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Cancer of ovarian and transparent cell is most constant tumour of as epithelial as the ovarian surface of confuse of interblend of tumour of cell of the former reproduction that send a gender sex, especially with yolk bursa tumour and asexuality cell tumour are differentiated harder.

梗概: 卵巢透明细胞癌是最常和原发性生殖细胞肿瘤相混淆的卵巢表面上皮性肿瘤,尤其和卵黄囊瘤和无性细胞瘤较难鉴别。

Methods A total RNA from ten cases of ovarian cancer and contral normal ovarian tissues were extracted by a single step method. The cDNA retro-transcribed from equal quantity mRNA derived from ten cases of ovarian carcinoma and normal ovarian tissues, which were labeled cDNA strand with Cy5 and Cy3 fluorescence as probes.

按一步法分别抽提10例人卵巢癌组织和对照正常卵巢组织的总RNA并纯化mRNA;分别从10例取等量的人卵巢癌组织和对照组织的mRNA分别混合后逆转录合成以Cy5和Cy3标记的cDNA一链做探针,混合后在含有8464点人类体细胞基因模板的表达谱cDNA芯片上进行杂交。

Results 4 cases of gynecologic acute abdomen were dermoid cyst rupture, ovarian corpus luteum rupture, dermoid cyst torsion and ovarian abscess, and they have the corresponding CT, MRI findings.

结果 4例妇科急腹症分别为皮样囊肿破裂、卵巢黄体破裂、皮样囊肿蒂扭转及卵巢脓肿,它们均有相应的CT、MRI表现。

"Prophylactic oophorectomy should not be recommended to women with a high risk of breast cancer who do not have documented mutations in BRCA1 or BRCA2, since these cases may be linked to mutations in unidentified genes that do not increase the risk of ovarian cancer," he writes."The effectiveness of prophylactic oophorectomy in carriers of BRCA mutations provides a strong rationale for genetic testing in women with a strong family history of cancer."

不应该对乳腺癌发生危险较高,但没有明确的BRCA1或者BRCA2突变的女性,推荐进行预防性卵巢切除术,因为这些情况也许与未知的,与卵巢癌的发生无关的基因突变有关,」他写道:「对於BRCA突变体携带者进行预防性卵巢切除术,为有很强的肿瘤家族史的女性,进行遗传学检查,提供了强有力的依据。

Overexpression of PAKI protein may be involved in the tumorigenesis of epithelial ovarian neoplasms and it is associated closely with the malignant histological phenotype of ovarian carcinomas.

结论PAK1蛋白过度表达可能在卵巢上皮性肿瘤的发生发展中起重要作用,而且与卵巢癌的恶性组织学表型密切相关;在卵巢肿瘤PAK1蛋白的表达调控中,基因扩增以外的其他调节机制可能起更为关键的作用。

The females incubated at 33 , their ovarium has powerful cortex, the germinal epithlium produce oocyte, its medulla degenerate into ovarian cavity. During sexual differentiation, mitochondria and smooth endoplasmic reticulum in cells of ovary increase in quantity, they disintegrate after sexual differentiation. There are a lot of big grana in cells of ovary before sexual differentiation, in the course of sexual differentiation the quantity of the big grana decrease, while small grana increase and peakafter sexual differentiation. The males incubation at 26 , cortices of their testes degenerate into a thin albuginea. Medulla are formed by testicular cords in which scatter spermatogonium.

33℃下孵化的小龟卵巢皮质发达,由原始生殖细胞产生卵原细胞,髓质退化成为卵巢腔,分化时卵巢细胞的超微结构显示线粒体和内质网的数量大大增加,它们在分化结束后解体,分化前细胞内有较多的大颗粒,在分化中大颗粒减少,小颗粒增多,在分化后小颗粒达到最多。26℃下孵化的小龟精巢皮质退化成为一层薄的白膜,髓质有许多睾丸管构成,管腔内有散落排列的精原细胞。

It is useful to understand the relationship between the structures and functions of the ABC transporters and drug resistance and the prognosis of ovarian cancer patients for individualizing treatment in patients.

