参数化的

OBJECTIVE To design and develop a clinical pharmacokinetics and individual drug dosage regimens system CPKDP program for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS According to the principle of population pharmacokinetics and Bayes" formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient"s pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.

目的为利用临床常规监测的血药浓度数据估算病人的个体药动学参数，优化给药方案，设计、研制了临床药动学给药个体化系统CPKDP程序方法依据群体药动学原理及Bayes公式，CPKDP程序用FOXPRO 2.6和BORLAND C++ 3.1开发，在希望汉字系统UCDOS 5.0平台上运行结果CPKDP程序适用于具有不同药动学特征的多种药物，适用于不同给药途径的单剂量或多剂量给药在群体药动学参数的基础上，结合病人个体特征，以1，2个血药浓度作为反馈，即可拟合估算个体药动学参数，优化给药方案结论经初步应用，CPKDP程序是应用Bayes反馈法开展临床个体化给药工作非常实用的工具

Based on LSER method, the relationship between the acute toxicity of 26 substituted aromatic compounds on Photobacterium phosphoreum, Daphnia magna and fathead minnow and their theoritical solvatochromic parameters, the high correlation were found, it provided an example to introduce the quantum chemical parameters into QSAR study.

以线性溶剂化能相关理论为基础，利用理论溶剂化参数分析了26种取代芳香化合物对呆鲦鱼、发光菌和大型蚤的急性毒性，为成功地将量子化学参数引入QSAR研究探寻了一条新路。

The experiment results prove that the way with regularization technology is better than the way without regularization technology. In order to overcome the limitation of the regularization method, chapter 6 builds an irregular MRF model suitable for the motion estimation of feature point based on MAP-MRF frame. The energy function, which can reflect the joint probability distribution of motion parameters and the constraints relation of local 3D motion parameters, is established in irregular MRF.

为了解决正则化方法只能分析非刚体局部三维运动的缺点，第6章在基于MAP-MRF的分析框架中建立了与特征点运动估计相对应的非规则MRF模型，构造了非规则MRF模型中反映非刚体局部三维运动参数之间约束关系和运动参数联合概率分布的能量函数，通过能量函数最小化估计运动参数。

The effects of technical parameters of laser surface alloying processing on the qualities of the alloyed layer of rocker arm used in motor were investigated with orthogonal test,and the factors and their levels were analyzed.

采用正交试验，对激光表面合金化工艺参数进行了优化，分析了各工艺参数对气门摇臂合金化层质量的影响。

The method comprises the following steps: a conversation initialization request message transmitted by a service requester is received, wherein the request message comprises an application service quality parameter and service description information; according to the application service quality parameter and the service description information, a access protocol intermediate node of the corresponding simple object and a service provider are selected; according to the intermediate node and the service provider, access protocol routing information of the corresponding simple object can be acquired; and the conversation initialization request message containing the access protocol routing information of the simple object is transmitted to the corresponding service provider.

本发明方法包括：接收服务请求方发送的会话初始化请求消息，所述会话初始化请求消息中包含应用服务质量参数以及业务描述信息；根据所述应用服务质量参数以及业务描述信息选择对应的简单对象访问协议中介节点以及服务提供方；根据所述简单对象访问协议中介节点以及服务提供方获取对应的简单对象访问协议路由信息；向对应的服务提供方发送包含所述简单对象访问协议路由信息的会话初始化请求消息。本发明还提供一种路由系统以及相关设备。

After that , simulated the Die Casting filling process of liquid metal .First use the spical soft Pro/E to construct the model of Die Casting part; Input it to another soft I-deas to form mesh and put the mesh document to the special soft ProCAST.

接着模拟了金属液在模具型腔的充填过程：运用Pro/E软件对泵盖进行三维实体造型，然后把图形导入软件I-deas中进行网格化处理，并将网格化后的模型输入到ProCAST软件中进行了关于压铸工艺参数的多组正交试验的流场，温度场的偶合模拟，进而从多组试验参数中找出最优的压铸工艺参数。

Pasting-parameters of maize varieties could be used to predict the extruded qualities and system parameters in the procedures of extrusion.

玉米品种的糊化参数可用来预测挤压膨化产品的质量以及挤压膨化加工时的系统参数。

80 Mm special alloy steel wire for metal card clothing were studied,and their technique parameters were respectively found out.

研究了φ2.15mmSWRH72B、金属针布专用φ3.50mm合金钢Ⅰ和φ3.80mm合金钢Ⅱ三种钢丝的球化退火工艺，分别找出了其最佳的球化退火工艺参数；同时分析了球化退火工艺参数对最终碳化物球粒度的影响。

This parameter canaccurately describe the degree of concentration of vibratory energy of the systemmodal shape in quantity. Using this parameter, the effects of mistuning on thelocalization of system modal shapes for various orders are studied. The reasons of themodal localization phenomenon are analyzed by the perturbation method.

利用所提出的模态局部化参数，研究了失谐对叶盘系统各阶模态局部化程度的影响规律，并利用摄动法对失谐所导致的模态局部化现象进行了分析；同时还发现，失谐叶盘系统的某些中间阶模态的局部化参数值在弱耦合区域的特定位置会产生奇异的突变现象，而这种突变现象是用摄动法难以解释的，并且可能会对失谐叶盘系统的振动稳定性产生重要影响。

With the optimization of the test results, the best extrusion system parameters were obtained based on the filtration time of worts. And the main indexes of worts under the best extrusion system parameters were better than the control's.

通过对试验结果的优化分析，得到了以糖化醪过滤时间为指标的大米啤酒辅料挤压膨化系统最佳参数；在此参数下所制辅料，经糖化后所得麦汁的各项指标均优于对照。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。