卤素

Besides these methods of introducing different halogen atom to aliphatic hydrocarbon and aromatic hydrocarbon were also reviewed.

根据目标分子结构的特点，可以分为两种情况：一是直接在脂肪醇中引入不同的卤素原子；二是在含有多官能团的芳香烃中引入卤素原子。

Melamine Cyanurate is a white crystal power with is a excellent non-halogen N flame product is mainly used as non-halogen flame retardant for synthetic resin,synthetic rubber and plastic products;solid lubricant in lubricating oil and grease;fire retardant in fire-proofing coating;lubricant in lubricating oil and grease;fire retardant in fire-proofing coating;lubricant in the cosmetic.

三聚氰胺氰尿酸盐是一种白色结晶权力xxxxx是一个优秀的非卤素n火焰xxxxx产品，主要是用来作为非卤素阻燃剂的合成树脂（坝，聚氯乙烯，聚苯乙烯，聚甲醛），合成橡胶和塑料制品；固体润滑剂润滑油和润滑脂；阻燃剂在防火涂料；润滑剂在润滑油和润滑脂；阻燃剂在防火涂料；润滑剂在化妆品。

Becausethe ginger flavine and its the synonym have many kinds of pharmacologyactiveness, at present, conducted the research take this kind ofcompound as the forerunner which the structure optimized to cause inthe world scope chemist and the medicine scientist's widespreadattention, take the ginger flavine as the raw material, first had thefunction production corresponding sodium salt in the organic solventby NaOH or NaOEt and a-H, then and 卤代烃carried on the substitution reaction, the response condition which theresearch optimized, and grew this derivative monocrystal with thesolution law.

由于姜黄素及其类似物所具有的多种药理活性，目前，以该类化合物为先导进行结构优化的研究引起了世界范围内的化学家和药物学家的广泛关注，以姜黄素为原料，先在有机溶剂中以NaOH或NaOEt与a-H发生作用生成相应钠盐，再和卤代烃进行取代反应，研究优化的反应条件，并用溶液法生长该衍生物单晶体。

This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本发明提供式的化合物；其中：R 1 为选自基团和的部分；n为整数1或2；R 2 选自氢、氨基、-NR 6 R 7 、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、具有2到12个碳原子的视情况经取代的炔基、卤素和具有1到4个独立地选自N、O和S的杂原子的视情况经取代的5元到10元杂芳基环；R 3 选自氢、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、乙烯基、具有2到12个碳原子的视情况经取代的炔基和卤素；R 4 为H、具有1到12个碳原子的视情况经取代的烷基、具有3到8个碳原子的环烷基、具有5到10个碳原子的双环烷基或视情况经取代的芳烷基；R 5 为OH或-OH 8 ；R 6 和R 7 各自独立地为H或具有1到12个碳原子的烷基，或当视情况与其所连接的氮原子连接在一起时形成3元到8元饱和杂环基环；R 8 为具有1到12个碳原子的视情况经取代的烷基；或其互变异构体或医药学上可接受的盐。

According to the H NMRstudy, it was found that the protons on the cyclopentadienyl ring of 〓 were not splitted, but when one proton on the cyclopentadienylring was substituted by methyl, that is in〓 complexes, thefour protons on the ring were splitted into four groups,the 〓 between the onesignal and the others is large, the total splitting is over 2ppm. The splittings werealso affected by the halides linked with the titanium, they increase according to theorder of CI, Br, I. By the study of the 〓 Sn NMR, it is found that the chemicalshifts of 〓 are present in low field. It is assume that the large space strain causesthe angles of the tin linked with ligands deviate from the normal tetrahedral anglesresults low field shift for 〓Sn. And by MS study,there were no molecular ions for 〓 complexes in the spectra. However, for 〓 when X=CI,Br,NCO and Ar is tolyl or phenyl group,there were molecular ions,but theirabundances were very small,and no that for the iodide was found.