了解ABC转运体的结构、功能以及与卵巢癌耐药和患者预后的关系,为卵巢癌患者的个体化治疗提供理论依据,这也成为目前研究卵巢癌耐药机制的热点。

Stage I of both male and female stone flounder appears only once in all its life, and the germ cells are comprised by spermatogonia or oogonia. The gonad from Mar to Aug keeps at stage II. The gonad index of testis at this stage is 0.037%, and the amount of spermatogonia is increased quickly. There is some linear germ plasm in the cytoplasm of spermatogina. In ovary at this stage it is mostly composed by oocyte of phase 2 which the character is the appearance of yolk nucleus, and no zona radiate in membrane. The mean GI of ovary is 1.95%. From Sep to Oct gonad is at stage III which testis is composed by lots of spermatogina and few spermatocytes, and the mean GI of testis at this stage is 0.086%. In ovary the ooctyes at phase 3 are in dominate position, the yolk nucleus disappear. And the GI of this stage is 3.35%. Both testis and ovary are at stage IV in Nov. hi testis the germ cells are in spermiogenesis, and the mean GI is 0.93%. hi ovary the oocytes are mostly at phase 4, which are filled in the cytoplasm with vitellin granule, and the zona radiate in membrane begins to formation. Nucleus moves to one side of the oocyte gradually. The mean GI of ovary at this stage is 9.37%.

在每年的3月-8月期间性腺处于Ⅱ期,此期精巢中精原细胞明显增多,胞质局部可见有线状的生殖质存在,平均成熟系数为0.037%;卵巢中以2时相卵母细胞为主,可见细胞质中出现强嗜碱性的卵黄核,细胞外由一层滤泡细胞包围,但尚无放射带,平均成熟系数为1.95%。9月-10月期间性腺处于Ⅲ期,此期精巢中仍有大量精原细胞,同时可见部分精母细胞,平均成熟系数为0.086%;卵巢中以3时石鲜孟加限加$玩印面n洲匆s性腺发生、分化及发育的周年变化相卵母细胞为主,细胞质中的卵黄核己消失,平均成熟系数为3.35%。11月性腺处于IV期,此期精巢内精细胞正处于不同的形成过程中,平均成熟系数为0.93%;卵巢中以4时相卵母细胞为主,胞质中充满染成桔红色的卵黄颗粒。

With the aim of elucidating features which may help with differential diagnosis, this study reports the incidence and pathologic features of benign ovarian alterations, benign ovarian tumors, and occult primary and metastatic malignancies in prophylactic oophorectomies from 108 women with a BRCA mutation and from 35 women with other strong risk factors for hereditary breast/ovarian carcinoma.

为了阐明鉴别诊断的要点,本研究报道了卵巢良性病变、良性肿瘤和隐匿性原发性及转移性恶性病变的发生率和病理特征,所选病例都做了预防性卵巢切除术,包括108例伴有BRCA基因突变的女性和35例伴有其他遗传性乳腺/卵巢癌高危因素的女性。

Methods cDNA retro-transcribed from equal quantities of mRNA derived from high and low metastatic tumor cells or normal ovarian tissues were labeled with Cy5 and Cy3 fluorescein as probes. The mixed probe was hybridized with two pieces of BioDoor 4096 double dot human whole gene chip and scanned with a ScanArray 3000 laser scanner. The acquired image was analyzed by ImaGene 3.0 software.

按一步法分别抽提高低转移人卵巢癌细胞和对照正常卵巢组织的总RNA并纯化mRNA ;分别将等量的高低转移人卵巢癌细胞及对照组织的mRNA逆转录合成以Cy5和Cy3标记的cDNA一链做探针,分别混合后在 2张含有 4 0 96条双点人类全长基因的芯片上进行杂交。

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