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In addition, after stably expression of bFGF, the biological characteristics of BMSCs and bone marrow-derived osteoblasts were analyzed in the fields of morphology, proliferation, cell cycle, alkaline phosphatase, typeⅠ collagen and so on.

从形态、增殖特性和细胞周期、碱性磷酸酶、Ⅰ型胶原等方面分析稳定表达碱性成纤维细胞生长因子的骨髓间充质干细胞和骨髓源性成骨细胞生物学特性。

All 7 cases were characterized by deposition of dystrophic or psammatous calcifications accompanied with chronic inflammatory cells infiltration in the stroma. In some cases, there was formation of germinal centers.

特徵性形态学表现为在胶原化的纤维组织间可见散在的钙化灶或砂砾小体,间质内伴有多少不等的淋巴细胞和浆细胞浸润灶,部分病例中可见生发中心形成。

The up-regulation of the expression of MMP-9 perhaps takes part in the accrementition and reconstitution of mesenchymal fibers (Ⅰ-type collagen dominates in mesenchymal, IOD ratio ofⅠ/Ⅲchanged). MMP-9 can facilitate inflammatory cell infiltration, aggravate the development of CAM.

2MMP-9的增高可能参与了骨骼肌间质纤维增生及其构成的改变(Ⅰ和Ⅲ型增多,Ⅰ型胶原与Ⅲ型胶原比值增高),诱导炎性细胞浸润,加重慢性酒精中毒性肌病的发生发展。

One eye in patients was selected to do the tear film breakup time, Schirmer test and cornea fluorescein staining, and the expression of NFκB and TGFβ1 on bulbar conjunctiva endepidermis was detected by immunohistochemistry.

TGFβ1是多功能细胞因子,对上皮细胞具有较明显的抑制作用,对成纤维细胞及其他间叶组织来源的细胞均具有明显的刺激作用,表现为胶原合成增加,有利于组织修复及伤口愈合[3,4]。

Another six specimens of each group was obtained for biomechanical test at 8 weeks. RESULTS: There were no significant differences between control group and fibrin group. In bFGF group compared with control and fibrin groups, appearance of the angiogenesis, fibroblast proliferation and collagen production in the sheath, epitenon and parenchyma at repair site occurred earlier and were more in quantity, the gliding excursion of the tendon was shorter, and the work of flexion and the ultimate tensile strength of the tendon were greater.

结果:对照组与纤维蛋白封闭剂组间各项观测指标比较均无显著性差别,与对照组和纤维蛋白封闭剂组相比,bFGF组修复部位腱鞘、腱外膜及腱实质的新生血管形成、成纤维细胞增殖较好,胶原的分泌出现早,数量也较多;肌腱滑动距离较短,屈曲功和肌腱最大抗拉力较大。

Results Microscopically, the tumor cells were epithelioid or short spindled and special nests of tumor cells separated by arboring fibrovascular septa. Such morphological variants of CCSK as myxoid degeneration, microcysts formation and sclerosing pattern of extracellular hyalined collagen simulating osteoid were present in some regions.

结果 镜下见瘤细胞为上皮样或短梭形,被分枝状纤维血管间质分隔成巢团状,部分区域见黏液样变性微囊肿和细胞外胶原玻璃样变类似骨样组织的硬化型等形态变异。

Some evidence indicates that the combination of extrinsic, intrinsic and genetic factors all play a role to cause the disc degeneration, with a progressive decrease in proteoglycan content leading to dehydration of the nucleus pulposus, and Type Ⅰ collagen begins to appear in the matrix, the ratio between Type Ⅰ and Type Ⅱ increases. All these cause the swelling pressure, disc height and the disc load bearing ability decrease. The disc progressively herniate and cause radiculopathy and myelopathy.

内因、外因及遗传方面的诸多因素导致椎间盘逐步退变后,其实质就是基质中蛋白多糖的减少,含水量降低,Ⅰ型胶原出现在基质中,Ⅰ、Ⅱ型胶原的比例明显上升,髓核呈纤维样改变,导致椎间盘的膨胀压降低,承重能力下降,椎间高度降低,椎间盘承受的重力不能平均地向各方向传递,致使纤维环疲劳、破裂、髓核突出,造成脊髓或马尾神经受压,引起严重后果。

Objective To observe the ultrastructure of supra interspinous ligament of ankylosing spondilitis,to evaluate the role of fibroblasts in ossification of ligament,and to discuss if disorderly arrangement of collagen and sedimentation of calcium granule in AS are induced by fibroblasts.

目的 观察强直性脊柱炎棘上棘间韧带的超微结构和探讨成纤维细胞在韧带骨化中的作用。找出AS韧带中胶原紊乱排列和钙颗粒沉积是否由成纤维细胞活动引起。

In carcinomatous mucosa, immunoreaction of the carinomatous cell nest was negative, or only remnants of positively were seen at the site of the former membrane by collagen type Ⅳ.

结果 正常组织的基底膜呈现很强的Ⅳ型胶原抗体阳性反应,在基底膜形成较粗的环形染色带;Ⅲ型胶原抗体阳性反应在细胞外间质呈连续的细丝纤维样。

BACKGROUND: Basic fibroblast growth factor can accelerate the bone marrow mesenchymal stem cells proliferation and differentiation into nerve cells, which is considered as a mitogen of glial cells.

背景:碱性成纤维细胞生长因子可以促进骨髓间充质干细胞的增殖和向神经细胞方向分化,并被认为是胶质细胞的分裂原。

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