that examines gene expression patterns in monozygotic twins.

双胞胎体内这三种基因表现形势的差异导致双胞胎中只有一个会得风湿病。

Studies of monozygotic twins suggest a 70% chance of a twin developing psoriasis if the other twin has psoriasis.

同卵双胞胎的研究表明了一个双发展中国家70%的机会银屑病如果其他双胞胎银屑病。

Studies of monozygotic twins suggest a 70% chance of a twin developing psoriasis if the other twin has psoriasis.

同卵双胞胎的研究表明了一个双发展中国家70%的机会牛皮癣如果其他双胞胎牛皮癣。

Scientists compared gene expression patterns of 11 pairs of monozygotic twins, who shared the same egg and were genetically identical, but only one of them had RA.

科学家对11对单卵双胞胎的基因表现方式进行了对比,这些双胞胎共享着同一个卵子,具有同样的遗传。他们中只有一个患有风湿病。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病,不管是急性淋巴性白血病或是急性骨髓性白血病,在染色体11q23部位有染色体易位的情况;这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是,单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%;并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且,这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后,而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖,遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以,白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

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然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

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