双烯合成

Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我们以水杨酰胺为起始原料，经Reformatsky反应、烷基化、Diekmann环合、烯醇化、酯化等反应合成双环母核2；再从L-羟基脯氨酸出发，经酯化保护羧基、保护氨基、保护羟基、硼氢化还原酯得醇、Sn2取代和Mitsumobu反应等合成巯基侧链3；最后由化合物3经脱保护、水解得硫醇，和化合物2在二异丙基乙基胺的作用下缩合，最后Pd／C催化脱保护，历经16步反应最终得到产物多尼培南。

Using potassium persulfateas initiator and N, N′-methylenebisacrylamideas crosslinker, the graft copolymerization of acrylic acidonto modified cornhusk fiber was carried out.

将玉米秸秆进行提纯改性，采用过硫酸钾为引发剂、N，N-亚甲基双丙烯酰胺为交联剂，使其与丙烯酸接枝共聚合成农用高吸水树脂，通过试验对比最终确定最佳条件为改性玉米秸秆与丙烯酸的质量比为1∶6、丙烯酸中和度为70%、反应时间为4h、烘干温度为60°C；对最佳条件下制备的树脂进行了吸水倍率的测试；对秸秆预处理前后及接枝产物进行了红外谱图分析。

Table 1 medical packaging materials, containers, scope of pharmaceutical packaging materials, containers, in the form of the name preparation notes plastic bottle kalidehydroandrogropholidi = 50ml material with PP, LDPE Infusion bags, kalidehydroandrogropholidi = 50ml material is PVC, polyalkene glass infusion bottle 50ml clorsulon = injection bottle kalidehydroandrogropholidi 50ml, kalidehydroandrogropholidi = 50ml-molded, control of glass bottle kalidehydroandrogropholidi kalidehydroandrogropholidi 50ml kalidehydroandrogropholidi 50ml ampule medical plastic bottle of tablets, capsules, tablets, colour.10pills glass ampoules, pills and capsules, syrup, oral solution, nanosuspensions, immunoembolization, tincture, linimentum, lotio hard PVC medicinal Tablet and capsule-plastic blister packaging PVC/PE/PVDC medicinal compound hard Tablet and capsule-plastic blister packaging Composite PVC/PVDC medicinal Tablet and capsule hard-plastic blister packaging cold metal forming hard medicinal compound tablets, capsules, suppository materials have nylon/aluminium/PVC double aluminum packaging Tablet and capsule PVC/hard LDPE medicinal compound tablets, capsules, suppository glass bottle ciinincal ciinincal ciinincal plastic bottle medicinal ciinincal medicinal eardrops plastic bottle eardrops medicinal nasal drops plastic bottle nose drops for external use liquid medicinal plastic bottle tincture, linimentum, lotio koufuye of medicinal plastic bottle syrup, oral solution, nanosuspensions, immunoembolization glass control oral bottle syrup, oral solution, nanosuspensions, immunoembolization packaging for medicine bag laminating film, puivis bletillae, feian and Tablet foil Tablet and capsule of unguentum Al fighting、smoke aluminium pipe, oculentum, puivis bletillae, Tin aerosolon, nabulization materials have aluminum, plastic valve pyritionate, nabulization stopple kalidehydroandrogropholidi 50ml, 50ml clorsulon = material bromide, CIIR synthesis of oprene 50ml clorsulon = gasket aluminium caps combination Cap koufuye falchion, kalidehydroandrogropholidi 50ml, 50ml prestrain kalidehydroandrogropholidi = potting needle kalidehydroandrogropholidi 50ml desiccant tablets, capsules, pills and aluminium bottles vinpocetione polyethylene film and bag vinpocetione b, package management and standards on the management of the drug packaging mainly has two modes: a mode of government management, such as Singapore, Indonesia adopted a market access system, United States, Canada, the European Union through the implementation of the medicine on the packaging of the strict management, that is, the drug registration, declare to use medical packaging of related materials; Government departments on the packaging manufacturer production system to carry out spot checks.

