双位

The endocyclic Sn atoms exist in a distorted triginal bipyramidal geometry with the coordination number of 5. The exocyclic Sn atoms form 6 significant bonds and exist in a distorted octahedron geometry.

化合物12的X衍射单晶测定表明，化合物是以Sn2O2四元环为中心的中心对称二聚体结构、内环锡为5配位的畸变三角双锥结构、外环锡为6配位的畸变八面体结构。

In all those complexes, no matter which conformation IDA assumes (mer- or fac-style), the two 0 atoms of 1N2O are both from carboxylic hydroxyl. However, by comparing the bond length, we can find that O(4) and O(2) atom is from different group in this complex, 0(4) atom from carboxylic hydroxyl, whereas, 0(2) from carboxylic carboxide.

值得注意的是：在这个双核配合物中，我们首次发现一种新颖的配位方式：IDA上与金属离子配位的三齿螯合原子是亚氨N原子、一个羧基上的羟基O原子和另外一个羧基上的羰基O原子。

When the investigators saw him at age four years, they found him on physical examination to be normal except for having two to three cm of dry, erythematous patches on both cheeks, as well as "mildly dry" skin on the flexor/extensor surfaces of both arms. They subjected him to a standard battery of tests and found negative results on skin prick testing to milk, eggs, peanuts, and dust mites, and serum IgE testing was also negative.

在这位男童四岁时，研究人员对他进行诊疗，在理学检查时发现，除了双颊2到3公分的乾躁、红肿斑块，以及双手伸肌或是屈肌的表面轻微乾躁外，大部分都是正常的；研究人员请这位男孩接受标准电池测试，结果发现皮肤刮痕试验结果对牛奶、鸡蛋、花生与尘蹒没有过敏反应，而且血清IgE试验呈阴性反应。

At that moment, the lead singer looked at me and said "This is for the woman with the beautiful green eyes" and began playing the song "At Last" by Etta James.

这位领班歌手看着我说，&这首歌献给这位长一双美丽青春绿眼睛的女子&说着就奏起埃特。詹姆斯作的曲&终于&。

In this thesis, a series of complexes based on aromatic multicarboxylic acids have been successfully synthesized in solutions or under hydrothermal conditions. Their structure and properties are investigated.(1) Eight complex compounds have been synthesized and characterized by X-ray single crystal diffractive technology: The eight complexes are listed as following: [Cu242] complex 1 [Cd22(H2O)4]·4H2O complex 2 [Co(H2btc)(H2O)3] complex 3 [Co2(H2O)2]·H2O complex 4 [Ni22(H2O)4] complex 5 [Cu22(H2O)4] complex 6 [Co(H2biim)2(H2O)2](H2btc) complex 7 [Zn(H2biim)2(H2O)2](H2btc) complex 8 The structure of complex 1 is dinuclear complex resulted from weak interactions（0-D chain）; complex 2 is 1-D chain stucture result from interactions of water molecules; complex 3、4、5、6 are coordination polymers using hydrothermal synthses, where the first kind ligand is H4btc, the second kind ligand is phen and Co2+、Ni2+、Cu2+ as center ions, respectively. While the coordination enviroment of Co2+ is the same in complex 3, the coordination geometries around the Co atoms in complex 4 are obviously different because of the different reaction conditions. In complex 4, the 1-D chains are connected into 2-D layer through carboxy groups of ligand H4btc. The structures of complex 5、6 are 1-D chain stucture result from interactions of carboxy groups in ligand H4btc. Complex 7、8 are homeomorphy compounds. Either of them are linked to the 3-D chains through intermolecular hydrogen bonds. Each H4btc lose two protons and H2btc2- acts as negative electron balance.

合成了8个结构新颖的配合物，并用X-射线单晶结构分析方法确定了晶体结构，分别为： [Cu242] 配合物1 [Cd22(H2O)4]·4H2O 配合物2 [Co(H2btc)(H2O)3] 配合物3 [Co2(H2O)2]·H2O 配合物4 [Ni22(H2O)4] 配合物5 [Cu22(H2O)4] 配合物6 [Co(H2biim)2(H2O)2](H2btc)配合物7 [Zn(H2biim)2(H2O)2](H2btc)配合物8 配合物1是一个依靠弱作用连接的双核铜结构；配合物2借助水分子形成一维链状结构；配合物3、4、5、6是以H4btc为第一配体、phen为第二配体，通过水热法合成的配合物，其中，Co2+、Ni2+、Cu2+为中心离子；配合物3中的二价钴离子具有相同的配位环境，不同反应条件下得到的配合物4中的二价钴离子存在不同的配位环境，在配合物4中，一维链通过H4btc上的羧基形成一个二维层结构；配合物5、6是借助H4btc上的羧基形成的一维链状结构；配合物7、8属于异质同晶结构，它们的分子通过分子间氢键形成三维网状结构，H4btc上的羧基失去2个质子，作为一个二价负离子起到电荷平衡作用。

