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DATA SYNTHESIS: Il-17 exerted the biological function after combines with its receptor maybe induced the occurrence and the development of the osteoarthritis by the way of increasing the chondrocyte, expression of inducible nitricoxide synthase and nitrogen monoxide, boosting up the tbe chondrocyte and the expression of MMP-1/3/13, boosting up the activation of the aggrecanase and the collagenase, boosting the decompose of the cartilage proteoglycan and collagen, boosting up the monocyte evocable breakage of the cartilaginous matrix.

资料综合:白细胞介素17通过与其受体结合发挥生物学作用,其可能通过增加关节软骨细胞诱导性一氧化氮合酶表达和一氧化氮产量,增强软骨细胞基质金属蛋白酶(MMP-1/3/13)的表达,增强蛋白聚糖酶和胶原酶活性,促进软骨蛋白多糖及胶原降解,并增强单核细胞对软骨基质的破坏,从而诱导和加速骨关节炎的发生和发展。

In contrast, nasal administration of a mixture of MBP6886 and 8799 completely blocked gpMBPinduced EAE even at lower dosage than being used alone. Rats tolerized with MBP6886+8799 nasally showed decreased T cell responses to MBP, reflected by lymphocyte proliferation and IFNγ ELISPOT assays.

淋巴细胞增殖实验和IFNγ ELISPOT检测显示,与鼻黏膜给予大鼠MBP110128组相比,鼻黏膜给予大鼠MBP6886+8799可降低T细胞对于MBP的反应性,淋巴结单核细胞中表达IFNγ和TNFα mRNA的细胞数减少,而两组表达TGFβ及IL4 mRNA的淋巴细胞数都低。

Objective To study the effect of monocyte chemotactic protein-1(MCP-1) on the proliferaion of tumor infiltrating lymphocytes in patients with transitional cell cancer of bladder and their cytoxicity to bladder tumor.

目的 探讨不同浓度的单核细胞趋化因子(MCP 1)对肿瘤浸润淋巴细胞增殖的作用,以及能否增加TIL对膀胱肿瘤细胞的细胞毒性。

The acute toxicity andmain organs of pathological section for 30 days were observed. Result 1. Ganoderma lucidum spores oil at 0.20g/kg, 0.40g/kg, 1.20g/kg dose couldsignificantly promote the lymphocyte transformation, raise clearance index numberand phagocytic index number, enhance the activity of NK cells and the level of TNF-α, IL-2 in spleen. Ganoderma lucidum spores oil at high dose and middle dose couldsignificantly enhance the serum erythrocytolysin level.

实验结果 1低、中、高灵芝孢子油组(0.20g/kg,0.40g/kg,1.20g/kg)均可提高小鼠单核-巨噬细胞的吞噬指数及碳廓清指数,促进ConA诱发脾淋巴细胞转化,增强小鼠NK细胞活性,提高脾细胞产生TNF-α和IL-2的能力;高、中剂量灵芝孢子油可提高小鼠的血清溶血素水平。

In one type of AML, called acute monocytic leukemia, the leukemia cells are more likely to invade the lining of the spinal canal or brain.

与急性髓细胞白血病的其他亚型相比,急性单核细胞白血病患者的肿瘤细胞更容易侵入椎管或脑内。

This is usually a physical response to infection or inflammation because monocytes or tissue macrophages are activated by various stimuli to liberate various cytokines with pyrogenic activity.

这往往是由于人体对感染及炎症的生理性反应,在其中,单核细胞或组织巨噬细胞被繁多的刺激物激活而释放多种致热性细胞活素。

There were significant differences between all the experimental groups and the control group (F=193.25, P<0.01). Conclusions IL-1β and TNF-α induce a strong expression of MCP-1 mRNA and protein in HUVECs. Both cytokines may be involved in the atherogenesis by inducing the liberation of MCP-1 by endothelial cells and increasing the recruitment of monocytes into the subendothelial space.

IL-1β和TNFα均能显著增强内皮细胞MCP-1 mRNA和蛋白的表达,提示它们通过诱导内皮细胞产生MCP-1,吸引单核细胞迁入动脉内膜而参与动脉粥样硬化的发生和发展。

These findings indicate that the novel prepared triphasic ceramic composites support adhesion, proliferation and osteogenic differentiation of hMSC as well as osteoclastogenesis of human monocytes in co-culture with osteoblasts.

结果提示制备的三相陶瓷复合材料支持人骨髓间充质干细胞的黏附、增殖和成骨分化,以及人单核细胞与成骨细胞联合培养条件下破骨细胞形成。

Methods: K3 EDTA peripheral blood of 40 healthy volunteers was dealt with a self-made lysing solution and a FACS Lysing solution, and then the lysing effect on red blood cells and the influence on CD14(superscript +), CD45(superscript +) on lymphocytes, monocytes and granulocytes were detected.

应用流式细胞术对40份K3 EDTA抗凝外周血分别用自制流式细胞仪专用溶血素与FACS溶血素处理后,检测其对血液红细胞的溶解效果及对淋巴细胞、单核细胞和粒细胞表面特异性抗原CD14、CD45表达率的影响。

Methods: K3 EDTA peripheral blood of 40 healthy volunteers was dealt with a selfmade lysing solution and a FACS Lysing solution, and then the lysing effect on red blood cells and the influence on CD14+, CD45+ on lymphocytes, monocytes and granulocytes were detected.

应用流式细胞术对40份K3 EDTA抗凝外周血分别用自制流式细胞仪专用溶血素与FACS溶血素处理后,检测其对血液红细胞的溶解效果及对淋巴细胞、单核细胞和粒细胞表面特异性抗原CD14+、CD45+表达率的影响。

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