危险

The research still shows that the risk of dying from stroke, aneurism,high blood pressure and other cardiovascular diseases are also increased.

帖主对此回复很满意，所以奖励 1 积分给08missing08[14]研究还表明，死于中风、动脉瘤、高血压和其他心血管疾病的危险也有所增加。

Studies also have shown that the risks of stroke,aneurism,high blood pressure and other cardiovascular diseases have increased from what people died

帖主对此回复很满意，所以奖励 1 积分给風箏斷線[14]研究还表明，死于中风、动脉瘤、高血压和其他心血管疾病的危险也有所增加。

High blood pressure, high blood ester, smoking, drinking, sugar diabetes, carotid sclerosis, fatness, atria quiver, blood vessel inflammation, blood vessel monstrosity, encephalic aneurism and high homocysteine are absolute danger factors, orderliness of living, morever incidence are masculine.

青年型脑血管病发生率的逐渐增高，其发病是一个极复杂的过程，其中高血压、高血脂、吸烟、酗酒、糖尿病、颈动脉硬化斑块、肥胖、房颤、血管炎、脑血管畸形、颅内动脉瘤、同型半胱氨酸增高，都是独立的危险因素，因此应积极早期预防，降低及避免青年型脑血管病的发生。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

On the other hand, aniline are dangerous chemicals, the device management and high maintenance requirements.

另一方面，苯胺属于危险化学品，其装置的管理与维护要求颇高。

We should take measures to save the endangered anima ls and pla nts.

我们应该采取措施挽救这些面临危险的动植物。

Which do you think is the most dangerous animal in the world?

你认为哪种动物是世界上最危险的动物？

Communism's collapse has called forth old animosities and new dangers.

共产主义的崩溃激起了旧的仇恨和新的危险。

Communism's collapse has called forth old animosities , and new dangers.

苏联共产党的倒台使旧的民族仇恨重新点燃，也产生一些新的危险

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。