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The profile of liver CYP450 induction by DEX in male rat After 4 daily i.p. administering of 0,25, 50 and lOOmg/kg/d DEX in male Wistar rat, it was determined the total CYP450 content, the mRNA and protein expression levels of CYP3A1, CYP3A2 and CYP2B1/2, and the ERD (CYP3A catalytic activity), PROD (CYP2B catalytic activity) and BROD (total CYP450 catalytic activity) in livers.

DEX对雄性大鼠肝脏CYP450的诱导效应雄性Wistar大鼠腹注0、25、50和100mg DEX/kg/d诱导处理4天后,测定大鼠肝脏总CYP450含量,CYP3A1、CYP3A2和CYP2B1/2的mRNA及蛋白表达水平,肝脏红酶素脱甲基酶(ERD,CYP3A活性),苄氧基试卤灵脱乙基酶(PROD,CYP2B活性),苯氧基试卤灵脱乙基酶(BROD,总CYP450活性),结果表明,CYP450含量、ERD、PROD和BROD在DEX多次诱导后都有升高,CYP3A1 mRNA表达水平、蛋白含量和酶活性有明显的升高,剂量效应关系明显;CYP3A2蛋白也有明显升高,而其mRNA表达水平却没有变化,提示CYP3A1和CYP3A2的诱导机制可能不同。

The profile of liver CYP450 induction by DEX in male ratAfter 4 daily i.p. administering of 0,25, 50 and lOOmg/kg/d DEX in male Wistar rat, it was determined the total CYP450 content, the mRNA and protein expression levels of CYP3A1, CYP3A2 and CYP2B1/2, and the ERD (CYP3A catalytic activity), PROD (CYP2B catalytic activity) and BROD (total CYP450 catalytic activity) in livers.

DEX对雄性大鼠肝脏CYP450的诱导效应雄性Wistar大鼠腹注0、25、50和100mg DEX/kg/d诱导处理4天后,测定大鼠肝脏总CYP450含量,CYP3A1、CYP3A2和CYP2B1/2的mRNA及蛋白表达水平,肝脏红酶素脱甲基酶(ERD,CYP3A活性),苄氧基试卤灵脱乙基酶(PROD,CYP2B活性),苯氧基试卤灵脱乙基酶(BROD,总CYP450活性),结果表明,CYP450含量、ERD、PROD和BROD在DEX多次诱导后都有升高,CYP3A1 mRNA表达水平、蛋白含量和酶活性有明显的升高,剂量效应关系明显;CYP3A2蛋白也有明显升高,而其mRNA表达水平却没有变化,提示CYP3A1和CYP3A2的诱导机制可能不同。

First we will use sea water for breeding, then we will develop and utilize the moderate brine and saturated brine drained after breeding to extract bromine for raw salt solarization.

项目拟在盐碱滩上引入海水,先用海水进行养殖,然后对养殖后排出的中度卤水、饱和卤水进行开发利用,提取溴素,晒制原盐,再将晒盐后排出的苦卤进行回收加工氯化镁、氢氧化镁等化工产品,最终实现海水"零排放",达到最大限度利用资源,降低生产成本,实现可持续发展。

The rules of photo bioactivities are: Without illumination, the tested xanthene derivatives showed almost the same level of inherent toxicity to the same organism, which showed the inherent toxicity of xanthene derivatives were primarily dependent on the structure of parent molecule. Upon illumination, the photosensitizers showed obvious phototoxicity to all organisms. The xanthene derivatives showed stronger phototoxicity to Gram-positive bacteria. With the increasing number of halogen substituents, the singlet oxygen yields increased and the phototoxic activity increased too.

呫吨类化合物的生物活性的变化规律为:未经光照的条件下,呫吨类化合物的对同种待测微生物的固有生物活性基本相同,说明固有毒性可能主要决定于化合物分子的母核结构,其卤素取代基团对其影响较小;经实验光源照射下,所测MLC值明显低于未经光照条件下的值,表明呫吨类化合物对三种微生物的光敏活性明显强于对其相应的固有活性;呫吨类化合物对革兰氏阳性菌能发挥较大的光敏活性。

ABSTRACT To study the antibacterial constituents from the fermentation broth of endophytic fungus Penicillium sp. 0935030 from mangrove plant Acrostichum aureurm. The separation procedure was guided by antibacterial bioassay. Seven compounds were isolated and purified by column chromatography, and their structures were identified as cyclo (1), cyclo (2), 1(2Furanyl)1,2ethanediol (3),(3β,4β,22β)olean12ene3,22,23triol (4), mannitol (5), uridine (6), and liquiritigenin (7) by physicochemical and spectral data.

