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OBJECTIVE: Three sesquiterpene lactones 1-O-acetylbritannilactone, isoalantolactone and britannilactone were isolated from the roots of Inula helenium and the flowers of Inula japonica. The antitumor activities of the three sesquiterpenoids in the cell lines of HeLa, HEC-1, SHIN3, HOC-21 and HAC-2 were measured, and the relationship between structure and activity and the possible mechanisms were explored.

目的: 观察菊科植物中分离出的3种倍半萜化合物异土木香内酯、1-氧-乙酰大花旋覆花内酯和大花旋覆花内酯对体外培养的人子宫颈癌HeLa细胞、人子宫内膜癌HEC-1细胞、人卵巢透明细胞癌SHIN3及HOC-21细胞和人卵巢囊腺癌HAC-2细胞增殖的影响,研究这3种倍半萜化合物的体外抑制肿瘤细胞增殖作用及其结构与活性之间的构效关系,进而探讨3种倍半萜化合物的体外抑制肿瘤细胞增殖的可能机制。

On the basis of our series and the findings of Yapar et al, the sonographic features of pelvic TB may be categorized as wet type or dry type as follows. The wet type, found in 12 (75%) of 16 patients, is characterized by incompletely septated ascites, particulate ascites, loculated fluid (although clear ascites can also be commonly associated with tuberculous peritonitis ), a thickened peritoneum or omentum, and an adnexal mass, mimicking ovarian cancer; the dry type, found in a small number of cases, is characterized primarily by adnexal masses, adhesions, and loculated fluid, mimicking tubo-ovarian abscesses or complexes.

根据咱们和Yapar等人的发明,骨盆内部空腔TB的超声特征可以分为湿型或干型。16例病人中发明12例湿型TB,其特点是水臌内存在不完全的分隔、光点和多房性积液(尽管清亮的水臌通常也能归并结石性腹膜炎),和腹膜或网膜增厚和容易误诊成卵巢癌的附件团块;少量的病例呈干型TB,其特点主要是附件团块、粘连和多房性积液,象是输卵管-卵巢脓肿或复合体。

On the basis of our series and the findings of Yapar et al, the sonographic features of pelvic TB may be categorized as wet type or dry type as follows. The wet type, found in 12 (75%) of 16 patients, is characterized by incompletely septated ascites, particulate ascites, loculated fluid (although clear ascites can also be commonly associated with tuberculous peritonitis ), a thickened peritoneum or omentum, and an adnexal mass, mimicking ovarian cancer; the dry type, found in a small number of cases, is characterized primarily by adnexal masses, adhesions, and loculated fluid, mimicking tubo-ovarian abscesses or complexes.

根据我们和Yapar等人的发现,盆腔TB的超声特征可以分为湿型或干型。16例病人中发现12例湿型TB,其特点是腹水内存在不完全的分隔、光点和多房性积液(尽管清亮的腹水通常也能合并结核性腹膜炎),以及腹膜或网膜增厚和容易误诊成卵巢癌的附件团块;少量的病例呈干型TB,其特点主要是附件团块、粘连和多房性积液,象是输卵管-卵巢脓肿或复合体。

On the basis of our series and the findings of Yapar et al, the sonographic features of pelic TB may be categorized as wet type or dry type as follows. The wet type, found in 12 (75%) of 16 patients, is characterized by incompletely septated ascites, particulate ascites, loculated fluid (although clear ascites can also be commonly associated with tuberculous peritonitis ), a thickened peritoneum or omentum, and an adnexal mass, mimicking oarian cancer; the dry type, found in a small number of cases, is characterized primarily by adnexal masses, adhesions, and loculated fluid, mimicking tubo-oarian abscesses or complexes.

根据我们和Yapar等人的发现,盆腔TB的超声特征可以分为湿型或干型。16例病人中发现12例湿型TB,其特点是腹水内存在不完全的分隔、光点和多房性积液(尽管清亮的腹水通常也能合并结核性腹膜炎),以及腹膜或网膜增厚和容易误诊成卵巢癌的附件团块;少量的病例呈干型TB,其特点主要是附件团块、粘连和多房性积液,象是输卵管-卵巢脓肿或复合体。

In most cases, the diagnoses were based on the histopathologic examination of tissue obtained via laparotomy (7 patients, including 3 for failed medical treatment of pelvic inflammatory disease, 3 with assumed mucinous ovarian tumors, and 1 with an ovarian tumor) or peritoneoscopy (6 patients); cytologic examinations diagnosed TB for the others (3 patients).

