单纯疱疹

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Thus, in polyarthritic rat, a model of chronic inflammatory pain, we demonstrated that herpes simplex irus ector mediated oerexpression of proenkephalin A in primary sensory neurons at the lumbar leel elicited both antihyperalgesic and anti-inflammatory actiities.

在一个慢性炎症性疼痛模型－多关节炎鼠上，我们证明单纯疱疹病毒媒介介导的前脑啡肽在腰水平初级神经原的过度表达引起了抗痛觉高敏和抗炎症活动。

OBJECTIE To ealuate the effect of herbal eye drop of Reduqing and potentialization of ultrasonic nebulous adiministration of Reduqing on experimental herpes simplex keratitis in rabbits, the acute toxicity test and the irritating eye reaction.

目的 评估中药热毒清滴眼液对兔实验性单纯疱疹性角膜炎(herpessimplexkeratitis ，HSK)作用和超声雾化强化给药的疗效及急性毒性与眼的刺激反应。

HSV-1 often induce latent and recrudescent infection in mucosa epithelium and nervous system, the infection rate...

单纯疱疹病毒Ⅰ型(HSV-1)常引起粘膜上皮及神经系统潜伏和复发感染，其人群感染率高达50％-90％。

HSV-1 often induce latent and recrudescent infection in mucosa epithelium and nervous system, the infection rate is up to 50％-90％.

单纯疱疹病毒Ⅰ型(HSV-1)常引起粘膜上皮及神经系统潜伏和复发感染，其人群感染率高达50％-90％。

The metabolic thermogenic power data of the HSV-2 infected HeLa cells and the FMDV infected BHK-21 cells were determined by LKB-2277 bioactivity monitor. The aim of the study was to investigate the difference of the cell metabolism under the action of two different viruses and the effects of hyperthermia and drugs on it.

本论文采用LKB－2277生物活性检测器研究HeLa细胞在单纯疱疹Ⅱ型病毒感染和BHK－21细胞在口蹄疫病毒感染下的能量代谢过程，以及热疗及抗病毒药物干扰素对这一过程的能量代谢的影响。

HSV's design team, led by Julian Quincey, have also left a distinctive mark on the final product.

单纯疱疹病毒的设计团队，由朱利安坎塞领导，也留下了最终产品的独特标记。

The Herpes simplex virus, for example, infects 80% of adults.

例如会感染80 ％的成年人的单纯疱疹病毒。

The results indicated that the glass slide modified with agrose has the strongest ability to combine Protein. 2. Protein microarray in TORCH infection diagnosis Protein microarrays for detection of TORCH antibodies in human sera were fabricated by printing monoclonal antibodies on agarose film coated glass slide. The sporing concentration, specificity and cross-reactivity were investigated.

蛋白质芯片在TORCH检测中的应用研究 TORCH是指发生在孕期的各种微生物感染所致的一类临床综合症，包括弓形体(Toxoplasmagondii，Tox)、风疹病毒(Rubellavirus，RV)、巨细胞病毒(Cytomegalovirus，CMV)、单纯疱疹病毒(Herpessimples Virus，HSV)及其他感染（Others，包括微小病毒属、人免疫缺陷病毒、肝炎病毒、梅毒等）。

Objective: To explain the effect of HSV-TK and B7 combined injection on tumor size, animal survival time and cell immunogenicity.

目的：探讨逆转录病毒介导的单纯疱疹病毒胸苷激酶基因和共同刺激因子B7基因联合使用对乳腺癌动物模型的体内治疗作用。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。