为研究红树林植物卤蕨内生真菌Penicillium sp.0935030发酵物中的抗菌活性成分,采用活性追踪的方法,用多种色谱技术对化合物进行分离纯化,通过理化性质和光谱数据鉴定出7个化合物,分别为:环(1),环(2),1呋喃基1,2乙二醇(3),(3β,4β,22β)12烯3,22,23三羟基齐墩果烷(4),甘露醇(5),尿苷(6)和甘草素(7)。

Here hot halogen has the characteristic very much, the common hot halogen is boils with the jar, after but here is the halogen is good again uses the bittern to recook fries, recommends you to choose the beef element to bundle the chicken, the halogen intestines, the pig ear matches the fragrant-flowered garlic "four to gather one"!

这里的热卤很有特色,一般的热卤是用罐子煮的,而这里是卤好之后再用卤水回锅炒,推荐你选择牛肉素捆鸡、卤肠子,猪耳朵搭配韭菜的&四合一&!

These floodlights are designed for tungsten halogen lamps.

灯具中采用的光源素卤钨灯。

The application results from fluorination showed microwave heating could accelerate chemical reactions markedly. The reaction time could be shortened 50% at least than that of conventional heating. The relationship between fluorinating agents\' structure and their activity was studied systematically. In addition, an anhydrous KF with higher activity was prepared by using expansion effect of microwave heating. As we known, solvents were very important to reaction. The comprehensive study showed some less polar aromatic solvents could be used as dipolar solvents. In addition, they had better effect than dipolar solvents in some occasions, such as fluorination of chlorobenzaldehydes and chlorinated diphenyl ketones etc. The primary applications of ionic liquids were also studied which indicated reactions with ionic liquids as solvents were more efficient and simple.

研究表明,微波是一种节能高效的加热方式,在微波作用下的卤素交换氟化反应具有反应速度快、转化率高、选择性好的优点,其反应时间可较常规加热缩短50%以上;同时也系统地研究了氟化剂种类及制备方式对其反应活性的影响,并利用微波加热的膨化作用制备出了一种活性较高的KF,其活性与喷雾干燥KF相差不大;溶剂对反应具有重要的作用,在此系统地研究了强极性非质子溶剂和中等极性非质子溶剂的应用情况,发现一些中等极性的非质子溶剂如硝基芳烃和氯代芳烃类溶剂在氯代苯甲醛类化合物的氟化反应中具有比强极性非质子溶剂更好的使用效果。

The main reasons were that the algae and organism in the water decreased the ability of removing pollutants by coagulations, the algae which grown again in the open sedimentation tank weakened the removal effect of algae by coagulation; because of the accumulation of algae and algae toxin in the filtration tank, the concentration of algae toxin in the effluent increased; by the function of fluid chlorine, the algae and organisms after the filtration will release microalgae toxin and produce a lot of byproduct such as microalgae toxin, sobomyl and so on, meanwhile, the chlorination produce considerable halide and halo-acetic acid and other disinfection byproduct.

主要表现在藻类和溶解性有机物的存在降低了混凝去除污染物的能力;藻类在露天平流沉淀池中再生长,抵消了混凝除藻效果;藻类和藻毒素在滤池中积累,导致滤后藻毒素升高;穿透滤池的藻类和有机物在液氯作用下,释放微囊藻毒素、土臭素和二甲基异冰片等胞内物质,同时生成数量可观的卤代烃和卤乙酸等消毒副产物。

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On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面,更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值,分为几个相等的区间作为横轴,并将各区间内所测定值依所出现的次数累积而成的面积,用柱子排起来的图形,也叫做柱状图。

You rap, you know we are not so good at rapping, huh?

你唱吧,你也知道我们并不那么擅长说唱,对吧?