卟啉

The maximum absorption peak was at long wavelength (＞650nm), extinction coefficient achieves 10〓 degree, which was one degree higher than HpD. The study has revealed that CPD photosensitizer appeared blue movement under the relevant body environment. The spectra parameters provided basis for selecting light source of PDT. Measurement system which measured singlet oxygen and its quantum yields within the infare range had been set up and the quantum yields of singlet oxygen for CPD were reported: the quantum yields of singlet oxygen for CPD〓 was the highest (φ=0.83) while he quantum yields of singlet oxygen for CPD〓 was the lowest (φ=0.83). Photobleaching's half life time was studied.

给出了此类光敏剂的光谱指认和光谱参数：其吸收光谱峰值位于长波红光区(＞650nm)，摩尔消光系数达10〓LmoL〓cm〓量级，比血卟啉衍生物高出一个数量级；研究揭示了此类光敏剂在近似体内环境下光吸收的蓝移现象，为光动力治疗光源的选择提供了依据；建立了在近红外光谱区中测定敏化单态氧的光谱和量子产率测量系统，报导了该类光敏剂敏化单态氧的量子产率，其中CPD〓的单态氧量子产率最高(φ＝0.83)，CPD〓的单态氧量子产率最低(φ＝0.51)；测定了二氢卟吩类光敏剂的光漂白半衰期。

It has better characterristis : an enhanced absorption in far red region, shorter remain time, smaller untoward effects and also.With the appropriate light,the use of chlirins for therapy will have belter achievement.

和卟啉类光敏剂相比较，二氢卟吩作为第二代光敏剂，存在以下优点：最大吸收红移，摩尔系数变强，治疗深度增加，用量小，存留时间短，毒副作用小。

The structure model of 5, 10, 15, 20-meso-tetraphenylporphyrin has been optimized by the first-principle calculation. The result shows that the angle between the benzenes and the porphine plane is 55°, and the rotation of the benzenes lead to a slight bending of the porphine plane.

利用第一性原理确定了四苯基卟啉分子的结构模型，结果表明分子中的苯环与卟吩骨架的夹角为55°，且笨环的自由旋转导致卟吩骨架略微偏离平面形状。

All synthetic methods of the μ-oxo-bismetallo- tetraphenylporphyrins are comprehensively discussed, involving the two-step method, the chromatographic column method, the one-step method, the auto-oxidation method and the one-pot method developed by our group.

重点介绍了μ-氧代四苯基双核金属卟啉的合成方法，即两步合成法、柱色谱分离法、一步合成法、自氧化法以及本课题组最新开发的一锅法。其中一步合成法和自氧化法由于具有适用范围广、收率高等优点，将成为μ-氧代四苯基双核金属卟啉的主要合成方法。

First, by using p-methoxybenzaldehyde , p-hydroxybenzaldehyde and pyrrole as raw materials, 5-(p-hydroxyphenyl)-10,15,20-tri(p-methoxyphyenyl)porpyrin was prepares under acidity condition and the let reacted with benzoyl chloride, o-nitrobenzoyl chloride, m- nitrobenzoyl chloride and p- nitrobenzoyl chloride respectively under alkalinity condition with DMF as solvent.

以对-甲氧基苯甲醛、对-羟基苯甲醛和吡咯为原料，在酸性条件下合成了5-对羟苯基10，15，20-三对甲氧苯基卟啉，再以该化合物为原料分别与苯甲酰氯、邻-硝基苯甲酰氯、间-硝基苯甲酰氯和对-硝基苯甲酰氯反应，在碱性条件下以DMF为溶剂合成了四种目前尚未见文献报道的对-甲氧基卟啉硝基苯甲酸酯类化合物。

Porphyrins and metalloporphyrins have good optical and thermal stability, their absorption spectra lie in visible area. And they have many physical and chemical characters, so they are widely used in biochemistry, medical chemistry, analytical chemistry, actinic catalysing and meterial chemistry.

