卵泡

Our data support the notion that human follicle development can be achieved in vitro in a bio-engineered culture system.

结论我们的数据表明，人类卵泡在体外生物工程培养体系中是可以发育的，但仍需要更多的研究进一步揭示体外培养卵泡是否获得充分大小的卵母细胞，而且卵母细胞是否有能力恢复减数分裂和受精。

The compound of neem oil have obvious effect of anti-fertility, the mechanism of its anti-fertility effect of compound of neem oil could be attributed to the metabolization of oocyte, and the obstruction of metabolization may cause the oocyte denaturalize and necrotize.

印楝油复合物具有明显的抗生育作用，其作用机制一方面可能是通过影响卵泡细胞的代谢过程，导致代谢障碍而致使卵泡细胞发生变性、坏死；另一方面，可能与局部细胞免疫介导有关。

both a high level of testosterone and a more number of follicle can increase the synthesis of estrogen after the ovary excitation test.the sensitivity of foh ovary to the ovary excitation test is higher when the follicle number is more.

雄激素水平和卵泡数量均可影响卵巢兴奋试验后e2的合成，且具有协同作用，卵泡数量较多的患者对卵巢兴奋试验更加敏感。多囊卵巢综合征；功能性卵巢高雄；雌激素

Granulosa cell apoptosis was a physiological phenomenon in follicles, and with the progress of atresia, the percentage of apoptotic granulose cells increased significantly.

颗粒细胞凋亡是卵泡中生理现象，随着卵泡闭锁凋亡颗粒细胞的比例增多。

Then in accordance with the development of follicle size, 3 days on the 18th and had a follicle monitoring, size 17 * 14 leucorrhea

然后根据卵泡的发育大小，3天后18号又进行了一次卵泡监测，大小为17*14

Follicular development is a complex procedure, which includes follicular initiation, recruitment, selection, dominance, ovulation, and luteinization.

卵巢卵泡发育是个十分复杂的过程，经历卵泡发育的启始、募集、选择、优势化、排卵和黄体化等过程。

Bone morphogenetic protein 15 is only expressed in oocytes. Oocyte-specific BMP-15 might promote follicle growth in vivo, while preventing premature luteinization.

骨形态发生蛋白 15(BMP-15)基因在卵母细胞中特异表达，对卵泡的生长发育起着重要的调节功能，具有推动卵泡生长，阻止黄体早熟的作用。

Methods Immature female Kunming mice were treated with Pregnant Mare Serum Gonadotropin to induce the follicular development, with PMSG/human Chorionic Gonadotropin to promote the ovulation and luteinization.

性成熟前小鼠用孕马血清促性腺激素刺激卵泡生长，用绒毛膜促性腺激素刺激卵泡排卵及向黄体转化。

Though it was slower in the frozen-thawed embryo transfer group than that of the fresh embryo transfer group, there were no significant differences in estrous cycle between experimental group and normal control group. The grafts were taken out and observed on day 63 after transplantation, rich blood vessels were formed on the cover of the graft, arterioles and venules could be seen under microscope. Histological examination of graft revealed that transplanted fetal ovary contained follicles in different developing stages, vesicula graafianae and corpus luteum were formed, and the morphous of graft was no obvious differences to normal ovaries.

冷冻移植组大鼠恢复动情周期虽稍短于新鲜移植组，但差异并无统计学意义。63 d后取出移植物观察，见移植物色泽红润，表面有丰富的血管形成，镜下见卵巢内有大量的小动脉和小静脉；移植物组织学检查发现卵泡的发育，光镜下可见不同发育阶段的卵泡，有成熟卵泡和黄体形成，形态与正常卵巢无明显差别。

When aborted rats in group E were treated with the dose of 50 IU/g IFN-γ, expression of TNF-αin this group was compared with the other four groups, the results were as follows: Compared with group A, the nucleus pre-opticus medialis, nucleus pre-opticus mango celluaris, nucleus periventricularis hypothalami, nucleus ventromedialis hypothalami, nucleus dorsomedialis hypothalami, nucleus arcuatus hypothalami and pars intermedia had a highly expression of TNF-α, in the other nuclei of hypothalamus, neurohypophsis and adenohypophysis, the change was not significantly, the expression of TNF-αin follicle and corpus luteum were decreased distinctly, the variation in uterus was slight and no difference was exsited; Compared with group B, the expression of TNF-αin nucleus nucleus lateralis hypothalami, nucleus ventromedialis hypothalami, nucleus arcuatus hypothalami, adenohypophysis and uterus presented a remarkable enhancement, conversely, the TNF-αexpression in the nucleus pre-opticus medialis, nucleus pre-opticus suprachiasmaticus, nucleus supra-opticus, nucleus pre-opticus mango celluaris, nucleus periventricularis hypothalami, nucleus paraventricularis hypothalami, neurohypophsis, follicle and corpus luteum had been significantly decreased; Compared with group C, the nucleus pre-opticus medialis, nucleus ventromedialis hypothalami, nucleus dorsomedialis hypothalami, nucleus arcuatus hypothalami, adenohypophysis, pars intermedia and uterus had upregulated the expression of TNF-α, however, it was decreased in the nucleus periventricularis hypothalami and corpus luteum; When compared with group D, the expression of TNF-αin nucleus lateralis hypothalami, nucleus dorsomedialis hypothalami, nucleus ventromedialis hypothalami, pituitary, follicle and ovary stroma were obviously enhanced, while in the nucleus supra-opticus and nucleus arcuatus hypothalami, the situation was definitely opposite, in the other parts, the change was not significant.

外源腹腔注射50 IU/g IFN-γ后，同A组相比：E组TNF-α免疫阳性产物在下丘脑视前内侧核、视前大细胞核、室周核、腹内侧核、背内侧核、弓状核、垂体中间部显著增高，在下丘脑其它核团、神经垂体、垂体前叶较A组差异不显著，在卵泡、黄体中阳性产物表达均较A组显著降低，在子宫中表达较A组变化不明显；同B组相比：E组TNF-α免疫阳性产物在下丘脑外侧核、腹内侧核、弓状核、垂体前叶、子宫均显著增高，在视前内侧核、视交叉上核、视上核、视前大细胞核、室周核、室旁核、神经垂体、卵泡、黄体中阳性物质表达均显著降低；同C组相比：E组下丘脑视前内侧核、腹内侧核、背内侧核、弓状核、垂体前叶与中间部、子宫均显著增高，在室周核、黄体中均显著降低；同D组相比：E组下丘脑外侧核、背内侧核、腹内侧核、垂体各部、卵泡、卵巢基质均显著增高，在视上核、弓状核显著降低，在其它部位表达变化差异不显著。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。