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The results observed showed that pathological changes consisting of destructive meningoencephalitis and large, basophilic, intranuclear and acidophilous intracy toplasmic neuronal inclusions of viral type occurred in the fetal mouse brain.

待雌鼠临产时剖腹取出胎鼠脑双侧大脑皮层,进行病毒分离、病理学检测及用地高辛标记的HCMV寡核苷酸探针对大脑皮层细胞压印片进行原位分子杂交检测。

The above results proved that atrazine could be inserted into the double-helix of DNA and formed a stable DNA adduct.

以上实验结果表明,莠去津平面分子能够嵌插到DNA双螺旋链中,形成较稳定的加合物。

The ratio of the symmetrical diatomic molecule generates more than the atomics because of charge resonance in theory.

对称双原子分子由于电荷共振,理论上比原子有更的谐波产生率。

Extending the model to binary compound, an equation of state for double-component phospholipid monolayers was derived.

将上述状态方程推广到二元混合物,导出了双组分磷脂单分子膜的状态方程模型。

The objectives of this paper are to study a new simple calculation of elements' electronegativity and bond energy in double-atom molecules and to explore its physical significance.

研究了电负性和双原子分子键能的一种简单算法,并对其物理意义作初步探讨。

These excellent properties of 9E-BHVC all mentioned above imply that it would be a true two-photon nucleic acid fluorescent probe if it can specially recognize the DNA in complex cellulous environment.So this dissertation has investigated the ability of 9E-BHVC on the cell nucleus imaging detaily.

与BMVC相比,9E-BHVC表现出作为双光子荧光探针更好的特性,例如具有更大的活性吸收截面和更高的结合常数,且具有更好的水溶性。9E-BHVC这些优良的性质预示着该分子如果能够在复杂的细胞环境中特异性地识别DNA,那么它将是真正意义的双光子核成像探针。

Compared to BMVC,9E-BHVC has many better features needed by a two-photon probe,such as larger two-photon action cross sections,stronger affinity to DNA and better water-solubility.These excellent properties of 9E-BHVC all mentioned above imply that it would be a true two-photon nucleic acid fluorescent probe if it can specially recognize the DNA in complex cellulous environment.So this dissertation has investigated the ability of 9E-BHVC on the cell nucleus imaging detaily.

与BMVC相比,9E-BHVC表现出作为双光子荧光探针更好的特性,例如具有更大的活性吸收截面和更高的结合常数,且具有更好的水溶性。9E-BHVC这些优良的性质预示着该分子如果能够在复杂的细胞环境中特异性地识别DNA,那么它将是真正意义的双光子核成像探针。

The molecular designs and synthesis of triarylamine-based picolinic acid derivatives used as ancillary ligands, and their cyclometalated iridium complexes used as red-and green-emitters, as well as optoelectronics properites of these compounds were investigated in order to solve current problems of organic/polymeric electroluminescent materials and devices.

本论文针对目前有机/聚合物电致磷光材料和器件存在的问题,开展了新型三芳胺吡啶羧酸类辅助配体及其红光和绿光环金属铱配合物电致磷光材料的分子设计、合成和光电性能研究,主要包括:(1)设计、合成了三种新型的三芳胺吡啶羧酸类双齿阴离子型辅助配体;(2)以三芳胺吡啶羧酸衍生物作为双齿阴离子型辅助配体,合成得到了两个系列的红光和绿光环金属铱配合物;(3)研究了三芳胺吡啶羧酸类辅助配体分子结构对环金属配合物的紫外吸收和光致发光性能的影响;(4)以环金属配合物为客体,聚芴和恶二唑衍生物为主体,制作了聚合物电磷光器件,研究了含三芳胺吡啶羧酸类辅助配体、环金属配合物客体材料和聚合物主体材料等分子结构对电致发光性能的影响。

NodD binds to and bends target promoters through anchoring two tandem and individual specific DNA sites. NodD functions as a tetramer, which has a V-shaped main body. Tetrameric NodD is to change its own conformation rather than its oligomeric forms in response to small signal molecules. The specific interaction between each NodD DNA-binding domain and each specific DNA site does not alter itself in spite of naringenin induction, and the induced conformational change is transferred from protein to DNA. Only the DNA conformation incited by induced NodD is competent for RNA polymerase to form the transcriptional open complex. It cannot be excluded that NodD may have protein-to-protein contacts with RNA polymerase, and that the NodD conformational change may also directly contribute to the transcriptional open complex formation. However, the NodD conformational change itself cannot serve as the determinant of the transcriptional molecular switch.

通过研究,我们提出了初步的NodD操纵子激活模型:第一,四聚体是NodD蛋白的功能单位,它通过铆钉两个串联的相对独立的DNA靶位点结合被诱导的启动子;第二,小分子配基的结合是改变NodD四聚体的构象而不是引发不同形式的寡聚体,在我们的模型中,NodD四聚体缩小其V形主体的弯折角,进而缩短其DNA结合功能域的间距;第三,小分子信号的诱导并没有改变NodD的DNA结合域和其DNA靶位点的相互作用,NodD的构象改变由蛋白质经其双铆钉位点传递给DNA;第四,只有诱导状态的NodD激发的DNA构象才能有效地使RNA聚合酶形成转录开放复合物;第五,不排除NodD与RNA聚合酶可能有直接的相互接触位点,不排除NodD构象的改变可能直接有利于RNA聚合酶形成转录开放复合物,但是我们认为NodD构象改变本身不是充当转录激活开关的决定因素。

Sol–gel/diaminobenzoic acid hybrid materials were also generated to be used as the MALDI matrices for the analysis of oligonucleotides. It is because that DABAs have good molar absorptivity at wavelength of 337 nm. Furthermore, two amino functional groups attached to the aromatic ring in DABAs can also suppress the cation adductions of oligonucleotides and leave the protons to the oligonucleotides during MALDI-MS analysis. This matrix system can be used as an alternative for the analysis of oligonucleotides.

本论文也利用双胺基苯甲酸与溶胶凝胶混成产物当做MALDI基质来分析DNA分子,利用双胺基苯甲酸本身具有吸收雷射的特性,且其含胺之官能基可和钠、钾离子竞争DNA上磷酸根的负离子结合部位,因此可和DNA有较强的亲合力,而在脱附游离的过程中并可转移质子给磷酸根,可有效降低盐类的干扰,此一基质系统可取代传统MALDI基质混合胺盐的效果,适合用於DNA样品的分析。

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The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了,排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意,我建议我们在价格上大家各让一半。

After an hour and no pup, look for continued contractions and arching of the back with no pup as a sign of trouble.

一个小时后,并没有任何的PUP ,寻找继续收缩和拱的背面没有任何的PUP作为一个注册的麻烦。