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The regulation of gene expression is to have relations to the assembly of the DNA binding proteins which bind to DNA to initiate the transcription. Some of these proteins have the ability to promote bending or looping of DNA. The FIS protein regulates gene expression in Escherichia coli by this property of bending DNA. There are many researches to discover the mechanism of FIS protein binds to DNA. However the experiment data only show the supposititious results and figure out the model of FIS-DNA complex structure. This research uses molecular dynamics simulation to compute the detail of the interaction between FIS and DNA. We observed FIS prominently affects the DNA bending by the type of local bending. Analyzing the DNA structure properties, roll and slide, also demonstrates the local bending type and region. The hydrogen bonds between FIS and DNA are analyzed to compare with the experiment data. Finally we compute the binding free energy between FIS and DNA to estimate the result of simulation and compare with the value of λ-repressor-DNA complex.

基因的表现与结合於DNA促使DNA转录作用起始的DNA结合蛋白组装有关,一些这类的蛋白质具有促使DNA扭曲或将DNA形成环状的能力,FIS蛋白质即是藉由扭曲DNA的特性调控大肠杆菌基因的表现,目前已有很多的研究发现FIS与DNA结合的机转,然而这些实验的数据仅能显示推测性的结果,进而利用这些结果推论出FIS与DNA聚合体结构的模型,本研究利用分子动态模拟的方式计算FIS与DNA交互作用的细节,我们观察到FIS主要影响DNA的扭曲方式为DNA区域扭曲的类型,并且分析DNA结构特性roll与slide也指出扭曲方式为区域扭曲与其扭曲的区域,我们也分析FIS与DNA之间的氢键,并且与实验的资料作比较,最后我们计算FIS与DNA之间的结合自由能评估模拟的结果,并且计算出的值和λ-repressor与DNA聚合体结构的实验值作比较。

What is supremely true of living objects is no less true of ideas, which are also alive.

所谓要活的丰富充实也即是要扩大和加强我们的各种联系。

This is known as .pulse swallowing..

即是。跳动忍受。。

Trip no furtherpretty sweeting; Journeys end in loves meeting. Every wise man's son doth know. What is love?

可爱的甜心,不要再往前走;恋人们相会即是旅程的尽头,每个聪明人的儿子都明了。

This paper is in the background, the authors couplet synesthesia definition physiological basis, and its artistic and aesthetic issues related to the associated exposition, simply introduced as a result of the distinction between the vocal and instrumental music together synesthesia effects.

本文即是在这样的背景下产生的,笔者在对联觉定义、生理基础、以及它和审美艺术之间的联系等相关问题论述后,简单介绍了由于声乐与器乐之间的区别导致的联觉效应的差异。

Then I started writing, my first few novels, that is, at this writing in the teahouse.

我这时才开始写作,我的最初几篇小说,即是在这家茶馆里写的。

Utilizing the positive temperature coefficient effect, the resistance of polymer will rise as temperature increasing sharply.

利用其PTC效应,电阻能随温度急剧上升,亦即是当导电复合材料之温度上升至一关键温度时,其电阻会明显地大幅上升,达到暂时绝缘或短路的效果。

The Ten-Point Programme for Resisting Japan and Saving the Nation now proposed by our Party spells out concretely the way to win final victory in the War of Resistance.

本党今天所提出的抗日救国的十大纲领,即是争取抗战最后胜利的具体的道路。

In relation to the current specific political task this question means: Is the Kuomintang to be raised to the level of the Ten-Point Programme for Resisting Japan and Saving the Nation, to the level of the total resistance advocated by the Communist Party?

在当前的具体的政治任务中,这个问题即是说:把国民党提高到共产党所主张的抗日救国十大纲领和全面抗战呢,还是把共产党降低到国民党的地主资产阶级专政和片面抗战?

For example, lipids are softeners and lubricants that the baker blends into a cake formula to tenderize cake.

如油脂即是软化剂,又是润滑剂,焙烤工人把油脂掺入糕点配料中使其嫩化。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。