参数化法

OBJECTIVE To design and develop a clinical pharmacokinetics and individual drug dosage regimens system CPKDP program for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS According to the principle of population pharmacokinetics and Bayes" formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient"s pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.

目的为利用临床常规监测的血药浓度数据估算病人的个体药动学参数，优化给药方案，设计、研制了临床药动学给药个体化系统CPKDP程序方法依据群体药动学原理及Bayes公式，CPKDP程序用FOXPRO 2.6和BORLAND C++ 3.1开发，在希望汉字系统UCDOS 5.0平台上运行结果CPKDP程序适用于具有不同药动学特征的多种药物，适用于不同给药途径的单剂量或多剂量给药在群体药动学参数的基础上，结合病人个体特征，以1，2个血药浓度作为反馈，即可拟合估算个体药动学参数，优化给药方案结论经初步应用，CPKDP程序是应用Bayes反馈法开展临床个体化给药工作非常实用的工具

Firstly, the approach formulates a cost functional to turn the inverse problem into a constrained minimization problem according to least squares criterion, then the resulting constrained minimization problem is transformed into an unconstrained minimization problem by using a penalty function technique, and then the closed Fr chet derivatives of the Lagrange function with respect to the properties are derived based on the calculus of variations, finally, one can solve the resulting problem by using any gradient-based algorithm and the finite-difference time-domain method.

该方法首先以最小二乘准则构造目标函数，将逆问题表示为约束最小化问题；接着应用罚函数法转化为无约束最小化问题；然后基于变分计算导出闭式的拉格朗日函数关于特征参数的Fr chet导数；最后借助梯度算法和时域有限差分法迭代反演德拜模型参数。

From the results obtained in the study, the following conclusions can be made:The methylene blue and spectrophotometer method can capture the free radicals generated successfully. This is an effective way to measuring the free radicals quantitatively in cavitation, moreover it is easy to fulfill.The intensity of cavitation increases with reduction in the cavitation number. But the different mechanism of various enhancive processes (chemical and physical processes) results in different effect by cavitation number.The effect of operating parameters, such as inlet pressure, temperature and time on cavitation indicate that optimum operating conditions exist at the cavitation enhancive effect is maximum.It is important to optimize the structure of hydrodynamic cavitation reactor for achieving a desired effect. A reasonable geometric parameter can promote the enhancive effect for a fixed hydrodynamic condition.Ventilating appropriate gas to cavitating flow can increase cavitational intensity and hence promote the enhancive effect of hydrodynamic cavitation.

研究结果表明：亚甲基蓝分光光度计法，能够成功地捕捉到水力空化产生的羟自由基，是定量检测空化自由基简便易行的有效方法；空化程度随空化数的减小而增强，但对于不同的强化过程，因其强化机理不同，故空化数对强化效应的影响也不同；水力空化系统的压力、温度及时间等操作参数对空化强化效应的影响规律表明：在适宜的操作条件下可产生最佳的空化强化效果；空化发生器结构的优化设计是保证空化强化效应的重要前提，在一定的水力学条件下，合理的结构尺寸可以增强空化作用效果：往水流中适量加入干扰气体能够提高空化强度，增强空化强化效果。

The following conclusions have been made in this paper.(1) Based on CO_2 flux data of eddy covariance, variation characteristics of gross primary productivity in four flux observation stations were studied, which are an alpine meadow, an alpine shrub meadow, a swamp alpine meadow and a steppe alpine meadow at Dongxiong. The results show that photosynthetic capacity of the alpine meadow is the highest, and the annual total GPP is 652.2g C/m~2. Daily-differencing approach is used to analyze the random error of CO_2 fluxes measurements. The results show that the distribution of random error follows more closely follows a double-exponential, rather than a normal distribution, capturing the high peak and thick tail, and the random error varies with environment variables, which violates the assumptions for the ordinary least squares fitting with normality and homoscedasticity, consequently, we introduce maximum likelihood method for parameter optimization.

