卡介苗

The Bacillus Calmette-Guerin is an effective intravesical immunomodultor in preventing the recurrence and progression of the transitional cell carcinoma.

卡介苗作为一种有效的生物免疫修饰剂，在预防肿瘤进展及复发方面都取得了很好效果。

Based on relative literatures,this part has included five resesearch aspects as below.1 Fifteen compounds were isolated and purified by extraction,column chromatography,and their structures were determined on the basis of spectral analysis: acteoside(Ⅰ-1),isoacteoside(Ⅰ-2),crenatoside(Ⅰ-3),cistanoside F(Ⅰ-4),sinapoyl-4-O-β-D-glucoside(Ⅰ-5),adenosine(Ⅰ-6),β-siterol(Ⅰ-7),oleanic acid(Ⅰ-8), succinic acid(Ⅰ-9),caffeic acid(Ⅰ-10),protocatechuic aldehyde(Ⅰ-11),p-hydro xybenzyl alcohol(Ⅰ-12),β-daucosterol(Ⅰ-13),D-galacitol(Ⅰ-14),D-mannitol(Ⅰ-15).Ⅰ-4～15 were obtained from this plant for the first time,andⅠ-6,7,9,and 13 were isolated from Orobanche genus for the first time.2 The scavenging test of DPPH showed that most compounds have comparative antioxidant activity as L-ascorbic acid and part of them show better activity such as the O.coerulescens extract and phenylethanoid glycosides.Acteoside showed potent free radical scavenging effects with a median inhibition concentration of 25.6μg/ml.3 The anti-HBV activities of acteoside,isoacteoside and crenatoside were measured,and all of them showed suppressive activity on the expression of HBsAg and HBeAg in the HepG2.2.15 cell line.

本论文在文献调研基础上对紫花列当化学成分及生物活性进行了研究，并从免疫抗病毒角度探讨紫花列当中特征性成分类叶升麻苷的肝保护作用及其机制。1采用大孔树脂、硅胶和Sephadex LH-20等色谱技术对紫花列当进行系统的植物化学研究，从中分离得到19个化合物，利用UV和NMR等波谱手段及理化性质鉴定了其中的15个化合物，分别为类叶升麻苷(Ⅰ-1)、异类叶升麻苷(Ⅰ-2)、crenatoside(Ⅰ-3)、cistanoside F(Ⅰ-4)、sinapoyl-4-O-β-D-glucoside(Ⅰ-5)、腺苷(Ⅰ-6)、β-谷甾醇(Ⅰ-7)、齐墩果酸(Ⅰ-8)、琥珀酸(Ⅰ-9)、咖啡酸(Ⅰ-10)、原儿茶醛(Ⅰ-11)、对羟甲基苯甲酸(Ⅰ-12)、β-胡萝卜苷(Ⅰ-13)、D-半乳糖醇(Ⅰ-14)和甘露醇(Ⅰ-15除化合物Ⅰ-1、Ⅰ-2和Ⅰ-3外，其余化合物均为首次从该植物中分离得到。2)通过大孔树脂富集该药材有效部位苯乙醇总苷，并采用HPLC测得其所含特征性成分类叶升麻苷的含量可达80%以上。3DPPH自由基清除试验显示紫花列当提取物及其所含的苯乙醇苷类化合物均具有较好的抗氧化能力，其清除DPPH自由基能力接近于抗坏血酸。4采用卡介苗整体致敏、脂多糖离体攻击构建大鼠原代肝细胞免疫性损伤模型，在体外观察类叶升麻苷的保肝作用。

ObjectiveTo investigate the effect of scutellarin on immune hepatic injury induced by Calmette-Guerin bacillus vaccine and Lipopolysaccharide in mice.

目的观察灯盏乙素对卡介苗和脂多糖诱导的小鼠免疫性肝损伤的影响。

ABSTRACT:Nine proteins encoded by Mycobacterium tuberculosis RD1 region are important protective antigens that become absent in long passaging of Mycobacterium tuberculosis. They only exist in pathogenic Mycobacteria and are absent in Bacille Calmette-Guerin and environmental Mycobacteria. With good immunogenicities, they may play an important role in the diagnosis and prevention of Mycobacterium tuberculosis.

RD1区编码的9个蛋白，是结核分枝杆菌在长期传代过程中丢失的重要保护性抗原，仅存在于致病性分枝杆菌中，在卡介苗及环境分枝杆菌中缺失；其有较强的免疫原性，在结核病的诊断中发挥重要作用。

The new BCG immunisation programme now identifies and vaccinates babies and older people who are most likely to catch TB, especially in those living in areas with a high rate of TB or whose parents or grandparents were born in a country where TB is common.

新卡介苗免疫接种计划，现在确定和vaccinates婴儿和老年人的人谁最有可能赶上结核病，尤其是在那些生活在地区与高企的结核病或其父母或祖父母出生在该国结核病是共同的。

That the time to hit the designated hospitals in the BCG arm a needle bar, a bit like playing penicillin skin test to do the same.

到时候去那指定的医院在打卡介苗的那个胳膊上扎一针，有点象打青霉素做的皮试一样。

Methods: The ratios of Th1/Th2 cells in the mouse with immunological liver injure were detected by flow cytometry with two color intracellular cytokine staining; the changes in substance P, vasoactive intestinal peptide in the pituitary gland and peripheral blood were detemined by radio-immunoassary.

应用尾静脉注射卡介苗和脂多糖建立免疫性肝损伤小鼠模型，分离小鼠淋巴细胞，经佛波醇乙酯、离子霉素、莫能菌素刺激培养6h后，收获细胞，利用细胞内细胞因子染色流式细胞术检测Th1/Th2比例：采用放免法检测血浆和脑垂体中SP、VIP含量。

Effects and mechanisms of total glucosides of paeony on joint damage in rat collagen-induced arthritis.

白芍总苷对卡介苗加脂多糖引起的小鼠免疫性肝损伤的保护作用。

Tuberculin-negative people should be immunised with BCG.

结核菌素阴性的人应免疫卡介苗。

If we have to inoculation, then attention should be paid to the following points (1) has been suspected to have tuberculosis and suspected to have been infected with TB, and should be by the tuberculin test, tuberculosis infection has not been identified before BCG vaccination.

如果要再接种的话要注意以下几点（1）疑似已得结核病及疑似已被结核菌感染的人，应先经结核菌素测验，确定没有被结核菌感染，才可接种卡介苗。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。