原发病

Results Of the 532 cases,238 (44.7%) were involved in both the cutis and mucosae.351 of them (66.0%) were infected dermatologically,164 (30.8%) developed venereal diseases and 47 cases (8.8%) were complicated wit...

结果在发病部位中同时累及皮肤及黏膜的238例(44.7%)；患皮肤病351例(66.0%)，性病164例(30.8%)；47例(8.8%)患者合并有系统性疾病；在315例接受病原体检查的患者中，以支原体、念珠菌及衣原体的检出率较高，分别为17.4%，14.3%，13.0%。

Small intestinal biopsies showed subepithelial collagen deposition with varying degrees of villous atrophy and varying numbers of intraepithelial lymphocytes. Four patients had previous biopsies showing enteropathic changes without collagen deposition. Seven cases were associated with collagenous colitis and 1 also had features of lymphocytic colitis. Three patients also had collagen deposition in gastric biopsies. One case was associated with lymphocytic gastritis. Celiac disease (CD, gluten-sensitive enteropathy) was documented in 4 patients. Five patients made a clinical improvement with combinations of a gluten-free diet and immunosuppressive therapy. Two patients died of complications of malnutrition and 1 of another illness. Clonal T-cell populations were identified in 5 of 6 cases tested. Four of these patients improved clinically after treatment but 1 has died. Collagenous sprue evolved on a background of CD in 4 cases. There was no history of CD in others and these cases may be the result of a biologic insult other than gluten sensitivity.

小肠活检表现为上皮下胶原沉积，绒毛萎缩程度不一，上皮内淋巴细胞浸润数量不等。4例患者以往曾做过活检，表现为其他肠病改变，并没有胶原沉积。7例患者合并胶原性结肠炎，且1例还有淋巴细胞性结肠炎的特征。3例患者胃活检也发现有胶原沉积。1例患者合并淋巴细胞性胃炎。4例患者有乳糜泻（CD，谷蛋白敏感性肠病）病史。5例患者经无麸质饮食和免疫抑制治疗后，临床症状有所改善。2例患者因营养不良合并另一种疾病而死亡。6例患者做了T细胞受体基因重排，其中5例发现有克隆性T细胞群，这5例中有4例治疗后临床症状加重，且1例死亡。4例患者在CD的基础上病发胶原性口炎性腹泻；其余患者无CD病史，他们的发病也许是生物源性损害，而非谷蛋白敏感。

To some degree, this study revealed the relationship between ossein and bone miner and the important preventive and therapeutic effects of ossein on OP. It provides theoretical and experimental basis for the research and development of effective prescriptions to cure OP. Limited by the actual experimental situation, we only did some study on the synthesis and content of type Ⅰ collagen. Further study on the changes of decomposition and structure of type Ⅰ collagen are needed to be done.

本课题的研究，在一定程度上揭示了骨胶原纤维和矿物质之间互根互用的辨证关系，及Ⅰ型胶原在骨质疏松症的发病和治疗中所起的重要作用，并为开发研制治疗本病的有效中药复方提供了理论和实验依据，但由于条件所限，本研究仅就Ⅰ型胶原的合成及其含量变化做了初步观察，而本病中骨胶原纤维的分解代谢及其结构的改变，尚待进一步探讨。

The results showed:among the 7 isolates, five isolates of HY3、GY1－3、ZJ1－1、HP1、FC3 had same colony shape, irregular shape, liquidlike, slimy, opacity with smooth surface;the other two isolates had same shape, irregular shape, dry, opacity with coarse surface. By inoculating eucalyptus with the 7 isolates, the plants were infected apparently, and the young plants of eucalyptus in control experiment with tap water were not infected. By cultivating eucalyptus cuttings with the bacterial suspensions without EPS, the incidence of disease was very distinct,but compared with the former bacteria suspension,the incidence of disease has decreased at different degrees. By screening out two isolates of strong pathogenicity and two isolates of weak pathogenicity from the 7 isolates,making the bacterial suspensions with them to inoculate the young plants of eucalyptus, two treatments of cutlings and ramets with rats were set with 5 repetitions in every treatment, the results of data analysis showed: for the cutlings, the bacterial contents in upper and middle parts、upper and lower had significant difference;for ramets with roots, the bacterial contents in upper, middle parts, lower had significant difference between each other; For both the cutlings and ramets with roof, the bacterial contents in xylem and phloem had significant difference. The interaction between vertical and horizontal parts for the bacterial content had significant difference. For the two isolates of HY3 and 93B which were screened out at last,their activities of the cellulase were: 1.955ug/ and 1.288ug/ respectively, and had significant difference; the activities of pectase were: 1.325 ug/and 1.24ug/ respectively, and had no significant difference. The content of EPS extracted from the two isolates of HY3 and 93B was very different: 7.08x10-8ug/cell and 5.17x10-8ug/cell.

