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Objective Consequently, by constructing the pcDNA3-HA-hdacl, a HDAC1 eukaryotic expression vector, we were to study the interaction between HDAC1 and ERa and ERB in vitro and the effects of HDAC1 on the ERa and ERB at the protein level. So we can partly reveal the multiplication, differentiation and cancerization of lacteal gland cells.

目的 本文意在通过构建可在真核细胞中表达的重组质粒pcDNA3-HA-hdacl,研究组蛋白去乙酰化酶1(HDAC1)和雌激素受体ERα和ERβ在体外的相互结合作用,以及HDAC1对ERα和ERβ蛋白水平的影响规律,从而在一定角度揭示乳腺细胞的增殖、分化和癌变的过程,为更好地寻找治疗癌症的药物靶标打下基础。

Using a technique called nuclear transfer, technicians in the lab, Bill Ritchie and Karen Mycock, laboriously removed the DNA from 430 ewes' eggs, and inserted into 277 of these the genetic material from mammary epithelial cells.

实验室的技术人员Bill Ritchie和Karen Mycock运用一种称为核移植的技术艰难地把430个绵羊卵子的遗传物质取了出来,然后把源于乳腺上皮细胞的遗传物质移植到其中的277个中去。

The croaked Black Metal narrative is carried on the shields of the twin guitar attack, I抎 point to early SETH for how they sound, there is the warmth in tone on one of the guitars, something that the French band employed, however the other guitar is more incisive and has that touch of ice. There is an audible bass which provides some depth for the trebly guitars to race above and there is some fine clatter-tat-tat blasting from the skins department. Tracks like 揊rom My Throne OF Winter?are a cavalry charge into the soft flank of the enemy, the pace letting up from time to time as they breach a line of defence. All of the Metal tracks on the album benefit from this mix of breakneck speed and more mid paced sections. The production is typically lo-fi but as usual that is part of the appeal, there is no point recounting tales of past Pagan glories if you have a crisp digital production to spoil the ambience.The 揚rologue?and 揈pilogue?

而最吸引耳朵的还是尖叫部分,而且我敢打赌你以前从未在碾核音乐里听过这种嗓音,但我很难用合适的语言给你形容出来那究竟是怎样一种动静,粗略一点说它就像是受到惊吓的女人所发出的尖利声音,这样一来可能会让大家把他们和INTESTINAL DISGORGE混淆,那么再补充一句,主唱发出的声音并不是一个单音,那样未免就太枯燥无味了,而是有着跳跃性的节奏,我的能力只能形容到此,具体还要大家自己去体会了,而最令人不可思议的是主唱一人包揽了这两种唱腔,而这两种嗓音之间就像是天与地的差别,如果可能的话我还真想研究一下这位仁兄嗓子的构造。

Long hair, leather jacket, hole of jeans ……BE also, also not BE; Guitar, the shell department, drum ……BE also, also not BE; Elvis Presley, The Beatles, Bob Dylan, Nirvana ……BE also, also not BE;The impulse of young freedom, hormone, leave through the Pan way ……BE also, also not BE;Rhythm, lyrics, melody, dream, reality, felling, wild, believe in, strength, cut up rough ……BE also, also not BE;…… In fact these related association of thoughts be mutually just some forms, for the real rock'n roll culture, for hide to hide under these"external appearance"s of"pit", whether you has interest to understand or not?

长头发、皮夹克、破了洞的牛仔裤……也是,也不是;吉他、贝司、鼓……也是,也不是; Elvis Presley、The Beatles、Bob Dylan、Nirvana……也是,也不是;年轻的自由、荷尔蒙的冲动、离经叛道……也是,也不是;节奏、歌词、旋律、梦想、真实、感觉、狂野、信仰、力量、愤怒……也是,也不是;……其实这些相关的联想只是一些表相,对于真正的摇滚文化,对于遮藏在这些&皮相&之下的&核&,你是否有兴趣去了解呢?

For a historical example, Margulis suggests her own studies on the symbiotic nature of nucleated cells.

而如果要提供一个历史上的例子的话,Margulis的建议是我们可以去看看她自己关于有核细胞的共生本性所作的研究。

Stabilized, hypophosphorylated β-catenin translocates to the nucleus, where it interacts with transcription factors of the TCF/LEF-1 family, leading to the increased expression of genes, such as c-myc and cyclin D1

那么,药物的作用有以下几个可能性:2。药物促进或抑制catenin的核转位,但不影响其磷酸化程度3。药物可直接磷酸化catenin或直接使其去磷酸化,即具有磷酸激酶或磷酸酶的作用。

It's not that the sight of target is unclear but that he must shoot the arrow into a particular strand of wind among the gusts blow in this area so the wind could bring the arrow to hit the snake stick.

这次的困难跟射击魔核完全不同,这次他并不是看不清楚目标,而是他必须把箭射到四周吹刮不定的旋风间的其中一股,才能让风带著箭击中蛇杖,如果射错,箭就会不知被风吹到哪里去了—所以他这次同样箭在弦上,却迟迟未能射出;过了片刻,小翊大叫起来

The conception,main feature,foundation stone and research area of molecular nuclear medicinemolecular recognition as rationale, radioisotope labeling as tracer, we can explore the vital phenomena and disease take place from molecular level and give ,meanwhiles, giving a correctly diagnose and therapy of disease.

分子核医学的概念(以分子识别作为理论基础,利用放射性核素标记的示踪剂,从分子水平去认识生命现象和疾病发生、发展的规律,从而诊断与治疗疾病的一门综合性的边缘性学科)、主要特点、理论的基石与研究领域

We are a nation of Christians and Muslims, Jews and Hindus -- and nonbelievers.

对於世界上那些散布冲突、或将自己社会的病态怪罪於西方的领袖:要知道你们的人民,会根据你的建设而非破坏去评核你。

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And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47:5 法老对约瑟说,你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法,同时,采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。

Hey Big Raven, The individual lies dont matter anymore - its ALL a tissue of lies in support of...

嘿大乌鸦,个别谎言的事不要再-其所有的组织的谎言,在支持。