双受体

In the third part of this dissertation, based on the leading compound ACPD, we design and asymmetric syhthesized two analogues: 56 and 57 by using Seebach's self- regeneration strategy to synthesize α,α-disubstituted amino acid as the key step.

论文的第二部分，我们利用我们所开发的合成α，α双取代氨基酸的方法，以对甲基苯甲醛为原料，经过分子内付克烷基化、氧化银氧化和氢化等16步反应，完成了代谢型谷氨酸受体拮抗剂-AIDA的不对称合成。

Here, we show that mutations in GPR56, which encodes an orphan G protein–coupled receptor with a large extracellular domain, cause a human brain cortical malformation called bilateral frontoparietal polymicrogyria.

作者发现编码一个带有较大胞外区的孤儿G蛋白耦联受体的基因GPR56的突变导致人类大脑皮质畸形（双侧额顶多小脑回畸形BFPP）。

ARR4 responded to cytokinins at early time of seed germination, especially on the 6 d when seedlings were around true leaf initiation, while cyto- kinins induced ARR5 activation after 6 d of seed cul- tivation in light conditions, an obvious increase was on the 20 d when seedlings were around inflorescent shoot initiation.

在双组分信号传导途径中，从受体到反应调节基因传导磷酸基团的传导基因AHP4在幼苗发育的后期种子萌发后的第20和30天，应答植物体内增加的植物细胞分裂素，并且在花枝形成初期比较明显。

In a randomized, placebo-controlled, double-blind, crossoer study, 24 subjects with type 2 diabetes and one subject with partial lipodystrophy and diabetes due to dominant-negatie mutation in the peroxisome proliferator-actiated receptor- gene (P467L) receied placebo and rosiglitazone for 3 months.

在一项随机、安慰剂对照、双盲、交叉的实验中，24例2型糖尿病和1例因过氧化物酶增殖体激活受体基因(P467L)显性负向突变导致部分脂肪营养不良和糖尿病的患者接受了3个月的安慰剂和罗格列酮治疗。

Plasmid DNA of pBILGC containing Chitinase and β-1, 3 - glucanase gene and fresh pollen of Papaver nudicaule were mixed in 11％ sucrose solution, then the pollen suspension were pollinated on stigmas of the Papaver nudicaule by artificial pollination.

以野罂粟开放花蕾为受体，以载有几丁质酶和β-1，3-葡聚糖酶基因双价植物表达载体pBLGC的质粒为供体，在11％浓度的蔗糖溶液中，加入花粉和含有目的基因的质粒DNA。得到药粉处理液。

Methods Eighty Class Ⅱ isogeneic F344 rats, weighing 250-350 g, were randomly divided into 2 groups(n=40). The control group adopted the Strome model. The allograft used for the experimental group preserved ascending pharyngeal artery, which formed a complex allograft together with tongue base, larynx and pharyngolarynx. End-to-end anastomosis was performed between both allograft common carotid arteries and anterior neck veins. The patency rate and survival rate of the allograft of the 2 groups were compared.

80只Ⅱ级近交系F344大白鼠，体质量250~350 g，随机分为2组，每组40只，共20对对照组采用Strome喉移植模型，实验组在切取供体喉时保留咽升动脉，将舌根、喉、喉咽作为复合移植体，供体大鼠双侧颈蓉动脉分别与受体大鼠颈总动脉、颈前静脉进行端端吻合重建移植喉血液循环，比较两组术后动静脉通畅率及移植喉存活率。

Novel styryl derivatives with triphenylamine as donor and triazine as acceptor were synthesized. The two-photon absorption cross section for Ⅴ-1,Ⅴ-2 and Ⅴ-3 were determined to be 0.31×10〓cm〓/Gw, 0.365×10〓cm〓/Gw and 1. 64×10〓cm〓/Gw by femtosecond Z-san technology, respectively.

合成了以三苯胺为电子给体、三嗪为电子受体的新型二苯乙烯类化合物，用飞秒开口z-扫描测量化合物Ⅴ-1、Ⅴ-2和Ⅴ-3的双光子吸收截面分别为0.31×10〓cm〓/Gw、0.365×10〓cm〓/Gw和1.64×10〓cm〓/Gw。

Regulating the control group used traditional western medicine treatment: The application of the latest "chronic congestive heart failure treatment recommendations"China cardiovascular disease magazine, 2002; 30 (1 :7-21 Recommend the most appropriate method of treatment, According to patients after hospital-based treatment of illness:① general routine treatment: rest, salt restriction, oxygen, etc.;② to the diuretic (urine dihydrochloride grams thiadiazole 25 ~ 50 mg or 20 mg furosemide, antisterone 20 mg, 1 to 3 times daily oral);③ ACEI:(captopril 625 mg, twice daily beginning);④β-receptor blocker (metoprolol from 6.25 mg daily oral dose of 1 start);⑤ cardio (digoxin 0.25 mg daily oral administration, a week after the condition of patients based on the alignment of their drug dosage or suspension).

对照组采用西医规范治疗：采用最新的《慢性充血性心力衰竭治疗建议》（中华心血管病杂志，2002；30（1）：7—21）推荐的最适合的治疗方法，患者入院后即根据病情进行基础治疗：①一般的常规治疗：休息、限盐、吸氧等；②予利尿（双氢克尿噻25~50mg或速尿20mg、安体舒通20mg，每日1~3次口服）；③ACEI：（开搏通6.25mg，每日2次开始）；④β一受体阻滞剂（倍他乐克从6.25mg，每日1次口服开始）；⑤强心（地高辛0.25mg，每日一次口服，一周后依据患者的病情，调整其用量或暂停药）。

METHODS: 12 GABAA and 1 glycine receptors were expressed in Xenopus laevis oocytes and studied using two-electrode voltage clamping.

12 GABAA 和 1甘氨酸受体能在非洲爪蟾卵母细胞中表达并且通过双电极电压钳夹法研究测得。

MAIN OUTCOME MEASURES: At 3, 7, 14, 28 days after the application of traction and 3, 7, 14, 28 days after the removal of traction, the expression of receptor activator of nuclear factor κB ligand/osteoprotegerin in the subchondral bone of the bilateral condyles was analyzed by semi-quantitative immunohistochemistry.

主要观察指标：加力3，7，14，28 d及撤除外力后3，7，14，28 d，以免疫组织化学半定量检测双侧髁状突软骨下骨中核因子κB受体活化因子配基/骨保护素表达。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