大多数病例的诊断是基于剖腹手术(7例,包括3例按盆腔感染治疗失败的病人,3例怀疑粘连性卵巢肿瘤病人和1例怀疑卵巢肿瘤的病人)或腹腔镜(6例)所获取组织的病理学检查,另外3例的诊断是根据细胞学检查诊断TB的。10例病人中,4例先前有肺TB,3例子宫内膜TB。

In most cases, the diagnoses were based on the histopathologic examination of tissue obtained via laparotomy (7 patients, including 3 for failed medical treatment of pelvic inflammatory disease, 3 with assumed mucinous ovarian tumors, and 1 with an ovarian tumor) or peritoneoscopy (6 patients); cytologic examinations diagnosed TB for the others (3 patients).

大部分数病例的诊断是基于剖腹手术(7例,包括3例按骨盆内部空腔感染治疗掉败的病人,3例怀疑粘连性卵巢肿瘤病人和1例怀疑卵巢肿瘤的病人)或腹腔镜(6例)所获取组织的病理学检查,另外3例的诊断是根据细胞学检查诊断TB的。10例病人中,4例先前有肺TB,3例子宫内膜TB。

In most cases, the diagnoses were based on the histopathologic examination of tissue obtained ia laparotomy (7 patients, including 3 for failed medical treatment of pelic inflammatory disease, 3 with assumed mucinous oarian tumors, and 1 with an oarian tumor) or peritoneoscopy (6 patients); cytologic examinations diagnosed TB for the others (3 patients).

大多数病例的诊断是基于剖腹手术(7例,包括3例按盆腔感染治疗失败的病人,3例怀疑粘连性卵巢肿瘤病人和1例怀疑卵巢肿瘤的病人)或腹腔镜(6例)所获取组织的病理学检查,另外3例的诊断是根据细胞学检查诊断TB的。10例病人中,4例先前有肺TB,3例子宫内膜TB。

ABSTRACT Objective To discuss the clinical pathologic features and differential diagnosis of mixed germ cell sex cord stromal tumorwith malignant variant of germ cell tumor Methods The clinical pathologic datum and immunophenotype were studied in the case of ovary MGCSCST with malignant variance of germ cell tumor Results The patient's genital anatomy and female phenotype were normal,karotypes was 46xx with uterogestation The tumor tissue consisted of mixed germ cells and sex cord stromal cells with evident malignancy of mixed germ cells There was no atypical structure of gonadoblastoma in tumor tissue Conclusion MGCSCSST has complex morphosis,thus,to prevent misdiagnosis,more samples should be collected and more slices be cut The patient may have prognosis malo when there are high malignant variants of mixed germ cells in tumor tissue

目的 探讨混合性生殖细胞性索间质肿瘤(mixed germ cell sex cord stromal tumor,MGCSCST)伴恶性生殖细胞肿瘤变异型的临床病理特点及鉴别诊断。方法卵巢MGCSCST伴恶性生殖细胞肿瘤变异型的病例进行临床病理特征和免疫表型分析。结果患者生殖器的解剖结构和女性表型正常,染色体组型是46xx,足月妊娠。肿瘤组织由混合性生殖细胞和性索间质肿瘤构成,混合性生殖细胞有显著的恶性特征。瘤组织中没有典型的性腺母细胞瘤结构。结论 MGCSCST有复杂的形态结构,因此更多的取材和切片可以防止误诊,当肿瘤组织中的混合性生殖细胞有高度恶性变异时,患者预后不良。卵巢肿瘤;生殖细胞性索间质肿瘤;免疫组织化学

Patients were divided into 2 groups — women who had undergone bilateral prophylactic oophorectomy and thosewho had not. The researchers evaluated the risk reduction associated with prophylactic salpingo-oophorectomy by a time-dependent survival analysis adjustingfor covariates.

病患被分做两组—接受过两侧预防性的卵巢切除术的妇女和没有接受过的;研究者藉由共病校正之时间决定性存活分析,评估预防性的输卵管卵巢成形术的风险降低。

She was initially treated with unilateral salpingo-oophorectomy and a contralateral wedge resection for tumor invasion, followed by 6-course of the PVB (cisplatin+ vinblastine+ bleomycin) regimen, second operation, and an additional 6-course EP with complete remission.

她在十三岁时接受单侧卵巢输卵管切除术及对侧卵巢扇形切除术,接著接受六次的多种药物结合的化学治疗。然后在第二次手术后,发现残余肿瘤仍然存在,又接受保留生育能力的保守手术后,再追加额外六次的不同配方的化学治疗至疾病完全消除为止。

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