Second, residues in the reactive site of the inhibitor were replaced by the consensus substrate recognition sequence of furin, namely, Arg at P_1, Lys at P_2, Arg at P_4 and Arg at P_6. In addition, the P_7 residue Asp was substituted with Ala to avoid possible electrostatic interference with furin inhibition. Finally, the extra N and C terminal residues beyond the doubly conjugated disulfide loops were further truncated. However, all resultant synthetic peptides were found to be temporary inhibitors of furin and kexin during a prolonged incubation, with the scissile peptide bond between P1 and P'1 cleaved to different extents by the enzymes.

高活性、低分子量的furin酶抑制剂有可能发展成为新型的抗细菌内毒素和抗病毒感染的药物，我们以绿豆胰蛋白酶抑制剂Lys片段长链22肽为模板，设计了一系列能抑制furin和kexin活性的突变体，采用如下三种方法逐步优化：一、去除Lys片段长链三对二硫键中的一对，用Ser替换Cys，减少可能存在的二硫键错误配对；二、抑制剂的活性中心根据furin底物的专一性逐步改变，即P1、P2、P4和P6位分别变为Arg、Lys、Arg和Arg，同时为了避免P7 Asp和P6 Arg之间可能存在的相互作用，将P7位Asp替换为Ala；三、将两对二硫键形成的双环的外面5个氨基酸残基去除。

The thickness of the inner wall was (0.68±0.46) mm. It showed no significant difference between the two sides of the optic canal in diameters(P＞0.05).(2)The optic canal, the superior orbital fissure and the inferior orbital fissure were respectively shown as track, crack and gorge type in CT axial pictures, while in the coronal pictures, they were respectively shown as butterfly eyes, horizontal fissure and vertical fissure type.(3)The relationship of the posterior ethmoid sinus and the optic canal was: anterocanal(42.00%), semicanal(27.5%), whole-canal(18.75%),sella turcica(9.75%) and circumcanal(2.00%).(4)The relationship of the position of the sphenoidal sinus and the optic canal was:Ι degree sphenoidal sinus(20%),Π degree (63%) and Ш degree (17%).

双侧间差异均无显著性（P＞0.05）；②视神经管、眶上裂、眶下裂在CT轴位像上分别表现为&轨道状&、&裂隙状&和&狭谷状&，在冠状位像上分别表现为&蝶眼状&、水平状裂隙和垂直状裂隙；③后组筛窦与视神经管的位置关系为：管前型占42.00%、半管型占27.50%、全管型占18.75%、蝶鞍型占9.75%和管周型占2.00%；④蝶窦气化度与视神经管的位置关系为：Ι度蝶窦占20%、Π度蝶窦占63%和Ш度蝶窦占17%；⑤视神经管内侧壁骨质缺损发生率为25.5%，缺损平均长度为(5.07±2.52)mm。

Several novel structures have been determined: Unique ninenuclear complexesincorporating 3d, 4f metals with a sodium ion center, the sodium ion may be serve as atemplate in the formation of these novel complexes; Novel tetranuclear 〓complexes with channels formed by intermolecular weak interactions; First 〓type tetranuclear complex; Peculiar "dimer of dimers" complexes derived frombinuclear complex; Unusual one-dimensional wave chain formed by weakcoordination bonds and hydrogen bonds and two dimensional coordination polymerconstructed through coordination bonds and hydrogen bonds.

1获得了多个文献首报和罕见的特殊结构的配合物：两个同时含有碱金属-过渡-稀土金属的独特的九核配合物；两个具有孔道的稀土-过渡金属异四核配合物；草酰胺类〓四核配合物；两个由双核配合物通过叠氮和单个氯原子连成的四核配合物，尤其是以单个氯桥相连的化合物非常少见；一个由弱配键和氢键连成的具有一维波浪形结构的配合物；一个通过配位键和氢键连成的二维配位聚合物。

The synthetic route is concise and convenient. In chapter four, a serial of dithienylethene derivatives containing substituted triphenylamine groups was synthesized with a concise route.

第四章通过Suzuki反应，制备了在噻吩环的5-位上有单三苯胺取代的二噻吩乙烯，和5-，5'-位双三苯胺取代二噻吩乙烯光致变色化合物。

In compound 1, Co is in a distorted octahedron environment with four nitro-gen atoms from the tripodal ligand and two oxygen atoms from the bridged oxalate, and the molecule is a dimmer-ic structure consisting of two LCo unites linked by bridging oxalate.

在配合物1中，Co与来自三脚架配体的4个氮和草酸根桥联配体的2个氧原子配位，处于扭曲八面体配位环境。由草酸根桥联两套LCo，构成了一个双核结构。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。