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Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我们以水杨酰胺为起始原料,经Reformatsky反应、烷基化、Diekmann环合、烯醇化、酯化等反应合成双环母核2;再从L-羟基脯氨酸出发,经酯化保护羧基、保护氨基、保护羟基、硼氢化还原酯得醇、Sn2取代和Mitsumobu反应等合成巯基侧链3;最后由化合物3经脱保护、水解得硫醇,和化合物2在二异丙基乙基胺的作用下缩合,最后Pd/C催化脱保护,历经16步反应最终得到产物多尼培南。

We have reviewed the researches on synthesis and application of nanoalloys and bimetallic NPs with core-shell structure reported in recent years.

本文综述了近年来有关核壳结构双金属纳米粒子合成与应用方面的研究结果。

Methods 60 patients with newly diagnosed ITP, their serum TPO concentration were detected by double-antibody sandwich enzyme-linked immunosorbent assay; and the bone Marrow megakaryocytes were recorded; HP was detected by 14C urea breath test. The control group of 40 cases was also detected by above methods.

60例初治ITP患者,在接收治疗前采用双抗体夹心酶联免疫吸附法检测血清TPO水平,计数骨髓涂片的平均巨核细胞数量,用14C尿素呼气试验检测患者HP感染情况。

Numerical results of single solid/core-shell and two cylindrical nanorods under plane electromagnetic wave with resonance frequency are presented.

本研究主要探讨不同细长比之单、双颗实心或核-壳细杆形金奈米粒子於电、磁场中受到平面波或电偶极波源时,散射体的表面电浆子现象。

In the late of April of the second year, male inflorescences unbound and pollinated. When female inflorescences accepted the pollen grains, ovary development was increased in early May. With the development of either of the two ovule, funiculus, integument and nucellus were differentiated. Embryo sac mother cell came into being and the meiosis begins. Then fuctional megaspore developed into matured embryo sac that contain eight nucleuses. In the end of May, double fertilization generated.

次年,4月下旬,雄花序解螺旋散粉,雌花序开花授粉;5月上旬,雌花序授粉后,迅速增长,子房膨大,两个胚珠分化出珠柄、珠被和珠心,珠心中产生孢原细胞;5月中下旬,大孢子母细胞形成并减数分裂,功能性大孢子形成成熟的八核胚囊;5月底,发生双受精。

Using the semiclassical rescattering model, we have studied the effect of molecular internuclear distance on non-sequential double ionization.

利用半经典再散射模型,我们研究了激光强度在一定范围内时分子核间距对非时序双电离过程的影响。

Series of octahedral core-shell emulsion microcrystal with different distribution of iodide ions was prepared by double-jet method.

本文应用双注法制备了一系列碘分布不同的八面体核壳乳剂。

For double jet method, effects of used solvent, shape of stirrer, adding reactant position, reaction temperature, excessive silver ion concentration in reaction solution and adding rate on the nucleus formation, and growth of silver behenate crystal were systematically studied.

本文分别采用单注沉淀法和双注沉淀法制备了山嵛酸银晶体,通过对两种制备方法的对比及优选,最后确定双注沉淀法更适合制备细粒径的山嵛酸银,通过采用SEM、TEM等对山嵛酸银晶体形貌的表征发现,制备山嵛酸银所使用的溶剂、搅拌方式、加料的位置、反应温度、反应初始液中银离子浓度及加料速度等,均对山嵛酸银的晶体成核与生长有一定的影响。

These excellent properties of 9E-BHVC all mentioned above imply that it would be a true two-photon nucleic acid fluorescent probe if it can specially recognize the DNA in complex cellulous environment.So this dissertation has investigated the ability of 9E-BHVC on the cell nucleus imaging detaily.

与BMVC相比,9E-BHVC表现出作为双光子荧光探针更好的特性,例如具有更大的活性吸收截面和更高的结合常数,且具有更好的水溶性。9E-BHVC这些优良的性质预示着该分子如果能够在复杂的细胞环境中特异性地识别DNA,那么它将是真正意义的双光子核成像探针。

Compared to BMVC,9E-BHVC has many better features needed by a two-photon probe,such as larger two-photon action cross sections,stronger affinity to DNA and better water-solubility.These excellent properties of 9E-BHVC all mentioned above imply that it would be a true two-photon nucleic acid fluorescent probe if it can specially recognize the DNA in complex cellulous environment.So this dissertation has investigated the ability of 9E-BHVC on the cell nucleus imaging detaily.

与BMVC相比,9E-BHVC表现出作为双光子荧光探针更好的特性,例如具有更大的活性吸收截面和更高的结合常数,且具有更好的水溶性。9E-BHVC这些优良的性质预示着该分子如果能够在复杂的细胞环境中特异性地识别DNA,那么它将是真正意义的双光子核成像探针。

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However, as the name(read-only memory)implies, CD disks cannot be written onorchanged in any way.

然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

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A single payment file can be uploaded from an ERP system to effect all pan-China RMB payments and overseas payments in all currencies.

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