单纯疱疹

ABSTRACT Herpes simplex virus type 1 (HSV-1), which infects eyes resulting in herpes simplex keratitis, is generally considered to be the most common cause of blindness both at home and abroad at present. High rate of recurrence is the chief reason.

单纯疱疹病毒1型（Herpes simplex virus type 1，HSV-1）感染眼部所导致的单纯疱疹性角膜炎(Herpes simplex keratitis，HSK)以其高复发率、高致盲率严重损害患者视力，是目前国内外公认的最常见的致盲眼病之一。

We reviewed all skin lesions in all HIV patients diagnosed in our department between 1990 and 1998 to document the spectrum of skin manifestations, the frequency of each disorder, and their relationship with CD4 counts. A total of 64 HIV patients were studied, including 38 with acquired immunodeficiency syndrome CD4 200 x 10(6 cells/L and 26 who had not developed AIDS. There were 142 episodes of skin conditions representing 25 different skin diseases, including oral candidiasis (15% in non-AIDS vs 71% in AIDS patients), drug eruptions, herpes simplex, seborrheic dermatitis, dermatophytosis, herpes zoster, secondary syphilis, condyloma acuminatum, Kaposi's sarcoma (16% among AIDS patients), hairy leukoplakia, and molluscum contagiosum (13% among AIDS patients), in decreasing order.

我们回顾自 1990 年到 1998 年人类免疫不全病毒感染患者在本院皮肤科的诊断，归纳整理各种皮肤疾病发生的机率及与 CD4 数值间的关系。64 位人类免疫不全病毒感染患者，包括 38 位爱滋病患者（CD4 200 x 10(6) cells／L）及 26 位非爱滋病患者，共有 142 种皮肤症状，分属於 25 种不同种类的皮肤疾病，依发生率的高低，包括口腔的白色念珠菌感染（非爱滋病患者：15%；爱滋病患者：71%）、药物疹、单纯疹、脂漏性皮肤炎、皮癣菌感染、带状疱疹、二期梅毒、尖圭湿疣、卡波西氏肉瘤(爱滋病患者：16%)、毛状黏膜白斑、传染性软疣(爱滋病患者：13%)；并针对较特殊的病例做一介绍，如疣状的单纯疱疹病毒感染、临床表现像尖圭湿疣的传染性软疣感染及与爱滋病相关的色素性红皮症。

Of an oral circumstance, a cold sore, or, otherwise known as a fever blister, is classified within herpes, as herpes simplex virus types one and two.

口头情况下，感冒疮，或以其他方式被称为热水泡，被归类在单纯疱疹病毒，单纯疱疹病毒作为第一类和第二类。

Halford joined SIU's faculty in 2007, but has been researching the herpes simplex virus since 1992, first focusing on HSV-1, which causes cold sores and sometimes leads to genital herpes.

哈尔福德于2007年加入萧的教师，但自1992年以来一直在研究单纯疱疹病毒，首先侧重于单纯疱疹病毒1，这会导致唇疱疹，有时会导致生殖器疱疹。

Methods: Mice were inoculated intracerebrally with herpes simplex virus type1(HSV-1) to form herpes simplex encephalitis. MMP-9 gelatinolytic activity was assessedby zymography from brain tissues 3 days and 7 days after HSV-1 infected.

第一部分单纯疱疹病毒性脑炎相关病理机制的研究实验一MMP-9在单纯疱疹病毒性脑炎中的表达及对血脑屏障的影响目的：研究单纯疱疹病毒感染小鼠脑组织后MMP-9的变化及对血脑屏障通透性的影响。

PARTⅡCharacteristic of MMP-9 Activation in Microglia and itsCytokines Secretion after HSV-1 infectedObjective: To investigate the characteristic of MMP-9 activation in microglia and itscytokines secretion.Methods: Balb/c mice were injected intracerebrally with herpes simplex virus type 1(HSV-1) to form herpes simplex encephalitis.

第二部分HSV-1感染小胶质细胞后MMP-9及炎性因子分泌特点研究目的：研究单纯疱疹病毒(HSV-1)感染小胶质细胞系BV2后炎性因子的表达特点，探讨BV2细胞可否作为小鼠单纯疱疹病毒性脑炎模型的替代研究对象。

Like other alpha herpesvirus such as herpes simplex virus type I, varicella-zoster virus and bovine herpesvirus type I, PRV also has some typical characteristics of alpha herpesvirus, including latency and neurotropism.

与同属α—疱疹病毒亚科的人单纯疱疹病毒、水痘-带状疱疹病毒和牛疱疹病毒Ⅰ型等一样，PRV具有潜伏感染和神经嗜性等α—疱疹病毒的典型特征。

Methods Using the well-conserved regions of the DNA polymerase gene in human herpesviruses,we synthesized two pairs of primer,including one pair of primer designed to amplify herpes simplex virus type 1 and 2,Epstein-Barr virus and cytomegalovirus,another pair of primer to varicella-zoster virus and human herpesvirus 6 by PCR.

2 0 0 2年 1～ 12月浙江大学儿童医院在疱疹类病毒高度同源序列DNA多聚酶基因中设计两对通用引物，该引物能同时扩增单纯疱疹病毒Ⅰ型与Ⅱ型、爱泼斯坦—马尔病毒、人巨细胞病毒、水痘带状疱疹病毒和人类疱疹病毒 6型(HHV6) 6种病毒。

The successful cloning of fulllength gG2 of HSV2 and a successful forecast to B cell epitope of gG2 provide evidences and references for developing diagnostic kits for herpes virus infection and finding better target sites of HSV2 vaccine.

成功构建单纯疱疹病毒2型（HSV2）gG2全长基因克隆，为单纯疱疹病毒感染的诊断试剂的研发及抗单纯疱疹病毒疫苗研究寻找更好的靶位点提供研究材料和参考。

The successful cloning of fulllength gG2 of HSV2 and a successful forecast to B cell epitope of gG2 provide evidences and references for developing diagnostic kits for herpes virus infection and finding target sites of HSV2 vaccine.

成功构建单纯疱疹病毒2型（HSV2）gG2全长基因克隆，为单纯疱疹病毒感染的诊断试剂的研发及抗单纯疱疹病毒疫苗寻找更好的靶位点提供研究材料和。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。