本文主要在以下几个方面开展工作并获得了一些认知和结论：(1)通过分析样带区域内高寒草甸、高寒灌丛、沼泽化湿地和草原化高寒草甸四个通量观测站点草地生态系统总初级生产力变化特征，研究结果表明HBBT矮嵩草草甸生态系统植被光合作用能力较强，年GPP总量为652.2 gC/m~2，明显高于其他三种生态系统；通过利用"单塔日变化法"获得四站点通量观测数据随机误差，结果表明通量观测随机误差概率分布呈现尖峰厚尾的特征，与正态分布相比，更服从双边指数分布，进一步分析表明通量观测随机误差随环境变量(风速、温度和光合有效辐射)的变化而变化，这违背了普通最小二乘法进行生态过程模型参数优化正态分布且误差同质的假设，因此本研究中引入最大似然法进行生态过程模型参数优化。

This paper, aimed at the problem of drying aluminum fluoride trihydrate, studied the most possible binding format of crystal water, and hereby deduced the process of crystal water dehydration.

本论文针对三水氟化铝的干燥脱水问题，应用晶体结构理论、价键理论以及各种相关化学原理推测了三水氟化铝可能的结晶水结合形式，并据此推断了其结晶水的脱除过程：对氟化铝干燥特性进行了实验研究，研究了温度和升温速率对氟化铝干燥效果的影响：采用非等温TG-DTG法，对三水氟化铝进行了热分解行为和热分解动力学分析，进一步验证了三水氟化铝的脱水过程，并得出了其脱水和水解过程的动力学参数及方程。

Moreover, this paper makes an effort in incorporating theCosserat theory in the VCFEM for the elastic-plastic analysis of heterogeneous materialsbased on the PVP. The chapters are divided as follows: In Chapter 1, the author summarizes the study on the equivalent mechanics properties ofheterogeneous materials (including the development of the universal relationship which isirrelevant to the micro structure, the discussion of the limitations of the effective moduli, thecomputation of the effective properties of heterogeneous materials with the micromechanicsmethod and the FEM, and the equivalence of the heterogeneous micropolar materials) and thepresentation, the evolution, the corresponding numerical studies of the Cosserat model and itsapplications in engineering.

本文基于参数变分原理，构建了Cosserat体弹塑性有限元分析模型并用于求解应力集中和应变局部化问题；利用Voronoi有限元法提出了适用于非均质材料宏观弹塑性性能计算的参数二次规划算法；进一步将Cosserat模型应用到Voronoi有限元法中，提出了基于Cosserat理论的Voronoi杂交有限元法，并采用参数变分原理进行新模型的分析计算。

A multi-distance measurements method is employed in this paper. A single parameter fitting method and a double parameters (reduced scattering coefficient and amplitude factor) fitting method on the basis of the least square Newton fitting algorithm is used to derive the optical parameters respectively. For the finite-thickness homogenous tissue, it can be concluded that the rest terms in expressions of diffusion reflectance and transmittance for the corresponding tissue geometries that subtract the exponential term contained source-detector distance depend on the detected position weakly.

在多程测量的基础上，使用单参数最小二乘牛顿法拟合方法和双参数（约化散射系数、幅度因子）最小二乘牛顿法拟合方法，得到有限厚均匀组织的反射率分布和透射率分布公式中除去包含测量位置的指数项的其它部分对测量位置皆具有弱依赖性的结论，并对拟合结果进行了分析讨论；而对于有限厚平板状双层组织，可根据对反射测量结果及透射测量结果进行拟合所得的约化散射系数间的差异及常数因子的正负判断双层组织的可能结构分布。

This parameter canaccurately describe the degree of concentration of vibratory energy of the systemmodal shape in quantity. Using this parameter, the effects of mistuning on thelocalization of system modal shapes for various orders are studied. The reasons of themodal localization phenomenon are analyzed by the perturbation method.

利用所提出的模态局部化参数，研究了失谐对叶盘系统各阶模态局部化程度的影响规律，并利用摄动法对失谐所导致的模态局部化现象进行了分析；同时还发现，失谐叶盘系统的某些中间阶模态的局部化参数值在弱耦合区域的特定位置会产生奇异的突变现象，而这种突变现象是用摄动法难以解释的，并且可能会对失谐叶盘系统的振动稳定性产生重要影响。

The three dimension mechanics model of transmission shaft was established based on CBR with parametric technology.

采用参数化式实例推理法建立了传动轴三维力学分析模型。

In addition to commercial professional design tools such as SolidWorks and CorelDRAW , the students will be introduced to a new design environment where the objects in the design can be parameterized algorithmically.

除了商业专用设计工具如SolidWorks 和 CorelDRAW ，将介绍给学生们一种新的设计环境来把设计的物体用演算法进行参数化。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。