结果显示：7个菌株中，其中5个菌株HY3、GY1－3、ZJ1－1、HP1、FC3的菌落形态相同：不规则形状、流体、粘性、不透明、表面光滑；另外2个菌株93B、GN1菌落形态相同：不规则形状、干燥、不透明、表面粗糙；用7个菌株接种剪根桉树苗，发病情况非常明显，而自来水对照实验中桉树苗却不发病；无EPS菌悬液培养桉树剪根苗，发病率也很明显，但是相比原菌液，则发病率有不同程度的下降；从7个菌株中间筛选出来2个强致病性菌株和2个弱致病性菌株，用它们配制菌悬液培养桉树苗，设置剪根和不剪根两个处理，每个处理设置五个重复，数据分析结果显示：对于剪根苗，上部和中部、上部和下部的含菌量有显著的差异，中部和下部含菌量差异不显著；带根苗，上部、中部、下部含菌量彼此之间差异显著；不管是剪根苗还是带根苗，木质部和韧皮部含菌量之间的差异都非常显著；上中下与木韧交互作用中，含菌量差异非常显著；最后筛选出来的强弱2个菌株HY3和93B，它们的纤维素酶活性分别为：1.955ug/和1.288ug/，具有显著的差别；果胶酶的活性分别为：1.325 ug/和1.24ug/，没有显著的差别，而且HY3和93B两个菌株细胞分泌的胞外多糖的含量差异很显著，分别为：7.08×10-8ug/cell和5.17×10-8ug/cell。

Pass observation of clinical curative effect, cure can enhance Chinese traditional medicine fitness, improve immune function, control allergic source, the upper respiratory tract relapses the symptom such as infection, have main effect to reducing blood in the urine, albuminuria, draft the root of remembranous milk vetch, Asian puccoon oneself, yuan grass of armour of ginseng, madder, 37 ginseng, plain hill, horsewhip, Bai Maogen, n/bot glossy privet child group waiting for medicine square, heat up detoxify with Yu Qing, invigorate the circulation of blood whitewashs Yu, cool blood filling kidney of hemostatic, method of treating yin deficiency by reinforcing body fluid and nourishing the blood administer a law, achieve the goal that administer thoroughly. 1 data and method 1 · 1 clinical data: 186 patients all are outpatient service case of illness, accord with Minica to concern the diagnostic standard of purpuric sex nephritis, among them the male 105, female 81, come on on average age 8~13 year old, time sees a doctor after coming on 3 months ~1 year, have direct allergen 86, have apparent infection 20, the others cause of disease is same.

通过临床疗效观察，中药治疗能增强身体素质，提高免疫功能，控制过敏源，上呼吸道反复感染等症状，对减少血尿、蛋白尿起到主要功能，自拟黄芪、紫草、元参、茜草、三七参、川山甲、马鞭草、白毛根、女贞子等药组方，用于清热解毒，活血化瘀、凉血止血、滋阴补肾等治法，达到标本兼治的目的。1资料和方法1·1临床资料：186例患者均为门诊病例，符合Minica有关紫癜性肾炎的诊断标准，其中男性105例，女性81例，平均发病年龄8~13岁，发病后就诊时间3个月~1年，有直接过敏原86例，有明显感染20例，其余病因相同。

deep vinous thrombosis, operation, fibrinogen, cholesterol, plasminogen, smoking are independent and important risk factors for VTE.

