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Objective To explore the effect of Znic Protoporphyrin and its mechanism on the hemeoxygenase -1 (HO-1) mRNA expression in brain tissue of developing rat with febrile convulsion.

目的 探讨锌原卟啉对高热惊厥发育期大鼠血红素氧合酶-1 mRNA表达的影响及作用机制。

This study examined the effect of the HO inhibitor zinc protoporphyrin Ⅸ on the expression of neuronal NOS mRNA and protein and also the plasma NO content in rats with recurrent FS. The goal was to study the effect of CO on the NOS/NO system.

本研究观察HO抑制剂锌原卟啉Ⅸ对FS大鼠海马神经元型NOSmRNA和蛋白表达及NO含量的影响,以探讨CO对NOS/NO体系的调节作用。

Methods The hemin and zine protoporphyrin-Ⅸ were added in the cultured endothelial cells to induce and inhibit the expression of HO-1, respectively.

体外培养人脐静脉内皮细胞,用氯血红素和原卟啉锌,以诱导和阻断HO-1的表达。

Methods A total of 60 rats were employed and equally divided into 5 groups, i.e. control, HPH, hemin, Tin Protoporphyrin and low concentration CO groups.

60只Wistar大鼠随机分为5组:正常对照组;低氧肺动脉高压组;血晶素组;锡原卟啉组;低浓度CO组;每组12只。

Abstract] Objective To study the effect of zinc protoporphyrin,an inhibitor of heme oxygenase-1(HO-1),on pathological and pathophysiologic changes of rat pulmonary fibrosis induced by bleomycin,and to investigate the role of Znpp in the pathogenesis of pulmonary fibrosis.

目的 观察血红素加氧酶-1(HO-1)抑制剂锌原卟啉对博莱霉素致大鼠肺纤维化模型病理和病理生理改变的影响,探讨Znpp在BLM诱导肺纤维化发病中的作用。

To explore the feasibility of using serum zinc protoporphyrin as the screening index in the occupational sanitary surveillance for lead-exposed workers.

目的 探讨铅接触者职业健康监护中血锌原卟啉作为筛选指标的可行性。

To investigate the fluorescence dynamic change of protoporphyrin IX in bladder carcinoma cell induced by 5-ALA and the influence of 5-ALA concentration and pH on fluorescence of PpIX. 2. To discuss the biodistribution and express of PpIX in bladder wall of different lesions by method of instilling of 5-ALA into bladder cavity. 3. To discuss the clinical value of the fluorescence diagnosis in early detection of bladder cancer and the radicality of bladder tumor resection under fluorescence cystoscopy.

本研究目的:1了解5-ALA诱导膀胱癌细胞内生原卟啉IX荧光随时间的动力学变化及5-ALA的浓度、pH值对产生PpIX荧光的影响。2通过膀胱灌注5-ALA探讨其所诱导内生PpIX荧光在膀胱上皮中分布及不同病变表达上的差异。3探讨5-ALA诱导荧光膀胱镜检对发现早期膀胱癌的临床应用价值及在荧光膀胱镜下膀胱肿瘤电切治疗的彻底性。

BACKGROUND: Polymorphic light eruption and erythropoietic protoporphyria have been demonstrated to have a moderate and large impact on the quality of life of patients, respectively.

背景:研究证实多形性光疹对患者生活质量有着中度影响,红细胞生成性原卟啉病对患者QoL有较大影响。

Objective To investigate the FECH gene mutation in a Chinese family with erythropoietic protoporphyria, to explore the relationship between gene mutation and clinical manifestations so as to establish a basis for the genetic diagnosis and treatment of erythropoietic protoporphyria.

目的 对一红细胞生成性原卟啉病家系进行基因突变研究,探讨基因突变与临床表现的关系,为进一步开展基因诊断和基因治疗奠定基础。

The pyridine hemochrome spectrum indicated the presence of protoheme Ⅸ as the prosthetic group.

吡啶血色素光谱显示了酶分子以原卟啉Ⅸ作为辅基。

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