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Objective To discuss the impact of zedoary turmerie oil injection over oncosis index and Bcl-2 expression of human ovarian cancer SKOV3 cell.

目的 观察莪术油注射液对人卵巢癌SKOV3细胞胀亡指数及Bcl-2表达的影响,探讨莪术油注射液致人卵巢癌SKOV3细胞胀亡的机制。

The preparation of monoclonal antibody of anti epithelial carcinoma of ovary by the cytomix method of oophoroma correlated antigen (CA 925 )was studied The antibody used was of IgG1 type.

采用自制卵巢癌相关抗原CA925经细胞融合方法,制备抗卵巢上皮癌单克隆抗体OC4D9,该抗体呈IgG1型,抗体效价ELISA104,抗体特异性较好。

Methods 42 patients with three-stage of ovarial epithelium carcinoma who underwent ovarian cancer reduction operation were randomly divided into two groups.20 patients in the control group accepeted Cisplatin-based combination chemotherapy for six months.22 patien...

方法将42例接受卵巢癌肿瘤减灭术治疗的Ⅲ期卵巢上皮性癌患者随机分为治疗组22例和对照组20例。

Abnormal expression of PTEN gene was involved in progression of ovarian cancer probably by decreasing cell adhesion and apoptosis, increasing cell mobility and angiogenesis. Reduced expression of PTEN gene was closely associated with tumorigenesis and pathobiological behavior of ovarian endometrioid cancer.

PTEN蛋白表达下调与卵巢恶性肿瘤的组织分化程度、临床病理分期和转移能力相关,与卵巢癌中的子宫内膜样癌PTEN蛋白表达关系更为密切。

FN have barrier action to tumor cell. Lower or absence of EN expression may play a role to judge prognosis in epithelial carcinoma ovary. Positive of EN expression symptomatize good prognosis in epithelial carcinoma of ovary.

FN对肿瘤细胞有屏障作用,FN表达降低或缺失可作为判定上皮性卵巢癌预后的指标之一,上皮性卵巢癌FN阳性表达是预后较好的指标之一。

FN have barrier action to tumor cell.Lower or absence of FN expression may play a role to judge prognosis in epithelial carcinoma ovary.Positive of FN expression symptomatize good prognosis in epithelial carcinoma of ovary.

FN对肿瘤细胞有屏障作用,FN表达降低或缺失可作为判定上皮性卵巢癌预后的指标之一,上皮性卵巢癌FN阳性表达是预后较好的指标之一。

The medical science research proves that the ovary cancer is unapparent in early symptom and when we discover the ovary cancer in final stage, it will make low survival rate.

医学研究证实卵巢癌在早期症状不明显,往往在最后阶段才发现,造成卵巢癌存活率很低。

D. The function of stimulating xenogenous lymphocyte proliferation was the same between peripheral DCs and ascites PCs. E. The percentage of CD3〓CD56〓 cells was the same in CIK cells co-culture with DCs transfected with SKOV3 RNA, CIK cells co-culture with DCs, and CIK cells. F. The expansion rate of CIK cells can be accelerated by co-culturing with loaded or unloaded DCs. However, the expansion rate between loaded or unloaded group is the same. F. The strongest cytotoxicity against SKOV3 cell line was achieved by CIK cells co-cultured with DCs loaded with SKOV3 lysate.

结果:1、腹水可获得0.83±0.24×10〓个AMC/ml,单核细胞有0.74±0.25×10〓个/ml;2、卵巢癌患者外周血可获得0.87±0.20×10〓个AMC/ml,单核细胞有0.92±0.17×10〓个/ml;3、除CD86外周血单核细胞来源DC表达较高以外,其他表面分子在不同来源DC间没有统计学差异;4、不同来源DC的异基因刺激能力没有差异;5、与负载或未负载卵巢癌抗原的DC共培养并不能提高CIK细胞群中CD3〓CD56〓细胞的数量;6、CIK细胞增殖显著,培养14天时可扩增19.18±4.70倍,培养21天时可扩增35.82±4.36倍;7、与未负载或负载DC共培养的CIK细胞在培养第14天后增殖速率大于单纯CIK细胞。

These results suggest that the expression of B7-H4 on tumor tissue may contribute to negative regulatory immunue responses against TILs in ovarian cancer.

B7-H4抑制了卵巢癌组织中肿瘤浸润淋巴细胞的功能,其有可能成为辅助卵巢癌诊治的新的靶目标。

These results suggest that the expression of b7-h4 on tumor tissue may contribute to negative regulatory immunue responses against tils in ovarian cancer.it may be a new target of diagnosis and/or treatment for ovarian cancer.

b7-h4抑制了卵巢癌组织中肿瘤浸润淋巴细胞的功能,其有可能成为辅助卵巢癌诊治的新的靶目标。

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