卤素盐

Melamine Cyanurate is a white crystal power with is a excellent non-halogen N flame product is mainly used as non-halogen flame retardant for synthetic resin,synthetic rubber and plastic products;solid lubricant in lubricating oil and grease;fire retardant in fire-proofing coating;lubricant in lubricating oil and grease;fire retardant in fire-proofing coating;lubricant in the cosmetic.

三聚氰胺氰尿酸盐是一种白色结晶权力xxxxx是一个优秀的非卤素n火焰xxxxx产品，主要是用来作为非卤素阻燃剂的合成树脂（坝，聚氯乙烯，聚苯乙烯，聚甲醛），合成橡胶和塑料制品；固体润滑剂润滑油和润滑脂；阻燃剂在防火涂料；润滑剂在润滑油和润滑脂；阻燃剂在防火涂料；润滑剂在化妆品。

Becausethe ginger flavine and its the synonym have many kinds of pharmacologyactiveness, at present, conducted the research take this kind ofcompound as the forerunner which the structure optimized to cause inthe world scope chemist and the medicine scientist's widespreadattention, take the ginger flavine as the raw material, first had thefunction production corresponding sodium salt in the organic solventby NaOH or NaOEt and a-H, then and 卤代烃carried on the substitution reaction, the response condition which theresearch optimized, and grew this derivative monocrystal with thesolution law.

由于姜黄素及其类似物所具有的多种药理活性，目前，以该类化合物为先导进行结构优化的研究引起了世界范围内的化学家和药物学家的广泛关注，以姜黄素为原料，先在有机溶剂中以NaOH或NaOEt与a-H发生作用生成相应钠盐，再和卤代烃进行取代反应，研究优化的反应条件，并用溶液法生长该衍生物单晶体。

The absence of hydrogen iodide salt formation was demonstrated by a negative halogen analysis.

卤素分析负反应表明没有氢碘酸盐的生成。

This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本发明提供式的化合物；其中：R 1 为选自基团和的部分；n为整数1或2；R 2 选自氢、氨基、-NR 6 R 7 、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、具有2到12个碳原子的视情况经取代的炔基、卤素和具有1到4个独立地选自N、O和S的杂原子的视情况经取代的5元到10元杂芳基环；R 3 选自氢、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、乙烯基、具有2到12个碳原子的视情况经取代的炔基和卤素；R 4 为H、具有1到12个碳原子的视情况经取代的烷基、具有3到8个碳原子的环烷基、具有5到10个碳原子的双环烷基或视情况经取代的芳烷基；R 5 为OH或-OH 8 ；R 6 和R 7 各自独立地为H或具有1到12个碳原子的烷基，或当视情况与其所连接的氮原子连接在一起时形成3元到8元饱和杂环基环；R 8 为具有1到12个碳原子的视情况经取代的烷基；或其互变异构体或医药学上可接受的盐。

The present invention relates to sulphonyloxazolamines of general formula, wherein R, R represent independently from each other H, A,-(CH2)n-Ar or alkenyl with 2-6 C atoms, R and R together also represent a mononuclear saturated heterocycle with 1-2 N, O and/or S atoms, Z is H, A, CF3, NO2, Hal, OH, OA, NH2, NHA or NA2, A represents alkyl with 1-6 C atoms, Ar is Z-monosubstituted or Z-disubstituted phenyl, halogen is F, Cl, Br or I, n is 1 or 2 or the physiologically acceptable salts or solvates thereof.

本发明涉及式磺酰基∴唑胺或其生理上可接受的盐或溶剂化物，其中R 1 ，R 2 每一个相互独立为H、A、－(CH 2 )n－Ar或具有2到6个C原子的链烯基，R 1 和R 2 也一起为具有1到2个N、O和/或S原子的单核饱和杂环，Z为H、A、CF 3 、NO 2 、卤素、OH、OA、NH 2 。NHA或NA 2 ，A为具有1到6个C原子的烷基，Ar为被Z取代的或Z二－取代的苯基，卤素为F、Cl、Br或I，n为1或2。

The present invention relates to compounds of formula wherein R is hydrogen, lower alkyl, lower alkoxy, halogen or lower alkyl substituted by halogen; R is hydrogen or halogen; or R and R are together with the carbon atom to which they are attached -CH=CH-CH=CH-; R is hydrogen, lower alkyl, phenyl optionally substituted by halogen, or is hetaryl, optionally substituted by lower alkyl; R is hydrogen, lower alkyl, phenyl, benzyl, lower alkenyl, lower alkoxy, phenyloxy, benzyloxy, S-lower alkyl, halogen, CN, lower alkyl substituted by halogen or O-lower alkyl substituted by halogen; R is hydrogen or lower alkyl, aryl is phenyl or naphthyl; n is 1, 2 or 3; m is 1 or 2; and pharmaceutically acceptable acid addition salts and tautomeric forms thereof.

