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去甲肾上腺素

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Methods The constriction induced by norepinephine (NE, 10-8-10-4 mol/ L) and diastole induced by acetylcholine (Ach, 10-8 -10-4 mol/ L) in thoracic aortic ring with angiosteosis induced by vitamin D3 plus nicotine in rats were recorded by BL-Newcentrary multichannel physiologic recorder.

维生素D3(VitD3)和尼古丁诱导大鼠血管钙化模型,通过BL-Newcentrary型多导生理记录仪,观察钙化大鼠离体胸主动脉环对去甲肾上腺素(norepinephine,NE)(10-8~10-4mol/L)和乙酰胆碱(acetylcholine,ACh)(10-8~10-4mol/L)引起的收缩和舒张反应。

The dilative effects of acetylcholine on rat aorta precontracted with NE 0.62 μmol/L were investigated to reflect the changes of dilative functions.

去甲肾上腺素诱发大鼠离体主动脉环的收缩,反映收缩功能的变化,主动脉环以0.62 μmol/L NE预收缩后用乙酰胆碱舒张对抗,反映舒张功能的变化。

METHODS: Cultured rat cardiomyocytes were induced to be hypertrophy by angiotensin Ⅱ and norepinephrine. Glucose oxidation rate, glucolysis rate and fatty acid oxidation rate were determined by liquid scintillation counting, and cell apoptosis was detected by TUNEL.

应用血管紧张素Ⅱ(AngⅡ, 0.1mol/L)+去甲肾上腺素(NE 1mol/L)诱导培养大鼠心肌细胞肥大,以同位素液闪计数法测定葡萄糖有氧氧化率、葡萄糖酵解率和脂肪酸有氧氧化率,TUNEL法测定细胞凋亡。

MB (10 μ mol/L), an inhibitor of GC, not only blocked completely the relaxation of HIMA, but also enhanced the vascular contraction induced by norepinephrine.

MB是GC的抑制剂, 10 μ mol/L的MB不但使VNP舒张HIMA的作用完全消失,而且可增强HIMA对去甲肾上腺素产生的收缩反应。

Results At 2 h after damage in cerebral cortex 5-hydroxyindolecetic acid (5-HIAA) elevated remarkably; At 8 h after da-mage 5-hydroxytryptamine (5-HT), homovanillic acid elevated; but there was no obvious change on norepinephrine and 3,4-dihydroxyphenyl acetic acid.

结果 大脑皮质运动区在损伤后2小时5-羟吲哚乙酸(5-HIAA〕明显升高;8小时后5-羟色胺(5-HT)、高香草酸升高;去甲肾上腺素及3、4-双羟苯乙酸变化不明显。

Hours later,these mice were decapitated,and the striatums were isolated from thebrains. The levels of dopamine, serotonin ( 5-HT ), homovanillic acid, 5-hydroxyindoleacetic acid ( 5-HIAA ) andnorepinephrinein the striatum were measured by high-performance liquid chromatography with electrochemical detection.

给3组小鼠分别喂食Dieldrin 50 mg·kg-1体重、Dieldrin 40 mg·kg-1体重和等量的生理盐水,3 h后处死小鼠,取纹状体匀浆用高效液相色谱-电化学检测法测定纹状体中多巴胺、5-羟色胺(5-HT)、高香草酸、5-羟基吲哚乙酸(5-HIAA)和去甲肾上腺素的含量。

The role of dopamine deficiency in depression is suggested by the frequency of depression in patients with Parkinson's disease and the effect of reserpine, which depletes serotonin, norepinephrine, and dopamine, causing a hypoactive state in animals.

抑郁症多巴胺不足的角色,从帕金森病人抑郁频繁中得到提示,利血平有效,帕金森病消耗了 5-羟色胺,去甲肾上腺素和多巴胺,动物引起活动减退的情状。

Objective To analyse the vasodilative mechanism of isocorydine, its effects on the increasing of the cytosolic free Ca 2+ level ([Ca 2+ ]i) induced by noradrenaline and high potassium in the blood vessel smooth muscle cells were investigated.

目的 观察扩血管药异紫堇啡碱对去甲肾上腺素和高钾所致血管平滑肌细胞内游离钙浓度([Ca2 + ]i)增高的影响,分析该药扩血管作用的原理。

Objective To analyse the antiarrhythmic mechanism of isocorydine,its effects on the increasing of the cytosolic free Ca 2+ level ([Ca 2+ ] i) induced by noradrenaline and high potassium in the cultural newborn rat beart cells were investigated.

目的 观察异紫堇啡碱对去甲肾上腺素和高钾所致培养乳鼠心肌细胞内游离钙浓度([Ca2 + ]i)增高的影响,初步分析该药心脏效应的作用原理。

In the present study, the effects of chloride channels blockers,(Niflumic acid,NFA;IAA-94;DIDS) on EJP were explored in guinea pigs, using intracellular recording techniques on acute isolated spiral modiolar artery.

本实验运用细胞内微电极记录技术,在豚鼠耳蜗螺旋动脉(spiral modiolar artery, SMA)离体标本上,研究氯通道阻断剂(Niflumic acid, NFA; IAA-94; DIDS )对去甲肾上腺素引起SMA平滑肌细胞的反应和平滑肌细胞EJP的影响。

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