卟啉及金属卟啉具有良好的光和热稳定性，其吸收光谱在可见光范围内，具有许多独特的物理、化学性质及其它功能性质，因而在生物化学、药物化学、分析化学、光化催化和材料科学等领域都得到广泛的关注和应用。

The conjugated macrocycle,which is built by 20 carbon atoms and 4 nitrogen atoms,prospers the whole nature and the chemical research field due to its particular property,so it has attracted more and more attention.

这种由20个碳原子和4个氮原子组成的共轭大环以其独特的魅力不光丰富了自然界也丰富了人类化学研究领域，越来越多的目光被卟啉化合物所发出的光彩所吸引，卟啉化合物也在大家的关注中得到迅速的发展和应用。

Wheares under buffer pH5.2, there is no strong static electricity and instead being a longer wavelength movement; SDS\'s participation just restricts the relative movement of heme\'s ethylene; a new fluorescent peak forms and the reduction of enzymatic activity is due to the packing of micella\'s formation.

强变性的阴离子表活剂SDS与带净正电荷和弱负电荷的SBP(处于pH2.6和4.2缓冲液中)有强烈的静电力作用，酶活力丧失，二级结构变化，荧光强度增加，特征Soret发生蓝移，卟啉环的π-π*共轭的分裂能增大；而当SBP带净负电荷(pH5.2)时，没有静电吸引力，Soret带发生红移；SDS的引入只是限制了血红素上乙烯取代基的运动，使其与卟啉环共轭：极性环境的变化导致产生新的荧光峰；酶活力因胶团包裹作用而有下降。

In our group, metalloporphyrins are found as useful phosphorescent probe to investigate biomolecules such as DNA, RNA, protein and so on. The splittings appearing in the excitation spectra indicate the characteristics of exitonic coupling.

近几年该课题组开展了以金属卟啉室温磷光作为探针的分析应用研究，已经发现在生物介质如DNA、RNA、蛋白质等介导下，卟啉室温磷光激发光谱发生分裂，表现出强烈的激子耦合特征。

The formal potentials in cyclic voltammograms of these 3+ valence complexes are followed: Co〓-TPPS (-0.08V )＞Fe〓TPPS (-0.14V)＞Mn〓-TPPS (-0.23V). The electrochemical reaction of Mn〓-TPPS is reversible, and both of Co〓-TPPS and Fe〓-TPPS are quasi-reversible. The standard heterogeneous rate constants of Co〓-TPPS and Fe〓-TPPS were determined to be 1. 4×10〓cm/s and 1.4×10〓cm/s respectively. The rates of electrode reaction are as followed: Mn〓-TPPS＞Co〓-TPPS＞Fe〓-TPPS, e.i. Mn〓-TPPS is the most easily oxidized by the dissolved oxygen, and Fe〓-TPPS is oxidized slower than Co〓-TPPS. Ni〓-TPPS can not be oxidized. It is considered that oxygen plays an important role in the valence change of central metal atom and the rate of electron transfer in some metalloporphyrins.

三价金属卟啉络合物在循环伏安图上可得到三价到二价的还原和氧化响应，电极电位从大到小排列为：Co〓-TPPS(-0.08V)＞Fe〓-TPPS(-0.14V)＞Mn〓-TPPS(-0.23V)，电极反应可逆性也不相同，Mn〓-TPPS是可逆过程，Co〓-TPPS、Fe〓-TPPS是准可逆过程，实验测得Co〓-TPPS的标准电极反应速率常数ks＝1.4×10〓cm/s，Fe〓-TPPS的ks＝1.4×10〓cm/s，电极反应的速率从大到小为：Mn〓-TPPS＞Co〓-TPPS＞Fe〓-TPPS，即Mn〓-TPPS最容易被溶解氧所氧化，Fe〓-TPPS被氧化的速度最慢，Ni〓-TMPyP不能被氧化，因此我们认为溶解氧对金属卟啉中心离子的价态和电子转移速率起着重要作用。

In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是，在否定句或疑问句里，这种带有"do"的方法表达的效果却没有什么强调的意思。

Go down on one's knees;kneel down

屈膝跪下。。。下跪祈祷