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Purpose To study the role of pulmonary macrophages in the collagen deposition of fibrotic interstital lung disease.

目的:探讨肺泡巨噬细胞在纤维性间质性肺病胶原纤维异常沉积中的作用。

The results showed:(1) MP polymerase chain reaction test showed positive results in the bronchoalveolar lavage fluid from all of the MP-infected rats (infectious group, n=4), while they were all negative in BALF from the control group (n=4,P<0.05) and from those rats both infected with MP and, at the same time, treated with erythromycin (treating group n=4,P<0.05). Bacterial cultures of the bronchial and lung tissue were negative in all three groups. Using transmission electron microscope the widened interalveolar septa with increased amount of collagen were found in the infectious group, while there were no obvious abnormalities in the other two groups.

结果显示:(1)感染组动物(n=4)支气管肺泡灌洗液肺炎支原体-PCR检测均为阳性,而对照组(n=4)和感染加红霉素治疗组动物(n=4)均为阴性(P<0.05);三组动物的支气管和肺组织常规细菌培养结果均为阴性;感染组动物透射电镜检查见肺泡间隔增宽,其中有较多胶原纤维堆积,其余两组则未见明显异常。

The intraretinal collagen fibrils penetrating the ILL and mixing with the cortical vitreous fibrils appears to underlie the slow adhesion of the vitreoretinal interface with aging.

随年龄增长来自视网膜内的胶原纤维逐渐穿透ILL与玻璃体皮质纤维缠绕结合,使基底部玻璃体视网膜界面粘连延伸。

RESULTS: The extract of Aml could reduce the abnormally high levels of ALT and AST. Examined by light microscope , the degeneration and necrosis level of hepatocytes and the distribution of collagen fibrosis were markedly increased in the model group. The pathological changes and the c ollagen fibrosis associated with hepatic fibrosis decreased significantly in the prophylactically treated groups.

结果: 蓍草提取物预防给药能降低 CCl 4所致大鼠血清中异常增高的 ALT 、 AST 含量,光镜下观察肝纤维化模型组大鼠肝细胞严重变性、坏死,胶原纤维明显增加,蓍草预防各组大鼠肝细胞病理损伤得到明显改善。

Sixty six male Sprague-Dawley rats were randomly divided into control group,and 5 model hepatic fibrosis groups perfused alcoholic,maize oil and pyrazole for 2 weeks,4 weeks,8 weeks, 12 weeks and 16 weeks (11 rats in each group) respect...

结果 与对照组比较,酒精灌胃 4周、8周、12周、16周组大鼠OPN、α SMA表达显著增强并且肝内胶原纤维含量显著增加。正常肝组织中几乎不表达OPN ,在酒精性肝纤维化大鼠模型的建立过程中,从第四周开始中央静脉。。。

Results:(1) In clinical pathology, swelling, denatured, even necrosis and putrescence could be picked out; Collagen fibers in tendon remarkedly swelled, and tissue structure disarranged, and collagen even ruptured, broken and dissolved; Obvious denature, apoptosis and necrosis could be found in tendon cells. There appeared to be a big accumulation of inflammatory cells.

结果 (1)临床病理组织学观察发现:肌腱组织肿胀、变性、甚者坏死、腐败;肌腱内胶原纤维肿胀明显、组织结构紊乱,失去正常排列,甚者出现胶原断裂、破碎、溶解等现象;腱细胞可见明显的变性、凋亡和坏死;病变部位可见大量炎性细胞聚集。

Fig 3Lots of rough endoplasmic reticula, mitochondrid an d collagen in the cytoplasm of fibroblast in control group

图3对照组的瘢痕成纤维细胞粗面内质网、线粒体丰富,形态结构正常,周围胶原纤维较多TEM×5200

Fig 4 Few of rough endoplasmic reticula, mitochondrid and co llagen can be seen in the cytoplasm of fibroblast, the ribosome of rER is degran ulated, the nucleous is abnormal, there are a lot of granule (maybe the antisens e oligodeoxynucleotide) in the cytoplasm TEM×5200

图4反义核酸组的瘢痕成纤维细胞粗面内质网较少、有脱颗粒现象,线粒体少,胞核畸形,胞内有吞噬颗粒,细胞周围胶原纤维较少TEM×5200

It suggests that the supraspinous ligaments in the patients with ossification of the ligament flavum also have an obvious tendency of ossification.

结果:胸椎黄韧带骨化症患者棘上韧带内胶原纤维增生、肿胀,出现了大量的纤维软骨细胞,甲苯胺蓝染色呈强异染性。

The effects of gastrodine on the expression of glial fibrillary acidic protein, the transuding amount of lactic dehydrogenase, and the activity of nitric oxide synthase in cultured astrocytes of young rats with lesions caused by simulated cerebral ischemia and reperfusion, were determined in this experiment.

观察天麻素对脑缺血再灌注损伤星形胶质细胞胶原纤维酸性蛋白表达、乳酸脱氢酶漏出量以及一氧化氮合成酶活性的影响。结果:天麻素大、小剂量组GFAP纤维样改变减轻,强阳性反应细胞数减少;LDH漏出量下降;NOS活性减弱。

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Finally, according to market conditions and market products this article paper analyzes the trends in the development of camera technology, and designs a color night vision camera.

最后根据市场情况和市面上产品的情况分析了摄像机技术的发展趋势,并设计了一款彩色夜视摄像机。

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