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The profile of liver CYP450 induction by DEX in male rat After 4 daily i.p. administering of 0,25, 50 and lOOmg/kg/d DEX in male Wistar rat, it was determined the total CYP450 content, the mRNA and protein expression levels of CYP3A1, CYP3A2 and CYP2B1/2, and the ERD (CYP3A catalytic activity), PROD (CYP2B catalytic activity) and BROD (total CYP450 catalytic activity) in livers.

DEX对雄性大鼠肝脏CYP450的诱导效应雄性Wistar大鼠腹注0、25、50和100mg DEX/kg/d诱导处理4天后,测定大鼠肝脏总CYP450含量,CYP3A1、CYP3A2和CYP2B1/2的mRNA及蛋白表达水平,肝脏红酶素脱甲基酶(ERD,CYP3A活性),苄氧基试卤灵脱乙基酶(PROD,CYP2B活性),苯氧基试卤灵脱乙基酶(BROD,总CYP450活性),结果表明,CYP450含量、ERD、PROD和BROD在DEX多次诱导后都有升高,CYP3A1 mRNA表达水平、蛋白含量和酶活性有明显的升高,剂量效应关系明显;CYP3A2蛋白也有明显升高,而其mRNA表达水平却没有变化,提示CYP3A1和CYP3A2的诱导机制可能不同。

The profile of liver CYP450 induction by DEX in male ratAfter 4 daily i.p. administering of 0,25, 50 and lOOmg/kg/d DEX in male Wistar rat, it was determined the total CYP450 content, the mRNA and protein expression levels of CYP3A1, CYP3A2 and CYP2B1/2, and the ERD (CYP3A catalytic activity), PROD (CYP2B catalytic activity) and BROD (total CYP450 catalytic activity) in livers.

DEX对雄性大鼠肝脏CYP450的诱导效应雄性Wistar大鼠腹注0、25、50和100mg DEX/kg/d诱导处理4天后,测定大鼠肝脏总CYP450含量,CYP3A1、CYP3A2和CYP2B1/2的mRNA及蛋白表达水平,肝脏红酶素脱甲基酶(ERD,CYP3A活性),苄氧基试卤灵脱乙基酶(PROD,CYP2B活性),苯氧基试卤灵脱乙基酶(BROD,总CYP450活性),结果表明,CYP450含量、ERD、PROD和BROD在DEX多次诱导后都有升高,CYP3A1 mRNA表达水平、蛋白含量和酶活性有明显的升高,剂量效应关系明显;CYP3A2蛋白也有明显升高,而其mRNA表达水平却没有变化,提示CYP3A1和CYP3A2的诱导机制可能不同。

Erythrosin e system and ethyl eosin system can be applied to the determination of chlorpromazine hydrochloride with conventional spectrophotometry, and eosin Y system can be used by color fading spectrophotometry.

在NaAc HCl缓冲介质中,盐酸氯丙嗪可与曙红Y、赤藓红、乙基署红等卤代荧光素染料反应,形成离子缔合物,溶液颜色发生明显改变,可用光度法测定。

The first synthetic route uses 1,2,4-trimethoxybenzene and chloroacetonitrile in forming 2,4,5-trimethoxy-a-chlor-acetophenone under the anhydrous condition, then the intermediate condensates with papaverine forming the core pyrro[2,l-a]isoquinoline, followed by formation and lactonization to form the lactone ring. The second synthetic route uses prepared aldehyde with prepared ethyl nitroacetate by Knoevenagel condensation to obtain 2-Nitro-3-(2,4,5-tris-methoxy-phenyl)-acrylic acid ethyl ester and 2-Nitro-3-(2,4,5-tris-benzyloxy -phenyl)-acrylic acid ethyl ester etal intermediates. The lamellarin skeleton could arise from condensation of the papaverine and these intermediates by Michael reaction, the ester group is provided for subsequent lactonization. The third synthetic route uses coumarin or indan-l,3-dione derivatives and papaverine to form lamellarin under basic conditions.