下肢深静脉血栓形成，手术，高纤维蛋白原，胆固醇，纤溶酶原，吸烟是肺栓塞的独立危险因素，肺栓塞发病与多种因素有关。

ConclusionDeep vinous thrombosis, operation, fibrinogen, cholesterol, plas-minogen, and smoking are independent and important risk factors for VTE.

结论下肢深静脉血栓形成、手术、高纤维蛋白原、胆固醇、纤溶酶原、吸烟是肺栓塞的独立危险因素，肺栓塞发病与因素有关。

Materials and methods: The lung preparation of 6 SARS death patient (died in 9,14,20,29,33,38d) and 6 macaque model (killed in 7,12,14,14, 32, 35d)were objects. Pathological changes, collagen fibers, lattice fibers, elastic fibers, collagen I and III in lungs and fine structure changes were studied by routine H.E dyeing, trigeminy dyeing, trinitrophenol- sirius red staining and polarization microscope, electron microscope and image analysis. Expression of Vimentin、 TGFβ_1、 TNF α、 IL-1β and MMP-2 were detected by immunohistochemistry.Results:1. Pathological changes of SARS death patient.

材料与方法：以6例SARS死亡患者(分别于发病后9、14、20、29、33、38d死亡)和6只猕猴实验模型(分别于染毒后7、12、14、14、32、35d活杀取材)肺标本为对象，应用H.E染色、三联染色、苦味酸-天狼猩红-偏振光法、电镜和图像分析等技术，对比性观察SARS肺组织病理变化和纤维化的病理过程、胶原纤维、网状纤维和弹力纤维的变化特点、Ⅰ型与Ⅲ型胶原纤维的数量和分布规律，旨在探讨SARS肺纤维化的病变经历过程及特点；利用免疫组织化学和形态计量学技术检测SARS死亡患者肺脏的Vimentin、TGFβ_1、TNFα、IL-1β和MMP-2等与炎症反应和纤维化相关活性因子，探讨其发病机制。

The most likely mechanism of Krukenberg tumor development is via retrograde lymphatic spreading from gastrointestinal cancers involving the stomach, colorectum, appendix, gall bladder/bile duct, small intestine and pancreas, with peak incidence occurring in premenopausal women from 30 to 49 years old.

Krukenberg瘤最可能的发病机制是胃肠道癌的逆行淋巴道转移，常见的原发瘤部位依次为胃、结直肠、阑尾、胆囊／胆管、小肠、胰腺，30-49岁绝经前妇女发病最多。

Reveal the characteristics and regular pattern of its epidemic.①Investigated the epidemiological history of 448 clinical confirmed SARS cases, drawing the map of coming places of primary cases and whereabouts of the secondary cases, clarify the reasons of SARS inputting and spreading.②Exploring transmission relationship between cases by drawing the chain-map and learning the main transmission process.③Selecting the chain-cases with the exact onset and contact time to calculating the average incubation of same generation cases on different transmission chains and the average incubation of different generation cases on same transmission chain, Calculating the incubation median, the fifth percentile and the ninety-fifth percentile of the incubation of the observed cases.④Analyzing the timeliness of admission and the treating condition through the statistical calculation of the onset time, the admission time, the hospitalization time as well as the diagnostic time of the suspect and clinical confirmed cases.

调查全省448例SARS临床确诊病例的流行病学史，绘制全省输入SARS原代病例的主要来源以及引起传播后被感染者的去向图，阐明SARS病例的输入与扩散原因；②用传播链图分析传播关系，了解SARS的主要传播过程；③选择SARS原代病例与续发病例接触日期、发病日期明确而完整的传播链病例计算不同传播链同一代之间以及同一传播链不同代之间的平均潜伏期，并计算观察病例潜伏期的中位数以及第5、第95百分位数，确定SARS的最短潜伏期和最长潜伏期；④对患者发病、就诊、住院时间以及医院诊断为SARS可疑病例、临床确诊病例的时间进行统计，分析SARS就诊的及时性以及临床诊治情况；⑤计算不同接触方式、关系密切程度传播SARS的危险度，筛选形成传播的主要危险因素；⑥检测不同人群和同一人群不同时间的SARS血清抗体，了解抗体的阳转时间和持续时间。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。