本发明涉及式化合物及其可药用的酸加成盐和互变异构形式，其中R 1 是氢、低级烷基、低级烷氧基、卤素或被卤素取代的低级烷基；R是氢或卤素；或R 1 和R与它们连接的碳原子一起是-CH＝CH-CH＝CH-；R 2 是氢、低级烷基、任选被卤素取代的苯基或者是任选被低级烷基取代的杂芳基；R 3 是氢、低级烷基、苯基、苄基、低级链烯基、低级烷氧基、苯氧基、苄氧基、S-低级烷基、卤素、CN、被卤素取代的低级烷基或被卤素取代的O-低级烷基；R 4 是氢或低级烷基，芳基是苯基或萘基；n是1、2或3；m是1或2。

Under normal temp., PVF2 has a fine corrosion resistance to many organic solvents like halogen, halogenated hydrocarbon, strong oxidant, boiling acid and alkali; UHMWPE has a fine corrosion resistance to inoxidable acid (dilute sulfuric acid, nitric acid and large concen-tration hydrochloric acid, phosphorus acid, hydrofluoric acid, formic acid and acetic acid), ammonia, amine and various alkali and salty solutions. Both materials can't resist the corrosion of strong oxidable acid.

在常温下，PVF2对卤素、卤代烃、强氧化剂、沸酸、碱等多种有机溶剂都有良好耐蚀性；UHMWPE对非氧化性酸(稀硫酸、硝酸及浓度较大的盐酸、磷酸、氢氟酸、甲酸、乙酸)、氨和胺及各种碱、盐溶液都有良好的耐蚀性，两种材料都不耐强氧化性酸的腐蚀。

Under normal temp., PVF2 has a fine corrosion resistance to many organic solvents like halogen, halogenated hydrocarbon, strong oxidant, boiling acid and alkali UHMWPE has a fine corrosion resistance to inoxidable acid (dilute sulfuric acid, nitric acid and large concen-tration hydrochloric acid, phosphorus acid, hydrofluoric acid, formic acid and acetic acid), ammonia, amine and various alkali and salty solutions. Both materials cant resist the corrosion of strong oxidable acid.

在常温下，PVF2对卤素、卤代烃、强氧化剂、沸酸、碱等多种有机溶剂都有良好耐蚀性；UHMWPE对非氧化性酸(稀硫酸、硝酸及浓度较大的盐酸、磷酸、氢氟酸、甲酸、乙酸)、氨和胺及各种碱、盐溶液都有良好的耐蚀性，两种材料都不耐强氧化性酸的腐蚀。

Under normal temp., PVF2 has a fine corrosion resistance to many organic solvents like halogen, halogenated hydrocarbon, strong oxidant, boiling acidalkali; UHMWPE has a fine corrosion resistance to inoxidable acid (dilute sulfuric acid, nitric acidlarge concen-tration hydrochloric acid, phosphorus acid, hydrofluoric acid, formic acidacetic acid), ammonia, aminevarious alkalisalty solutions. Both materials can't resist the corrosion of strong oxidable acid.

在常温下，PVF2对卤素、卤代烃、强氧化剂、沸酸、碱等多种有机溶剂都有良好耐蚀性；UHMWPE对非氧化性酸(稀硫酸、硝酸及浓度较大的盐酸、磷酸、氢氟酸、甲酸、乙酸)、氨和胺及各种碱、盐溶液都有良好的耐蚀性，两种材料都不耐强氧化性酸的腐蚀。

A compound of formula wherein R1 is hydrogen, halo or methoxy; R2 is hydrogen, halo, methyl, ethyl or methoxy; R3 is carboxy, tetrazolyl, or -CONHSO2R where R is methyl, ethyl, phenyl, 2,5-dimethylisoxazolyl or trifluoromethyl; T is -CH2- or -SO2-; and ring A is 3-chlorophenyl, 4-chlorophenyl, 3-trifluoromethylphenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3-fluoro-4-chlorophenyl, 3-chloro-4-fluorophenyl or 2,3-dichloropyrid-5-yl; or a pharmaceutically acceptable salt or prodrug thereof, as well as pharmaceutical compositions containing them are described and claimed.

本发明涉及一种式化合物，其中R 1 是氢原子、卤素或甲氧基；R 2 是氢原子、卤素、甲基、乙基或甲氧基；R 3 是羧基、四唑基或－CONHSO 2 R 4 ，其中R 4 是甲基、乙基、苯基、2，5－二甲基异∴唑基或三氟甲基；T是－CH 2 －或－SO 2 －；环A是3－氯苯基、4－氯苯基、3－三氟甲基苯基、3，4－二氯苯基、3，4－二氟苯基、3－氟－4－氯苯基、3－氯－4－氟苯基或2，3－二氯吡啶－5－基；或其药用允许的盐或前药，还包括所阐述和要求权利的含有它们的药用组合物。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。