第一条路线首先从1,2,4-三甲氧基苯出发与卤乙腈作用合成卤代芳酮中间体,然后与罂粟碱反应合成开链片螺素,最后经乙酰化、去保护、成内酯环得到片螺素;第二条路线由制备的芳醛和制备的硝基乙酸乙酯经缩合得到2-硝基-3-芳基丙烯酸乙酯,然后由该中间体与罂粟碱反应,在完成关环的同时也引入酯基,最后去保护、成内酯环得到片螺素;第三条路线是由香豆素或茚二酮出发,经溴代后的中间体与罂粟碱反应,得到片螺素的基本框架。

Here hot halogen has the characteristic very much, the common hot halogen is boils with the jar, after but here is the halogen is good again uses the bittern to recook fries, recommends you to choose the beef element to bundle the chicken, the halogen intestines, the pig ear matches the fragrant-flowered garlic "four to gather one"!

这里的热卤很有特色,一般的热卤是用罐子煮的,而这里是卤好之后再用卤水回锅炒,推荐你选择牛肉素捆鸡、卤肠子,猪耳朵搭配韭菜的&四合一&!

The main reasons were that the algae and organism in the water decreased the ability of removing pollutants by coagulations, the algae which grown again in the open sedimentation tank weakened the removal effect of algae by coagulation; because of the accumulation of algae and algae toxin in the filtration tank, the concentration of algae toxin in the effluent increased; by the function of fluid chlorine, the algae and organisms after the filtration will release microalgae toxin and produce a lot of byproduct such as microalgae toxin, sobomyl and so on, meanwhile, the chlorination produce considerable halide and halo-acetic acid and other disinfection byproduct.

主要表现在藻类和溶解性有机物的存在降低了混凝去除污染物的能力;藻类在露天平流沉淀池中再生长,抵消了混凝除藻效果;藻类和藻毒素在滤池中积累,导致滤后藻毒素升高;穿透滤池的藻类和有机物在液氯作用下,释放微囊藻毒素、土臭素和二甲基异冰片等胞内物质,同时生成数量可观的卤代烃和卤乙酸等消毒副产物。

DDT (dichlorodiphenyltrichloroethane):Synthetic insecticide belonging to the family of organic halogens.

滴滴涕:二氯二苯基三氯乙烷:一种合成的有机卤素化物杀虫剂。

DDT (dichlorodiphenyltrichloroethane):Syn the tic insecticide belonging to the family of organic halogens.

滴滴涕:二氯二苯基三氯乙烷:一种合成的有机卤素化物杀虫剂。

DDT (dichlorodiphenyltrichloroethane):Synthetic insecticide belong ing to the family of organic halogens.

滴滴涕:二氯二苯基三氯乙烷:一种合成的有机卤素化物杀虫剂。

Wherein X represents a hydrocarbon group or hiydrocylhy-drocarbon group having 1 to 14 carbon atoms, a represents an integer of 1 to 6,b represents an integer of 1 to 5,R's represent a hydrogen atom,a halogen atom,a hydrocarbon group having 1 to 8 carbon atoms or an aryl,group independently from each other,and n represents an average number which is 1 to 10 and4,4'dihydroxybiphenyl,and having a softening point of not higher than 120℃,and not lower than 60℃.

其中x是一个油气组或hiydrocylhy-油气群有1至14个碳原子, a代表整数1到6,B代表整数1到5,R的是氢原子,卤素原子,烃类组有1至8个碳原子或一个芳,77独立于对方,而n是一个平均这个数字是1至10条和第4,4'dihydroxybiphenyl,并有软化点不高于120℃,不得低于60℃。

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On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面,更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值,分为几个相等的区间作为横轴,并将各区间内所测定值依所出现的次数累积而成的面积,用柱子排起来的图形,也叫做柱状图。

You rap, you know we are not so good at rapping, huh?

你唱吧,你也知道我们并不那么擅长说唱,对吧?