单核细胞的

And Spatholobus suberectus Dunn. provided protection activities against decapsulted KP-induced ER stress in U937 monocytes、B lymphoblast CA46 cells and PBMC of normal individuals. We also found a significantly increase of IL-1β、IL-6 and TNF-α proinflammatory cytokine by PBMC obtained from normal individual under decapsulated KP treatment.

我们筛选超过60种中药及生物活性成分中，并且发现小蘗碱、牛磺酸、鸡血藤萃取物和穿心莲萃取物能够保护去荚膜克雷伯氏肺炎杆菌诱发U937单核球细胞、CA46 B淋巴球细胞和健康者身上周边血液单核球细胞的内质网压力。

AIM: To investigate the relationship among MCP-1 and monocyte chemoattract protein activity and pathogenesis of lung cancer.

目的：探讨单核细胞趋化蛋白-1（MCP-1）含量及其活性-单核细胞趋化活性变化与肺癌发病的关系。

Methods Monocytes in peripheral blood were obtained from 12 patients with acute myocardial infarction, 16 unstable angina pectoris, 12 stable angina pectoris and 8 normals by ficoll density gradient centrifugalization. The cells were incubated for 48 hours to induce them to differentiate into macrophages by adding phorbolester 12-myristate 13-acetate. The levels of MMP-9 and TF in the supernatant were measured by ELISA.

密度梯度离心法提取12名急性心肌梗死、16名不稳定心绞痛、12名稳定型心绞痛患者和8名冠脉正常者的单核细胞，用佛波酯诱导其分化为巨噬细胞，ELISA法测定单核源巨噬细胞上清液MMP-9、TF含量。

Methods: The multinucleated osteoclasts were derived by 1,25-dihydroxyvitamin D3 and dexamethasone from bone marrow cells in the coculture system with primary osteoblastic cells.

采用原代培养的成骨细胞和骨髓单核细胞联合培养的方法，在1.25-2维生素D3和地塞米松作用下，使骨髓单核细胞分化形成破骨细胞。

Results The level of antibodies against monocytes (34.94%) were higher than that of the antibodies against lymphocytes (26.67%) in pretransplant patients. The level of antibodies in first time transplant patients (32.5%) was lower than that of antibodies in retransplant patients (59.7%). The patients with intensity of antibodies against monocytes PRA more than ≥50%only accounted for 1.87%, 10%MPRA50%for 17.62%and MPRA10%15.44%,respectively.Conclusion Before renal transplantation, the detection of MPRA level could predict the occurrence of rejection in renal transplantation.

结果 肾移植术前患者的抗单核细胞抗体水平较抗淋巴细胞抗体水平高，其百分比分别为34.94%和26.67%；而从患者初次和再次肾移植前的比较中可见，初次比再次产生的抗单核细胞抗体水平要低，其百分比分别为32.05%和59.7%；对于抗单核细胞抗体群体反应性抗体的强度，MPRA≥50%的只占1.87%，而50%10%以及MPRA结论在肾移植术前检测患者MPRA水平，对肾移植后的排斥反应能起到预测目的。

However, fully consideration of special structure and physiological function of CRP is critical to investigate whether CRP provide protect effect or pathogenic effect in the progression of atherosclerosis. CRP is a member of pentrxins family, which consists of five identical, noncovalently associated 23-kDa protomers arranged symmetrically around a central pore with a 102 A external diameter. Each protomer has a recognition face with a phosphocholine binding site consisting of two coordinated calcium ions adjacent to a hydrophobic pocket. The opposite face of the pentamer is the effector face, where complement Clq binds and Fc receptors are presumed to bind. A cleft extends from the center of the protomer to the central pore of the pentamer. Both faces ofpentamer form a special bi-phase structure: one face is the ligand recognition phase, which can recognize apoptosis cells and enzyme modified low density lipoprotein in which PCh is exposed.

CRP是一种五聚体蛋白，外径为102 A，由5个相同的单体以非共价键结合，形成双面的环形结构，每个单体的配体识别位点或受体结合位点分别位于五聚体两个平面上，分别组成配体识别相和效应器相，从而构成特殊的二相性结构：一面为配体识别相，含有磷酸胆碱(phosphorycholine，PCh)结合位点，能够使CRP识别在病理条件下暴露出PCh的凋亡细胞、酶修饰低密度脂蛋白(enzyme modified low density lipoprotein，E-LDL)等。E-LDL是天然低密度脂蛋白(native Low density lipoprotein，N-LDL)在多种蛋白酶，如胰蛋白酶、神经氨酸酶、胆固醇酯酶等作用下的代谢产物，其主要特点是结构发生改变(N-LDL大小均匀，平均直径250±30 A，E-LDL大小差异极大，直径为100-2000 A)，暴露磷酸胆碱位点，能够被CRP识别；另一面为效应器相，能够与巨噬细胞、单核细胞表面受体FcγRⅡa结合，介导巨噬细胞、单核细胞识别及吞噬凋亡、坏死细胞作用。

The model of ECV-304 cell oxidative stress injury was established by hydrogen peroxide (H2O2).Then EPZ-contained blood serum was taken as experimental drug. The adherence of monocytes to endothelial cell were measured by method of rose Bengal. The total RNA of cells was extracted. The intercellular adhesion molecule-1 (ICAM-1),vascular cell adhesion molecule-1 (VCAM-1) and MCP-1 mRNA expression in cells were detected by RT-PCR.MCP-1 protein expression were detected by ELISA.

采用过氧化氢建立离体培养的血管内皮细胞(ECV-304)氧化应激损伤模型，取健康大鼠每日灌服不同剂量的鲜姜有效部位(200，400，800 mg·kg-1)或阳性对照药洛伐他汀(40 mg·kg-1)，取含药血清作为受试药物，用孟加拉玫红染色法测定单核细胞与内皮细胞的黏附力；逆转录聚合酶链反应测定细胞内细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子(VCAM-1)以及单核细胞趋化蛋白(MCP-1)的mRNA表达水平；酶联免疫吸附法测定MCP-1蛋白表达水平。

Morphology, and nucleus phase showed that arthrospores are larger than basidiospores in diameter, basidiospores are mononuclear cells, the majority of arthrospores are dikaryocytes and the mononuclear cells are in minority, myceIia are dikaryocytes with typical clamp connection.

显微形态及核相观察表明：节孢子直径略大于担孢子，担孢子为单核细胞，节孢子绝大多数为单核细胞，少数为双核细胞，菌丝体为双核细胞并具有典型的锁状联合结构。

Morphology and nucleus phase showed that arthrospores are larger than basidiospores in diameter, basidiospores are mononuclear cells, the majority of arthrospores are dikaryocytes and the mononuclear cells are in minority, mycelia are dikaryocytes with typical clamp connection.

显微形态及核相观察表明：节孢子直径略大于担孢子，担孢子为单核细胞，节孢子绝大多数为单核细胞，少数为双核细胞，菌丝体为双核细胞并具有典型的锁状联合结构。

Therefore, we studied the presence of HCV RNA in monocytes and monocyte-derived DCs from chronic HCV patients.

因此，我们研究了慢性丙型肝炎患者单核细胞和单核细胞衍生DCs细胞中丙型肝炎病毒核糖核酸的表达。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新