钛上的卤素对茂环氢的裂分也有影响，依〓，Br，I顺序，卤素对茂环氢的裂分依次加大；通过对〓的研究发现，以上这些化合物〓的化学位移都出现在低场，认为大的空间张力造成的锡的键角偏离正常的锡的四面体键角是造成〓化学位移出现在低场的原因；对这些化合物质谱的研究发现，〓系列化合物得不到分子离子峰，而〓系列的化合物，当X=〓，NCO和苯环上不带取代基或只带甲基时，则出现分子离子峰，但丰度很低，而相应的碘化物和其它化合物则没出现分子离子峰。

Third, nearly seven times the service life of halogen lamps; As already mentioned, halogen light-emitting principle is caused by a tungsten filament heating, while the tungsten filament in the long term there will definitely be blown under high temperature damage, so they are the life of 200 ~ 300 hours or so.

第三，近7倍于卤素灯的使用寿命；前面已经讲到，卤素灯的发光原理是由钨丝发热所致，而钨丝在长久的高温下难保不烧断损坏，所以它们的使用寿命只有200~300个小时左右。

The present invention relates to sulphonyloxazolamines of general formula, wherein R, R represent independently from each other H, A,-(CH2)n-Ar or alkenyl with 2-6 C atoms, R and R together also represent a mononuclear saturated heterocycle with 1-2 N, O and/or S atoms, Z is H, A, CF3, NO2, Hal, OH, OA, NH2, NHA or NA2, A represents alkyl with 1-6 C atoms, Ar is Z-monosubstituted or Z-disubstituted phenyl, halogen is F, Cl, Br or I, n is 1 or 2 or the physiologically acceptable salts or solvates thereof.

本发明涉及式磺酰基∴唑胺或其生理上可接受的盐或溶剂化物，其中R 1 ，R 2 每一个相互独立为H、A、－(CH 2 )n－Ar或具有2到6个C原子的链烯基，R 1 和R 2 也一起为具有1到2个N、O和/或S原子的单核饱和杂环，Z为H、A、CF 3 、NO 2 、卤素、OH、OA、NH 2 。NHA或NA 2 ，A为具有1到6个C原子的烷基，Ar为被Z取代的或Z二－取代的苯基，卤素为F、Cl、Br或I，n为1或2。

If monomer passes atom to transfer freedom radical group above all reacts, attainable extreme contains haloid atomic polymer, and haloid and atomic itself can serve as the raw material that folds nitride, click reaction to come true to be transformed further to polymer structure to use thereby offerred a possibility, golas [10] did special overview for this.

假如单体首先经过原子转移自由基聚合反应后，则可得到末端含有卤素原子的聚合物，而卤素原子本身可以作为叠氮化物的原料，从而为采用点击反应对聚合物结构实现进一步改造提供了可能，Golas等[10]为此做了专门的综述。

A compound of formula wherein R1 is hydrogen, halo or methoxy; R2 is hydrogen, halo, methyl, ethyl or methoxy; R3 is carboxy, tetrazolyl, or -CONHSO2R where R is methyl, ethyl, phenyl, 2,5-dimethylisoxazolyl or trifluoromethyl; T is -CH2- or -SO2-; and ring A is 3-chlorophenyl, 4-chlorophenyl, 3-trifluoromethylphenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3-fluoro-4-chlorophenyl, 3-chloro-4-fluorophenyl or 2,3-dichloropyrid-5-yl; or a pharmaceutically acceptable salt or prodrug thereof, as well as pharmaceutical compositions containing them are described and claimed.

本发明涉及一种式化合物，其中R 1 是氢原子、卤素或甲氧基；R 2 是氢原子、卤素、甲基、乙基或甲氧基；R 3 是羧基、四唑基或－CONHSO 2 R 4 ，其中R 4 是甲基、乙基、苯基、2，5－二甲基异∴唑基或三氟甲基；T是－CH 2 －或－SO 2 －；环A是3－氯苯基、4－氯苯基、3－三氟甲基苯基、3，4－二氯苯基、3，4－二氟苯基、3－氟－4－氯苯基、3－氯－4－氟苯基或2，3－二氯吡啶－5－基；或其药用允许的盐或前药，还包括所阐述和要求权利的含有它们的药用组合物。

Annual output of halogen, carbon film, carbon fiber heating tube 600 10000, is currently China's largest manufacturers of halogen heating tubes.

年产卤素、碳片、碳纤维发热管600多万支，目前是中国大型的卤素发热管生产厂家。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。