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Objective: To evaluate the therapeutic effects and mechanism of Huayulifei on blemycin-induced pulmonary interstitial fibrosis in rats.

目的:探讨化瘀理肺方对博莱霉素致大鼠肺间质纤维化的治疗作用及机制。

Results:In the BRE group,the MAD was significantly lower and the SOD significantly highter than which of BLM group,and the degree of fibrosis was more mitigative than BLM group when examined by microscope,similar to that in the DXM group.

结果:灯盏花素注射液组与地塞米松注射液组结果相似,与博莱霉素组相比,肺组织SOD升高,MDA下降,光镜和电镜结果提示肺纤维化程度减轻。

Abstract] Objective To study the effect of zinc protoporphyrin,an inhibitor of heme oxygenase-1(HO-1),on pathological and pathophysiologic changes of rat pulmonary fibrosis induced by bleomycin,and to investigate the role of Znpp in the pathogenesis of pulmonary fibrosis.

目的 观察血红素加氧酶-1(HO-1)抑制剂锌原卟啉对博莱霉素致大鼠肺纤维化模型病理和病理生理改变的影响,探讨Znpp在BLM诱导肺纤维化发病中的作用。

The method contrasts group in physiological saline of the infuse inside tracheal spile, element of mildew of Lai of rich of infuse of the others bandicoot builds lobar fiber to turn a model.

方法对照组在气管插管内注入生理盐水,其余大鼠注入博莱霉素建立肺纤维化模型。

Results The degree of alveolitis and pulmonary fibrosis in group A was improved compared with that in group M.

博莱霉素致大鼠肺纤维化的进程中,2-6周内BALF中的TIMP-1的浓度逐渐升高(P<0.01)。

Methods: 60 SD rats were divided into 4 groups randomly, the nomal group, the model group, QZHJ group, and the hydrocortisone group. Rats were sacrificed in bdtch on the 3rd, 7th and 21st day after treatment, then the concentration of interleukin-8(IL-8) in bronchoalveolar lavage fluid and the content of transforming growth factor-β1 (TGF-β1) of lung tissue were deected, while the severity of alveolitis and fibrosis were measured.

将60只健康SD大鼠随机分为正常组、模型组、芪术合剂组和强的松组,经气管滴入博莱霉素复制肺纤维化大鼠模型,并分组予以治疗,于治疗后第3、7、21日分批处死大鼠,每组每次6只;用免疫组化法观察肺组织转化生长因子-β1的表达,并测定支气管肺泡灌洗液中中性粒细胞和白介素-8的水平。

Objective: To study the role of exogenic dmPGE2 in progresse of pulmonary fibrosis in rats. Methods: 63 Wistar rats were divided into three groups: the normal control group, the model group treated with bleomycin and the dmPGE2 group which were given dmPGE2 lnmol.

目的:探讨16,16二甲基前列腺素E2 (dmPGE2)在博莱霉素诱导大鼠肺纤维化进程中对结缔组织生长因子表达水准的影响。

In the model group and the treatment group, pulmonary fibrosis was reproduced by the intratracheal injection of bleomycin.

博莱霉素气管内滴入建立大鼠肺纤维化模型,正常对照组气管内滴入生理盐水。

Objective To study the differences of bleomycin-induced pulmonary fibrosis in mice induced by intravenous injection and intratracheal instillation of bleomycin.

目的 探讨静脉注射和气管内滴入博莱霉素对小鼠肺纤维化形成的差异。

Methods All of rats were randomly divided into seven groups and were intratracheally infused with bleomycin to build the model.

大鼠麻醉后,经气管软骨环间隙向心端穿刺,气管内注入博莱霉素A5(5 mg/kg)建立大鼠肺纤维化模型,假手术组大鼠在同样麻醉条件下气管内注入等量生理盐水。

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