表1 药品包装材料、容器适用的范围药用包装材料、容器名称制剂形式备注塑料输液瓶注射剂≥50ml 材料有PP、LDPE 输液膜、袋注射剂≥50ml 材料有PVC、聚烯烃玻璃输液瓶注射剂≥50ml 冻干注射剂瓶注射剂0ml、注射剂≥50ml 模制、管制玻璃注射剂瓶注射剂0ml 安瓿注射剂0ml 口服固体药用塑料瓶片剂、胶囊、丸剂玻璃药瓶片剂、胶囊、丸剂、糖浆剂、口服溶液剂、混悬剂、乳剂、酊剂、搽剂、洗剂 PVC药用硬片片剂、胶囊铝塑泡罩包装 PVC/PE/PVDC药用复合硬片片剂、胶囊铝塑泡罩包装 PVC/PVDC药用复合硬片片剂、胶囊铝塑泡罩包装冷冲压成型药用复合硬片片剂、胶囊、栓剂材料有尼龙/铝/聚氯乙烯双铝包装片剂、胶囊 PVC/LDPE药用复合硬片片剂、胶囊、栓剂玻璃滴眼剂瓶滴眼剂药用滴眼剂塑料瓶滴眼剂药用滴耳剂塑料瓶滴耳剂药用滴鼻剂塑料瓶滴鼻剂外用液体药用塑料瓶酊剂、搽剂、洗剂口服液体药用塑料瓶糖浆剂、口服溶液剂、混悬剂、乳剂玻璃管制口服液瓶糖浆剂、口服溶液剂、混悬剂、乳剂药品包装用复合膜、袋散剂、颗粒剂、片剂药品包装用铝箔片剂、胶囊铝管、铝塑管软膏、眼膏剂、散剂、罐气雾剂、喷雾剂材料有铝、塑料阀门气雾剂、喷雾剂胶塞注射剂0ml、注射剂≥50ml 材料有溴化、氯化丁基橡胶合成聚异戊二烯垫片注射剂≥50ml 铝盖、铝塑组合盖口服液、注射剂0ml、注射剂≥50ml 预灌封注射针注射剂0ml 干燥剂片剂、胶囊、丸剂铝瓶原料药聚乙烯膜、袋原料药二、包装管理及标准各国对药品包装的管理主要有两种模式：一种模式是政府管理，如新加坡、印度尼西亚采取市场准入制的方式，美国、加拿大、欧盟通过对药品的管理实施对药品包装的严格管理即在药品注册时，申报所使用药品包装的相关材料；政府部门对药品包装生产企业的生产体系进行现场检查。

Difunctional group reagents, which have metal and heteroatom linked to the olefinic carbon atoms, play an important role in organic synthesis, especially in developing many convenient methods for the stereoselective synthesis of substituted alkenes.

含金属或杂原子的双官能团试剂为取代烯烃的立体选择合成提供了许多方便方法，在有机合成中具有重要作用。

Polydicyclopentadiene is a novel engineering material synthesized by reaction injection molding method and such reaction mechanism is ring-opening metathesis polymerization.

聚双环戊二烯是采用反应注射成型工艺合成的一种性能优良的新型工程材料，是通过开环易位机理形成的聚合物。

The influences of N,N'-methene biacrylamide cross-linker,monomer concentration,polymerization time and temperature on swelling ratio were investigated,and reversibility of the hydrogels under various pH conditions at given temperature.

目的通过合成聚丙烯酸-co-α-甲基丙烯酸水凝胶，研究N，N'-亚甲基双丙烯酰胺交联剂、丙烯酸和α-甲基丙烯酸单体浓度、聚合时间对其水凝胶溶胀率的影响，以及温度和不同pH值时水凝胶的pH可逆性。

This paper reviewed the applications of strong organic base DBU in synthesis of phthalocyanine compounds.

文章介绍了有机碱1，8-二氮杂双环[5.4.0]十一-7-碳烯，作为一种有效的催化剂在酞菁类化合物的合成中的重要作用。

We prepared the pyrethric acid II through four reactions: esterification, oxidation, decomposition, diesterification. And the original synthesis route of the pyrethric acidII was improved: the yield of oxidation of allyl rise through increasing the activity of Selenium dioxide; in the document, tert-butyl-trans -2, 2-dimethy1-3-(2"-methoxycarbony1-1"-propenyl)cyclopropanecarboxy late was synthesized from tert-butyl-trans-2,2-dimethyl-3-(2 -formyl-r -propenyl) cyclopropanecarboxylate with two steps, with low yield.

我们经过酯化，氧化，成双酯，热分解四步反应，成功地得到了第二菊酸，并改进了原第二菊酸的合成路线：通过改变二氧化硒的活性提高了烯丙甲基的氧化产率；将原路线中醛氧化成羧酸、羧酸酯化的两步反应改为醛和甲醇、二氧化锰等作用一步直接酯化的方法，减少了反应步骤，提高了总收率。

The reaction of sodium alkylcycloperitadienide with metal chlorides gave derivatives of bisdichlorides of titanium, zirconium and hafnium where alkyls were n-propyl and n-butyl.

本文报导烷基环戊二烯基钠与金属氯化物反应合成钛、锆和铪的双金属二氯化物以及通过卤素交换制备双钛的二氟化物的方法。

A new train of thought of copolymerising modification of the boron phenolic resin was applied and a new resin contained allyl was synthesized through allyl phenol, phenol, boric acid and polyformaldehyde.

运用硼酚醛树脂共聚改性的新思路，利用烯丙基苯酚、苯酚、硼酸、多聚甲醛等合成出结构中含有烯丙基活性基团的可与其它含不饱和双键树脂发生共聚反应的新型硼酚醛树脂，表征了它们的物理性能和结构。

We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称；三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起，称之为挽歌体诗人或者史诗诗人，他们被称为诗人，似乎只是因为遵守格律写作，而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。