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Results: There is a significant difference between the levels of Hb、SF、 FEP of model groups and normal group. The syndrome of every treatment groups is much better than physiological saline solution group, and recover gradually. The Hb、 SF、 FEP and IL-2、 IL-6 were recover gradually. But the improvement of AS two solstices pill add chalybeate group is comparatively obvious. Conclusions: AS two solstices pill add chalybeate has obvious therapeutic action on IDA model rats.

结果:造模后,各组大鼠Hb、血清铁蛋白、红细胞游离原卟啉与正常对照有明显差异,经治疗后症状表现上明显较模型NS对照组好,且逐渐恢复,Hb、血清铁蛋白、红细胞游离原卟啉、血清IL-2、IL-6水平逐渐恢复正常,其中以加味二至丸加铁剂组和当归补血汤加铁剂组最为明显。

Benzoxazine compounds are one kind of highly active protoporhyrinogen oxidase inhibitors. These compounds can effectively control both monocotyledon weeds and dicotyledon weeds at lower dosage. The action mechanism is similar to p-nitro-o-substituted diphenylethers. They can result weeds albinism and decolorization, which are very important albinism herbicide.

苯并噁嗪类化合物是一类高活性的原卟啉原氧化酶抑制剂,低剂量可有效地防除禾本科与阔叶杂草,其作用机理和对硝基邻位取代的二苯醚类似,它们造成白化或脱色,是白化除草剂中较重要的种类,其活性远超过二苯醚除草剂,是目前化学农药研究领域的热点。

The effectiveness of hematin and protoporphyrin IX as photosensitizes in singlet oxygen(1O2)generation was determined and at the same time the influence of different light wavelength on them was studied.

研究了肌红蛋白的组成成分血红素和原卟啉的光敏能力,同时分析了不同波长光的照射下血红素和原卟啉对猪肉脂肪氧化的影响。

The content determination of protoporphyrin IX shows great clinic significance for preventing and curing disease related with porphyrin.

原卟啉IX是血红素的重要组成部分,其含量的测定对卟啉类疾病的预防和治疗具有重要的临床意义。

Methods A rat model of myocardial ischemia/reperfusion injury was established by treating with HO-1 inducer cobalt protoporphyrinor inhibitor zinc protoporphyrin.

采用HO-1的诱导剂钴原卟啉和抑制剂锌原卟啉分别进行干预处理后,建立大鼠的心肌缺血/再灌注损伤模型。

The pure isomers 3-(1-hydroxyethyl)-8-vinyldeuteroporphyrin Ⅸ and 3-vinyl-8-(1-hydroxyethyl)deuteroporphyrin Ⅸ were obtained from protoporphyrin Ⅸ dimethyl ester.Starting from these two acetylating compounds,eight new porphyrin derivatives were synthesized through an alkyloxy fission reaction.

原卟啉Ⅸ二甲酯为起始原料,合成并分离得到3-(1-羟乙基)-8-乙烯基次卟啉Ⅸ(Ⅱ1)和3-乙烯基-8-(1-羟乙基)次卟啉Ⅸ(Ⅱ2)二个异构体,两者分别经酰化后与醇进行烷氧裂解反应合成了8个全新的卟啉衍生物。

Results Based on clinical symptom and porphyrin levels, a diagnosis of erythropoietic protoporphyria was made in 3 family members.

结果 根据临床表现和卟啉测定结果,患者明确诊断为红细胞生成性原卟啉病。

The content of intermediates such as protochlorophyll,Mg protoporphyrinand protoporphyrin IXwere reduced and δ aminolevulinc acid and porphohilinogenwere markedly accumulated in albino seedlings of W1,which proved that there was a blockage in the formation of uroporphyrinogen or coproporphyrinogen during Chl biosynthesis under lower temperature.

白化苗中Chl生物合成的中间产物原叶绿素、镁原卟啉原卟啉IX含量减少,而δ氨基酮戊酸和胆色素原大量积累,证明突变体W1低温下Chl生物合成卟啉原形成部位受阻

The active conformation of protoporphyrinogen IX (substrate of protoporphyrinogen oxidase) has been established using the Distance Comparisons method. In this paper, four different conformational molecules of Protogen IX and crystal molecule of diphenylethers are analyzed by comparing their geometry parameters. The results show the lower energy active conformation from the DISCO model is more reasonable.

我们曾利用距离比较法确定了原卟啉原氧化酶的底物—原卟啉原IX的活性构象,本文从构象分析的角度对4种不同构象的原卟啉原IX分子与二苯醚类分子的晶体学构象进行了几何参数的比较和分析,结果进一步证实了距离比较法所确定的活性构象更为可靠。

In the reasonable drug molecular design,analyzing the conformations of the substrate without three-dimension structure and confirming its active conformation are very important to illustrate the spatial shape and active site of target enzyme. The active conformation of protoporphyrinogen IX substrate of protoporphyrinogen oxidase has been established using the Distance Comparisons DISCO method. In this paper, four different conformational molecules of Protogen IX and crystal molecule of diphenylethersAF are analyzed by comparing their geometry parameters. The results show the lower energy active conformation from the DISCO model is more reasonable.

在合理药物设计方法中,当靶标酶的三维结构未知时,对其底物进行构象分析,特别是确定其活性构象,对阐明靶标酶活性中心的空间形状和作用位点具有十分重要的意义我们曾利用距离比较法确定了原卟啉原氧化酶的底物—原卟啉原IX的活性构象,本文从构象分析的角度对4种不同构象的原卟啉原IX分子与二苯醚类分子的晶体学构象进行了几何参数的比较和分析,结果进一步证实了距离比较法所确定的活性构象更为可靠

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